NFL Spreads Week 4: Best Picks Against the Spread

Ricky Rothstein | Updated Oct 24, 2018


What did we learn in Week 3 of the NFL season? Never bet against the Patriots and Bill Belichick. Jimmy Garoppolo makes his first career start in Week 1 at defending NFC West champion Arizona? No problem, Patriots win. Garoppolo is hurt and rookie Jacoby Brissett makes his first career start Week 3 against defending AFC South champion Houston? No problem, Patriots win big. Who needs Tom Brady?

This will be the final week the Super Bowl favourites will be without the suspended Brady — you know, if he gets his job back. Here’s a quick look at all Week 4 games with Sports Interaction NFL odds. Games on Sunday unless noted. The Packers and Eagles are on the bye.

Thursday Night Football: Week 4

Miami Dolphins at Cincinnati Bengals

Point spread: Bengals -7.5 > Bengals -7

Total: 44.5

Look for a preview of this game later this week. Miami saved its season with a 30-24 home overtime win over a bad Cleveland team on Sunday — a game that shouldn’t have been that close. The Fins might not have tight ended Jordan Cameron for this one as he suffered a possible concussion in the win. Cincinnati is also 1-2 after losing 29-17 at home to Denver.

Pick ATS: Cincinnati

Indianapolis Colts vs. Jacksonville Jaguars (London)

Point spread: Colts -2.5

Total: 49.5

The past two years, the first NFL coach fired has come after a Week 4 loss in London, where this game is being played. And if the winless Jaguars don’t pull out a victory here, Coach Gus Bradley could be gone by Monday. It’s the first of three NFL games in London this season with a 9:30 a.m. ET  kickoff. Indianapolis had a six-game winning streak in this series end in the teams’ final meeting last year, a 51-16 Jaguars home blowout victory. That ended a 16-game winning streak for the Colts in the AFC South, the longest division winning streak in league history. Andrew Luck missed that game injured.

Pick ATS: Jacksonville

Tennessee Titans at Houston Texans

Point spread: Texans -6.5

Total: 40.5

Houston’s offense was inept in Thursday’s 27-0 loss in New England as the Texans didn’t cross midfield until there was less than two minutes to play in the third quarter. Houston had three turnovers that led to 14 Patriots points. Tennessee lost 17-10 at Oakland, turning it over three times. The Titans had appeared to tied it late but Andre Johnson, who caught the apparent tying TD from Marcus Mariota, was called for offensive pass interference. Houston has won four in a row in the series and held the Titans to six points in both games last year.

Pick ATS: Houston

Cleveland Browns at Washington Redskins

Point spread: Redskins -9.5 > Redskins -8

Total: 45.5

This had the potential to be a very interesting game as it was to be Robert Griffin III‘s return to Washington, but of course he’s potentially out for the season with a shoulder injury suffered in Week 1. Rookie QB Cody Kessler made his first career start in Sunday’s 30-24 overtime loss in Miami and played pretty well. But Cody Parkey, who was just signed Saturday, missed the potential winning 46-yard field goal at the end of regulation. Terrelle Pryor became the first Browns player since 1977 to have multiple receptions, rushes and passes in the same game. Washington got its first win with an  upset 29-27 victory at the Giants on a Dustin Hopkins 37-yard field goal with 1:15 to play.

Pick ATS: Cleveland


Seattle Seahawks at New York Jets

Point spread: Seahawks -2.5

Total: 41.5

This opened as a TBA because of the status of Seahawks quarterback Russell Wilson, who left Sunday’s 37-18 win over San Francisco due to what is being called a sprained knee. He was to have an MRI on Monday. If Wilson can’t go, it will be undrafted rookie Trevone Boykin, the former TCU star, under center. Wilson does expect to play. The worst quarterback performance of Week 3 was easily by the Jets’  Ryan Fitzpatrick in a 24-3 loss in Kansas City. He was 20-for-44 for 188 yards and franchise-record tying six interceptions. The Jets turned it over eight times overall.

Pick ATS: Jets

Buffalo Bills at New England Patriots

Point spread: TBA

Total: TBA

So who starts this game for New England at QB? Brissett didn’t put up huge numbers in the win over Houston, completing 11 of 19 passes for 103 yards with a 27-yard touchdown run, but he also didn’t make any mistakes. Brissett was in line to start again but then came news that he suffered a sprained right thumb. So Garoppolo might have to play through his painful shoulder injury. Or maybe Belichick pulls some guy off the street and works his magic. New England has completely dominated Buffalo since 2001, but those were mostly with Brady under center. The Bills might have saved Coach Rex Ryan’s job with a 33-18 home upset over Arizona on Sunday.


Carolina Panthers at Atlanta Falcons

Point spread: Panthers -3

Total: 50.5

This is a payback game of sorts for the Panthers. Their only regular-season loss last year was Week 16 in Atlanta, 20-13. Carolina did not get into the end zone after its opening drive. Cam Newton had arguably his worst game of the season, throwing for only 142 yards, but he did run for a score. Julio Jones killed the Panthers with seven catches for 178 yards, including a 70-yard TD. Carolina was pushed around at home by Minnesota on Sunday, losing 22-10.


Oakland Raiders at Baltimore Ravens

Point spread: Ravens -3.5 > Ravens -3

Total: 46.5 > 46

These teams played Week 2 last year in Oakland and the Raiders won 37-33 on Derek Carr‘s 12-yard touchdown pass to Seth Roberts with 26 seconds remaining. A defensive holding call negated an interception on Oakland’s winning drive. Carr threw for 351 yards and three scores. and Baltimore’s Joe Flacco 384 yards and two TDs.

Pick ATS: Baltimore

Detroit Lions at Chicago Bears

Point spread: Lions -3

Total: 46

Will Chicago get back Jay Cutler for this game? He missed Sunday night’s 31-17 loss in Dallas with a sprained thumb. The winless Bears look like the NFC’s worst team thus far. Detroit has won six straight in the series, although both could have gone the other way in 2015. Detroit’s 24-20 home win over Chicago in Week 17 was the finale for Lions receiver Calvin Johnson, who retired. He had 10 catches for 137 yards and a touchdown and nearly always had big games vs. the Bears.

Pick ATS: Lions

Denver Broncos at Tampa Bay Buccaneers

Point spread: Broncos -3

Total: 44.5

Denver was very impressive in improving to 3-0 with a 29-17 win at Cincinnati on Sunday. Trevor Siemian had the game of his young career in throwing for 312 yards and four touchdowns. No NFL quarterback ever had thrown for 300 yards with four touchdowns and no interceptions in their road debut. Who needs Peyton Manning? Tampa lost 37-32 at home to Los Angeles despite 405 yards and three TDs from QB Jameis Winston.

Pick ATS: Tampa Bay (smells like trap game for Broncos)

Los Angeles Rams at Arizona Cardinals

Point spread: Cardinals -9 > Cardinals -8

Total: 43.5 > 43

If you saw how bad Los Angeles looked Week 1, it’s fairly shocking the Rams are tied for first in the NFC West with a 2-1 record following Sunday’s win in Tampa. Arizona didn’t play well Sunday in being dominated in Buffalo. These teams split last year, with Arizona getting upset at home 24-22 also in Week 4. Todd Gurley rushed for 146 yards for the Rams. Carson Palmer threw for 352 yards and one touchdown, but the Cardinals kept settling for field goals in the red zone. They also turned it over three times.

Pick ATS: Arizona


New Orleans Saints at San Diego Chargers

Point spread: Chargeres -4

Total: 54

This will have extra meaning for Saints quarterback Drew Brees as it’s his first regular-season game in San Diego since the Chargers let him walk as a free agent after the 2005 season so they could turn the team over to a young quarterback named Philip Rivers. While Rivers has had a very good career, that decision in hindsight was a big mistake.

Pick ATS: Saints

Dallas Cowboys at San Francisco Giants

Point spread: Cowboys -3

Total: 46

The Cowboys snapped an eight-game home losing streak Sunday night with a 31-17 win over Chicago. Dallas’ two rookies shined as Ezekiel Elliott rushed for a career-high 140 yards and QB Dak Prescott threw for 248 yards and a TD while rushing for a score. Monitor the status of Dallas star receiver Dez Bryant for this game as he left Sunday with a sprained right knee and was due for an MRI on Monday. San Francisco lost 37-18 in Seattle on Sunday as Blaine Gabbert threw for just 119 yards and a touchdown. Might Chip Kelly go to Colin Kaepernick this week?

Pick ATS: Cowboys

Sunday Night Football: Week 4

Kansas City Chiefs at Pittsburgh Steelers

Point spread: Steelers -5

Total: 47.5

A matchup of last year’s two wild-card teams in the AFC and the Sunday night game this week, so look for an in-depth preview here at Sports Interaction. It will be the season debut of Pittsburgh star running back Le’Veon Bell off his suspension.

Pick ATS: Pittsburgh

Monday Night Football: Week 4

New York Giants at Minnesota Vikings, Monday

Point spread: Vikings -4 > Vikings -5

Total: 43.5

Look for an in-depth preview of this game later in the week. The Giants were blown out at Minnesota in Week 16 last year, 49-17. Not that it likely would have made a difference, but Giants star receiver Odell Beckham Jr. was suspended for that one. The Giants had been eliminated from the playoffs the day before the game so it meant nothing to them.

Pick ATS: New York