NFL Week 7 Predictions: Best Picks Against the Spread

Payton Matthews | Updated Oct 15, 2019

San Francisco 49ers quarterback Jimmy Garoppolo

There are still two teams without a loss in the NFL: New England and San Francisco. Both are big favourites to stay undefeated this week.

Here’s a quick look at all the Week 7 matchups with Sports Interaction NFL odds. Games Sunday unless noted. Cleveland, Pittsburgh, Tampa Bay and Carolina are on the bye.

NFL Week 7 Point Spreads

Kansas City Chiefs at Denver Broncos, Thursday

Chiefs star quarterback and reigning NFL MVP Patrick Mahomes made his first professional start in Denver at the end of his 2017 rookie season. He won that one and both against the Broncos last year as well, although all three were close. Denver has won back-to-back games while Kansas City hast lost two in a row.

Point spread: Chiefs -3.5

Pick ATS: Denver

Los Angeles Rams at Atlanta Falcons

Next head coach fired in the NFL? Might well be Atlanta’s Dan Quinn with his team at 1-5 and on a four-game losing streak. The team is on the bye in Week 9 and rumours are it will happen then barring an immediate turnaround. The Rams were without star tailback Todd Gurley due to injury on Sunday and held to just 157 yards in a home loss to the 49ers.

Point spread: Rams -3

Pick ATS: Atlanta

Miami Dolphins at Buffalo Bills

In the Toilet Bowl game of the season, the Dolphins were 17-16 home losers to fellow previously winless Washington on Sunday after a missed 2-point try in the final seconds. QB Josh Rosen was benched but apparently will remain the starter. First meeting this year of AFC East rivals, with Buffalo coming off a bye week. The Bills don’t score much, but their defence has been fantastic in a 4-1 start.

Point spread: Bills -16.5

Pick ATS: Miami

Jacksonville Jaguars at Cincinnati Bengals

Jacksonville was a 13-6 loser at home to New Orleans on Sunday as rookie QB Gardner Minshew had his worst outing with 163 yards passing and a pick. Cincinnati is a winless train wreck under first-year coach Zac Taylor and lost 23-17 in Baltimore. The Bengals didn’t score an offensive touchdown over the first three quarters in a third straight game.

Point spread: Jaguars -3

Pick ATS: Cincinnati

Minnesota Vikings at Detroit Lions

Short week for Detroit as it visited Green Bay on Monday. The Vikings won their second in a row Sunday, 38-20 over the Eagles. Kirk Cousins threw four touchdown passes, three of them to Stefon Diggs. That should quiet Diggs’ reported traded demands because he wasn’t seeing the ball enough.

Point spread: Pick’em

Pick ATS: Detroit

Green Bay Packers Aaron Jones

Oakland Raiders at Green Bay Packers

The Raiders come off their bye week and have been a pleasant surprise at 3-2. Green Bay on a short week as it hosted Detroit on Monday. The clubs played a preseason game in Winnipeg back on Aug. 22 but field conditions were a disaster so both coaches held all their key players out.

Point spread: Packers -6.5

Pick ATS: Green Bay

Houston Texans at Indianapolis Colts

First meeting between AFC South rivals since Indianapolis went to Houston in the Wild-Card round of last season’s playoffs and won 21-7. That would be the last NFL win for now-retired Colts QB Andrew Luck. Indy comes off the bye week here, while Houston was an upset winner in Kansas City.

Point spread: Colts -1

Pick ATS: Indianapolis

Arizona Cardinals at New York Giants

The first two quarterbacks taken in the 2019 draft face off in Arizona’s Kyler Murray (No. 1 overall pick) and New York’s Daniel Jones (No. 6). The Giants were without their top three offensive players last Thursday in a loss at New England in running back Saquon Barkley, tight end Evan Engram and receiver Sterling Shepard. Decent chance Barkley and Engram return this week.

Point spread: Giants -3

Pick ATS: New York

San Francisco 49ers at Washington Redskins

The 49ers remained the NFC’s only unbeaten team with a 20-7 win at the Rams on Sunday. That San Francisco defence is so much better than it was last year. The Rams had only 157 yards. Washington fired Coach Jay Gruden last Monday and then got its first win Sunday in Miami, 17-16. Interim coach Bill Callahan switched back to Case Keenum at quarterback and he threw two TD passes to rookie Terry McLaurin.

Point spread: 49ers -10

Pick ATS: Washington

Los Angeles Chargers at Tennessee Titans

The Marcus Mariota Era with the Titans might be over as the former Heisman winner was benched for Ryan Tannehill in Sunday’s 16-0 loss in Denver. Most believe that Tannehill will start this week. The Chargers might be the NFL’s most disappointing team at 2-4 following a 24-17 home loss to the Steelers on Sunday. The Bolts didn’t score until the fourth quarter and rushed for a grand total of 32 yards.

Point spread: Titans -2.5

Pick ATS: Los Angeles

New Orleans Saints at Chicago Bears

Chicago is off its bye and expecting to get back starting QB Mitchell Trubisky after he missed a Week 5 loss to Oakland with a shoulder injury. The Saints remained unbeaten behind backup QB Teddy Bridgewater in a 13-6 win in Jacksonville on Sunday. Hey, the pope tweeted about the Saints on Sunday morning (accidentally we think) so they couldn’t possibly lose.

Point spread: Bears -3

Pick ATS: Chicago

Baltimore Ravens at Seattle Seahawks

Matchup of division leaders. Baltimore was a 23-17 home winner over Seattle on Sunday behind 236 yards passing and 152 yards rushing (and a TD) from quarterback Lamar Jackson. He became the first quarterback in the Super Bowl era to pass for at least 200 yards and rush for 150 in a single game. Seattle was a 32-28 winner in Cleveland behind another strong game from Russell Wilson, who still hasn’t thrown a pick yet.

Point spread: Seahawks -3.5

Pick ATS: Seattle

Philadelphia Eagles at Dallas Cowboys

Sunday night matchup and key game in the NFC East, which these teams have combined to win the past three years. Dallas swept the Eagles in two close games in 2018 on the way to the division crown. The heat is on Cowboys coach Jason Garrett in a three-game skid. Philly’s two-game winning streak ended in Sunday’s 38-20 loss in Minnesota.

Point spread: Cowboys -3

Pick ATS: Dallas

New England Patriots at New York Jets, Monday

Yet another patsy for the unbeaten Patriots, who have played arguably the NFL’s easiest schedule thus far. That includes a 30-14 home win over the Jets in Week 3 when New York set back offensive football years by totaling 105 yards and going 0-for-12 on third down. Both the Jets’ TDs were on defence. Third-string QB Luke Falk was the starter that day but has since been cut, and No. 1 Sam Darnold is back now. He returned from mono Sunday and was very good in an upset of Dallas.

Point spread: Patriots -10

Pick ATS: New York

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