NFL Week 5 Odds and Predictions: Best Picks Against the Spread

Payton Matthews | Updated Oct 05, 2020


Here’s a quick look at all the Week 5 matchups with Sports Interaction’s NFL odds. Green Bay and Detroit are on the bye.

We spoke a bit too soon in the Week 4 version of this story as the first coronavirus outbreak did hit the NFL and specifically the Tennessee Titans. Thankfully, the league and Titans seem to have things under control at this point, and it’s full steam ahead (we hope). Click here to bet on all Week 4 NFL games. 

Tampa Bay Bucs at Chicago Bears, Thursday

Tom Brady played in prime time games all the time with the Patriots but this will be his first with Tampa Bay. Brady amazingly has never lost a short-week Thursday game, going 10-0 (8-2 ATS). He did lose talented tight end OJ Howard to a season-ending injury in Sunday’s big comeback win over the Chargers. Chicago’s offence did nothing in Nick Foles’ first start under centre as the Bears were beaten 19-11 at home by Indianapolis to suffer their first loss.

Point spread: Bucs -5.5

Pick ATS: Chicago

Carolina Panthers at Atlanta Falcons

Short week for Atlanta as it visited Green Bay on Monday. Matt Ryan’s top two wideouts, Julio Jones and Calvin Ridley (who is having a monster season), were both going to play despite being listed as questionable due to injuries. Carolina is a surprising 2-2 after a 31-21 home upset of Arizona on Sunday again without superstar running back Christian McCaffrey, and he won’t be back for Week 5, either. Atlanta routed Carolina in both meetings last year.

Point spread: Falcons -3.5 (may change after Monday’s game)

Pick ATS: Atlanta (-2.5 alternate line)

Buffalo Bills at Tennessee Titans

The 3-0 Titans are unwanted extra rest as around 20 combined players and staffers tested positive for COVID-19 last week so the team couldn’t even enter its facility, much less play its scheduled game vs. Pittsburgh. Thus, it was a forced bye week. Needless to say, this game is dependent on things not getting worse on the Titans. On Monday, there were no positive tests on the team, so that’s promising. The Bills are 4-0 following an impressive win Sunday at Las Vegas.

Point spread: TBA


Las Vegas Raiders at Kansas City Chiefs

Kansas City was home to New England on Monday night, a game moved from Sunday because of some COVID-19 issues. The Raiders suffered their second straight loss Sunday and first in their new home of Las Vegas, 30-23 to Buffalo. The Silver & Black were without good-looking rookie receivers Henry Ruggs and Bryan Edwards due to injury. Kansas City had no trouble in sweeping the Raiders yet again in 2019.

Point spread: Chiefs -12

Pick ATS: Las Vegas

Arizona Cardinals at New York Jets

The woeful Jets didn’t turn the ball over last Thursday night and scored 28 points at home vs. a winless opponent … and still lost by nine. At least New York held a lead for the first time this season, but the defence was a sieve. QB Sam Darnold could be in question for this one with a sprained shoulder. Arizona lost its second in a row to a bad opponent, 31-21 at Carolina. Kyler Murray was held to 133 yards passing but did have three TD passes.

Point spread: Cardinals -6.5

Pick ATS: Arizona

Philadelphia Eagles at Pittsburgh Steelers

Battle of Pennsylvania. The teams do play somewhat regularly in the preseason but just once every four years in a game that counts. The Eagles have taken five of the past six in the series, including the most recent one in a 34-3 home blowout in 2016. The Steelers practiced most of last week but then had a bye week forced upon them when their game vs. the Titans was postponed due to a COVID-19 outbreak with Tennessee. Injury-ravaged Philadelphia was an upset winner Sunday night in San Francisco and now leads the NFC East despite a 1-2-1 record.

Point spread: Steelers -7.5

Pick ATS: Pittsburgh (alternate line of -6.5)

Los Angeles Rams at Washington Football Team

The Rams didn’t play very well Sunday but thankfully for them were facing the horrible Giants and escaped with a 17-9 victory. Star cornerback Jalen Ramsey got into a brawl with New York wideout Golden Tate after the game but apparently won’t face suspension. Washington was without Defensive Rookie of the Year favourite Chase Young due to injury Sunday and lost at home by 14 to Baltimore.

Point spread: Rams -9

Pick ATS: Washington

Cincinnati Bengals at Baltimore Ravens

Matchup of former Heisman Trophy-winning QBs in Cincinnati’s Joe Burrow and Baltimore’s Lamar Jackson. Could be the best rivalry going forward in the AFC North. Burrow had his third straight 300-yard game Sunday and got his first win, 33-25 vs. Jacksonville. Jackson reached 5,000 career yards passing and 2,000 rushing faster than any player ever in Sunday’s ho-hum win at Washington. The Ravens swept the Bengals last year but were pushed at home, 23-17.

Point spread: Ravens -13.5

Pick ATS: Cincinnati (alternate line of +14.5)

Jacksonville Jaguars at Houston Texans

The teams have combined for one victory and both head coaches may be looking for work soon. Making matters worse for the Texans if they earn the No. 1 overall pick in the 2021 draft: They owe their first-rounder to Miami. Houston lost at home to then-winless Minnesota on Sunday, while Jacksonville was beaten handily in Cincinnati. Jacksonville managed 15 total points in being swept by the Texans in 2019.

Point spread: Texans -6.5

Pick ATS: Houston

Miami Dolphins at San Francisco 49ers

The Niners were without several injured starters Sunday night, including quarterback Jimmy Garoppolo and running back Raheem Mostert, and were upset by the Eagles. Not clear yet if either will be back for this one. Fins QB Ryan Fitzpatrick threw two more picks in Sunday’s home loss to Seattle but did enough to hold the starting job for one more week anyway over rookie Tua Tagovailoa.

Point spread: 49ers -8.5

Pick ATS: San Francisco

Indianapolis Colts at Cleveland Browns

The Colts have the NFL’s top-ranked defence and it was on display in Sunday’s 19-11 win in Chicago. However, All-Pro linebacker Darius Leonard left with a groin injury. Definitely monitor that before betting this one. Cleveland won its third in a row Sunday, 49-38 in Dallas, to improve to 3-1 for the first time since 2001. Odell Beckham Jr. had his best game since being traded to the Browns before the 2019 season with three touchdowns, including a spectacular 50-yard reverse that clinched it. However, top running back Nick Chubb is headed to injured reserve with a knee injury.

Point spread: Colts -2.5

Pick ATS: Cleveland

New York Giants at Dallas Cowboys

The NFC East is a hot mess as no teams have more than one victory. The Giants are the only one winless, falling 17-9 at the Rams on Sunday. Daniel Jones threw a crushing interception late deep in Rams territory and has now turned the ball over seven times on the year. He hasn’t thrown a TD pass since Week 2. Dallas is a spectacular offensive team and Dak Prescott threw for a career-high 502 yards on Sunday, but the defence was again ridiculously bad in a 49-38 home loss to Cleveland.  Dallas won both meetings vs. New York last year by at least 18 points.

Point spread: Cowboys -9.5

Pick ATS: Dallas

Denver Broncos at New England Patriots

This was originally scheduled for a 1 p.m. ET start but shifted last week to 4:25 p.m. ET for TV reasons. Denver got its first win of the season last Thursday as undrafted rookie free-agent QB Brett Rypien made his first-ever NFL start. He had three picks but two TD passes and earned another start unless No. 1 Drew Lock is able to get back sooner than expected from a shoulder injury. The Pats’ game Sunday in Kansas City was moved to Monday because New England starting QB Cam Newton tested positive for COVID-19. It’s not likely he will play here but not impossible.

Point spread: Patriots -11

Pick ATS: Denver

Minnesota Vikings at Seattle Seahawks

Sunday night game. The Vikings earned their first win Sunday, 31-23 at Houston. Dalvin Cook rushed for 130 yards and two scores. The Seahawks are 4-0 following a 31-23 win (yep, exact same score as Vikings-Texans) in Miami. Russell Wilson threw for 360 yards and two scores – his 16 TD passes are tied for the most ever in a player’s first four games of a season. Minnesota visited Seattle in a Monday night game in Week 13 a year ago and the Seahawks won 37-30.  Seattle rushed for 218 yards and two scores and also got two TD passes from Wilson. Minnesota had a defensive touchdown but turned it over three times.

Point spread: Seahawks -7

Pick ATS: Seattle (-6.5 alternate line)

Los Angeles Chargers at New Orleans Saints, Monday

This almost surely will be the last time that future Hall of Fame quarterback Drew Brees plays his former Chargers team. He was a second-round pick by them in 2001 and stayed through the 2005 season before leaving in free agency for New Orleans. The Bolts blew a 17-point lead in Tampa on Sunday and lost 38-31, and they lost top running back Austin Ekeler to a multi-week injury. The Saints were down 14-0 in Detroit very early but rallied for a 35-29 win again without injured top wideout Michael Thomas. He probably will play here.

Point spread: Saints -7.5

Pick ATS: New Orleans (-6.5 alternate line)