NFL Week 10 Odds and Predictions: Best Picks Against the Spread
If we are being honest, not really a true marquee matchup on the schedule this week. Dallas is at Green Bay, but of course the Packers have hugely underachieved.

Atlanta Falcons at Carolina Panthers, Thursday
These teams just met in Week 8 and Atlanta won 37-34 in overtime but only because Carolina receiver DJ Moore committed perhaps the stupidest penalty of the season at the end of regulation. Both teams lost on Sunday. Panthers interim coach Steve Wilks pulled a hugely struggling PJ Walker at halftime in Cincinnati and replaced him under centre with Baker Mayfield, but Walker will get the call again Thursday.
Pick ATS: Atlanta (alternate line of -2.5)
Seattle Seahawks at Tampa Bay Buccaneers
It’s the NFL’s first regular-season game in Germany with a 9:30 a.m. ET kickoff. Who would have guessed Seattle would be two games better than Tampa Bay in Week 10? The Seahawks won their fourth game in a row Sunday, 31-21 in Arizona. Geno Smith threw for 275 yards and two touchdowns, while rookie Kenneth Walker III ran for 109 yards and two scores. Tampa Bay should have lost at home Sunday to the Rams but pulled it out 16-13. Tom Brady tossed a 1-yard touchdown pass to rookie Cade Otton with nine seconds remaining. It was Brady’s record 55th game-winning drive.
Pick ATS: Tampa Bay
Minnesota Vikings at Buffalo Bills
The Vikings trailed by 10 at Washington early in the fourth quarter but rallied for a 20-17 win, their sixth straight victory. Greg Joseph hit the winning field goal from 28 yards out with 12 seconds left. In his debut with the team after coming over in trade from Detroit, tight end TJ Hockenson had nine catches for 70 yards. Buffalo was upset 20-17 at the Jets, and quarterback and MVP favourite Josh Allen injured his elbow so that’s obviously something to monitor. That the Bills are -7.5 tells you that oddsmakers think he will play.
Pick ATS: Minnesota

Detroit Lions at Chicago Bears
The Lions had been atrocious defensively but shocked Green Bay 15-9 on Sunday to snap a five-game skid. They picked off Aaron Rodgers three times. Chicago lost 35-32 at home to Miami but clearly has found its quarterback in Justin Fields. He looks like a different player of late and rushed for 178 yards, the most by an NFL quarterback in a regular-season game. The overall record was set by Colin Kaepernick when he ran for 181 yards for San Francisco in a playoff victory over Green Bay during the 2012 season.
Pick ATS: Chicago
Denver Broncos at Tennessee Titans
Massive disappointment Denver comes out of a bye and traded one of its best defensive players in Bradley Chubb last week to Miami. The Broncos are averaging just 15.1 ppg, third-worst in the NFL. Russell Wilson has only six TD passes. The Titans were 14-point underdogs without starting QB Ryan Tannehill on Sunday night but still nearly won in Kansas City, falling 20-17 in OT. Not yet known if Tannehill will be back this week. If not, it will be rookie Malik Willis again.
Pick ATS: Tennessee (alternate line of -2.5)
Jacksonville Jaguars at Kansas City Chiefs
Jacksonville snapped a five-game skid Sunday with a 27-20 win over the Raiders – rallying from down 17-0. It was the second-biggest comeback in franchise history for the Jaguars, who climbed out of a 21-point hole to beat the New York Giants in 2014. Kansas City rallied for a 20-17 OT victory over Tennessee. Patrick Mahomes finished 43 of 68 for 446 yards and a touchdown, and he ran for the tying score and 2-point conversion late in the fourth quarter.
Pick ATS: Kansas City
Cleveland Browns at Miami Dolphins
Cleveland comes out of its bye week – still no Deshaun Watson, though. Watson can’t begin practicing until Nov. 14. But he’ll be eligible to play in Week 13. Miami was a 35-32 winner in Chicago on Sunday and still hasn’t lost with Tua Tagovailoa under centre this year. He threw for 302 yards and three scores. Tyreek Hill had another monster game with seven catches for 143 yards and a score.
Pick ATS: Miami

Houston Texans at New York Giants
Houston lost a third straight game on Thursday in Week 9, 29-17 to the unbeaten Eagles. QB Davis Mills struggled again with only 154 yards and two picks, although he did have two TDs. Dameon Pierce continued his excellent rookie season with 139 yards on 27 carries. New York’s four-game winning streak ended in a 27-13 loss in Seattle on Sunday. Saquon Barkley was held to a season-low 53 yards on 20 carries and had three catches for 9 yards.
Pick ATS: New York
New Orleans Saints at Pittsburgh Steelers
The Saints are on a short week as they hosted the Ravens on Monday night to close Week 9. Receiver Jarvis Landry and Pro Bowl cornerback Marshon Lattimore were out injured. Pittsburgh comes off its bye. Last week, the Steelers traded receiver Chase Claypool to Chicago for a 2023 second-round pick.
Pick ATS: Pittsburgh (alternate line of +3)
Indianapolis Colts at Las Vegas Raiders
The Colts fired coach Frank Reich on Monday, a day after an inept offensive game in a 26-3 loss to New England. In a pretty big stunner, the team has hired their former six-time Pro Bowl centre and ESPN analyst Jeff Saturday as the interim head coach. Saturday has been a consultant for the team and is in its Ring Of Honor. The Raiders blew a 17-0 lead in Jacksonville on Sunday and lost 27-20. Davante Adams blew up with 10 catches for 146 yards and two scores.
Pick ATS: Las Vegas

Dallas Cowboys at Green Bay Packers
The Green Bay offence is simply broken as the Packers lost Sunday 15-9 in Detroit, the team’s fifth straight defeat. This will be the first time that Aaron Rodgers, who had three interceptions, will be a home underdog of more than 3 points. Dallas comes out of its bye week.
Pick ATS: Green Bay
Arizona Cardinals at Los Angeles Rams
Los Angeles won at Arizona 20-12 in Week 3. Matthew Stafford threw for 249 yards, and Cam Akers and Cooper Kupp both scored touchdowns. Kyler Murray had a whopping 58 pass attempts. Arizona lost 31-21 at home to Seattle on Sunday. The Seahawks sacked Kyler Murray four times, including two by Uchenna Nwosu, and held the Cardinals to 262 total yards. The Rams lost 16-13 in Tampa on Sunday. Stafford’s struggles continued as he was 13-fo-27 for just 165 yards.
Pick ATS: Los Angeles (alternate line of -2.5)
Los Angeles Chargers at San Francisco 49ers
Sunday night game. The Niners have absolutely owned the other Los Angeles team in the regular season of late. San Francisco comes off its bye. The Chargers won 20-17 in Atlanta on a field goal as time expired. QB Justin Herbert was without his top two wideouts in Mike Williams (will miss a few more games) and Keenan Allen.
Pick ATS: San Francisco (alternate line of -6.5)
Washington Commanders at Philadelphia Eagles, Monday
The Eagles won at the Commanders 24-8 in Week 3. Jalen Hurts threw for 340 yards and three touchdowns. Carson Wentz was the Washington QB then but won’t be here as he’s still out injured. The Commanders had a three-game winning streak snapped in a 20-17 loss vs. Minnesota on Sunday, blowing a 17-7 fourth quarter lead. Philadelphia remains the NFL’s lone unbeaten and its 8-0 start is the best in team history. It won at Houston on Thursday in Week 9.
Pick ATS: Washington
