NFL Week 10 Odds and Predictions: Best Picks Against the Spread
A Sunday morning game in Germany highlights the NFL this week, and there are four clubs on the bye: Cincinnati, Dallas, Tennessee and Kansas City. Also note the trade deadline is Tuesday afternoon. Below are all Week 10 games with their current NFL odds, played Sunday unless noted.
Las Vegas Raiders at Denver Broncos, Thursday
The Raiders got stellar tight end Brock Bowers back from a multi-game injury absence on Sunday, and it showed as the team scored a season-high 29 points. But they lost again by a point in OT when coach Pete Carroll opted to go for 2 late in the overtime instead of kicking the PAT and taking a tie. Good for him. Denver is on its first six-game winning streak since 2015-16 after yet another comeback win Sunday in Houston, 18-15, on a walk-off field goal. The Broncos have four fourth-quarter comebacks wins in that span and three from down at least 8 points. And Denver won Sunday without superstar corner Patrick Surtain Jr., who is on IR and will miss at least three more games.
Pick ATS: Denver
Atlanta Falcons at Indianapolis Colts
Sunday 9:30 a.m. ET kick in the NFL’s first-ever regular season game in Berlin, Germany. Olympiastadion Berlin did host four NFL exhibition games from 1990-94. The stadium was built for the 1936 Summer Olympics, the Games best known for American track star Jesse Owens. Atlanta got injured QB Michael Penix and WR Drake London back from injury on Sunday and nearly pulled an upset at New England, falling 24-23. Four of Atlanta’s five losses are now vs. teams that missed the playoffs last season. The Colts were probably frauds at 7-1 and exposed Sunday with six turnovers in a 27-20 loss in Pittsburgh. QB Daniel Jones entered with three giveaways all year and had five of the six.
Pick ATS: Indianapolis
New York Giants at Chicago Bears
The Bears won one of the wildest games in franchise history on Sunday, 47-42 in Cincinnati. In doing so, Chicago became the 10th team in NFL history with at least 275 passing and 275 rushing yards in a game. QB Caleb Williams became the first QB in regular-season history to have at least 250 passing yards, three passing TDs and a receiving TD in a game. The Giants lost, 34-24 at home to the 49ers on Sunday, but QB Jaxxon Dart continued to shine as he became the first rookie in league history to have a least one passing and rushing score in four straight games. Both these teams appear to have their young franchise QB.
Pick ATS: Chicago (alt -3)
Buffalo Bills at Miami Dolphins
Many expected the Dolphins to fire embattled head coach Mike McDaniel after Thursday’s embarrassing 28-6 home loss to Baltimore in Week 9, but they kept McDaniel (he will be fired after the season) for now and dumped GM Chris Grier. Miami’s 25-year playoff win drought is the longest active streak in the NFL. The team will be trading guys by Tuesday’s deadline. Possible trap game for Buffalo after a 28-21 win Sunday vs. Kansas City in an AFC title game rematch and potential preview. Josh Allen had his seventh career game with at least 250 passing yards and two rush scores to pass Cam Newton for the most all-time. The Bills beat the Dolphins, 31-21 in Week 3, behind three Allen TD passes.
Pick ATS: Miami (alt +10)
Baltimore Ravens at Minnesota Vikings
Lamar Jackson returned from a three-game injury absence on Thursday in Week 9 and led an easy 28-6 win in Miami. Jackson had just one more incompletion (five) than TD passes (four). Derrick Henry became the eighth player in NFL history with 12,000 career rushing yards and 100 career rush TDs. The Ravens are coming now. Minnesota was a shock winner in Detroit on Sunday, 27-24, as the team improved to 13-0 when leading at halftime since 2024. Rookie QB JJ McCarthy threw for two scores and rushed for one as he played for the first time since Week 2 off injury.
Pick ATS: Baltimore (alt +3)
Cleveland Browns at New York Jets
Both teams are off a bye with the seasons already lost and both may/should sell off some players by Tuesday’s trade deadline. At this point, it would benefit both to lose out in regards to the 2026 draft. Embattled Browns head coach Kevin Stefanski announced Monday that he was relinquishing play-calling duties to offensive coordinator Tommy Rees. Rookie Dillon Gabriel remains the QB. The Jets were the last NFL team to win this season with a wild comeback in Cincinnati in Week 8. Tailback Breece Hall had two TD rushes and the game-winning TD pass and raised his trade value – he might be dealt.
Pick ATS: New York
New England Patriots at Tampa Bay Buccaneers
Potential Super Bowl preview. The Bucs are out of their bye with a two-game lead in the loss column atop the NFC South and with QB Baker Mayfield as an MVP candidate. The team has been ravaged by injuries especially on offence, but most of those guys should be back with the week off. Just not future Hall of Fame wideout Mike Evans, who is out several more weeks with a broken collarbone. New England won its sixth game in a row Sunday, 24-23 over Atlanta, to maintain its lead atop the AFC East. The Pats are the second team ever to start 7-2 or better after back-to-back 13+ loss seasons.
Pick ATS: Tampa Bay
New Orleans Saints at Carolina Panthers
The Saints gave rookie second-round pick Tyler Shough his first start under centre on Sunday, and it went about as well as expected in a 34-10 loss at the Los Angeles Rams. Shough threw for 176 yards with a TD and a pick. New Orleans has now scored fewer than 20 points in seven straight road games. Carolina pulled the largest point-spread upset in the NFL since 2023 as it was +13.5 on Sunday in Green Bay and won 13-10 on a walk-off field goal. The Panthers have become the second team since the merger with a winning record through nine games despite being an underdog in each.
Pick ATS: Carolina
Jacksonville Jaguars at Houston Texans
The Jaguars put rookie dual-threat star Travis Hunter on injured reserve last week and QB Trevor Lawernce was sick Sunday in Las Vegas, but the Jags beat the Raiders, 30-29 in OT, by stopping a two-point conversion try in the final seconds of OT. The Jags’ Cam Little set the NFL record by making a 68-yard field goal during the game. Houston lost starting QB CJ Stroud to a possible concussion in the second quarter and eventually blew a fourth-quarter home lead Sunday and lost to Denver, 18-15. Davis Mills would start if Stroud can’t. Major downgrade. Houston lost, 17-10, in Jacksonville in Week 3.
Pick ATS: Houston
Arizona Cardinals at Seattle Seahawks
Arizona was in Dallas to close Week 9 on Monday night with starting QB Kyler Murray not starting a third straight game due to a foot injury, but the plan was for him to ideally return for this one barring any setbacks. The team was otherwise pretty healthy out of its bye for MNF. Seattle was impressive as anyone Sunday with a 38-14 win at Washington. Wideout Jaxon Smith-Njigba had has fourth straight game with at least eight catches and 120 yards, tied for the NFL’s longest such streak since 1970. He’s on pace for the league’s first 2,000-yard receiving season. Seattle won at Arizona, 23-20, on Thursday night in Week 4. Jason Myers hit the winning 52-yard field goal as time expired.
Pick ATS: Seattle (alt -6.5)
Los Angeles Rams at San Francisco 49ers
If this the week the Niners finally get back No. 1 QB Brock Purdy and WR Ricky Pearsall? The hope was both would get back Sunday from long injury absences but neither did. San Francisco won anyways, 34-24, at the New York Giants. Pretty good chance both return this week, but backup QB Mac Jones started Sunday by going 14-for-14 for 143 yards and two scores in the first half. The Rams might be the NFC’s best team and dominated the visiting Saints on Sunday, 34-10. L.A. has now won three straight games by at least 14 points for the first time since 2017.
Pick ATS: San Francisco
Detroit Lions at Washington Commanders
The Lions were shocked by Minnesota on Sunday, 27-24. They had been unbeaten at home in dominant fashion this year and had not lost a game anywhere when forcing at least one turnover. The Lions finished with season-highs in penalties (10) and penalty yards (76). Jared Goff threw for 284 yards and two touchdowns but was sacked a season-high five times. Washington’s chances of returning to the playoffs sadly ended on Sunday night when the team not only was pummeled at home by Seattle but second-year star QB Jayden Daniels suffered a gruesome elbow injury. He might make it back this season only as it was his non-throwing arm.
Pick ATS: Detroit (alt -7)
Pittsburgh Steelers at Los Angeles Chargers
Sunday night game. Both were playoff teams last season and both are currently in the AFC playoff field. Pittsburgh played arguably its best game of the season Sunday in upsetting AFC-best Indianapolis 27-20 thanks largely to a defence that had been struggling forcing six turnovers. That was the most by the Steelers since 2010. The Chargers were a little sluggish in a potential trap game at the Titans but escaped with a 27-20 victory. Alas, an injury-ravaged offensive line may have lost two more starters.
Pick ATS: Los Angeles (alt -2.5)
Philadelphia Eagles at Green Bay Packers, Monday
Philadelphia comes off its bye week running away with the NFC East title and having been reinforced by trades in the past week or so for cornerbacks Michael Carter II and Jaire Alexander and pass-rusher Jaelan Phillips. Landing Phillips from Miami on Monday was the big one to help bolster a defence that currently ranks 23rd in the NFL in total defence and 24th in sacks. Green Bay was stunned on Sunday at home by Carolina, 13-10, but still leads the NFC North by a half-game. Top tight end Tucker Kraft suffered a season-ending injury in that loss. Green Bay lost 22-10 in Philadelphia in last season’s Wild-Card Round.
Pick ATS: Green Bay
