NFL Point Spreads Week 4: Best Picks Against the Spread

Payton Matthews | Updated Sep 23, 2019

dak prescott quarterback of dallas cowboys

A thrilling Week 3 of the 2019 NFL season is now in the books, and after Sunday's games, eight teams remain undefeated.

The byes start this week in the NFL with the New York Jets and San Francisco 49ers the first two teams getting a Sunday off. Here’s a quick look at all the Week 4 matchups with Sports Interaction NFL odds. Games Sunday unless noted.

NFL Week 4 Odds

Philadelphia Eagles at Green Bay Packers, Thursday

Excellent matchup to kick off Week 4 between teams that are legitimate contenders – even though the Eagles are 1-2 — to represent the NFC in the Super Bowl. Green Bay is 1-0 in prime time this year and Philadelphia 0-1. The Packers have won five of the past six in this series, including playoffs. They last met in the 2016 regular season.

Point spread: Packers -4.5

Pick ATS: Philadelphia

Tennessee Titans at Atlanta Falcons

The Titans have to be thinking of making a quarterback change after Marcus Mariota struggled again in Thursday night’s loss at Jacksonville and was sacked a whopping nine times. Not all his fault, of course, but it’s just not working with the former Heisman winner. Atlanta was a 27-24 loser at Indianapolis on Sunday. Matt Ryan threw for 304 yards and three scores.

Point spread: Falcons -4

Pick ATS: Atlanta

New England Patriots at Buffalo Bills

A shocking matchup of 3-0 teams – not for the Patriots but for the Bills. Tom Brady has almost never lost to Buffalo in his career, going 30-3 (NFL record for wins by a quarterback vs. one team). Per usual, the Patriots swept in 2018 although the Bills largely made them work for it.

Point spread: Patriots -7.5

Pick ATS: Buffalo

Kansas City Chiefs at Detroit Lions

Could be a bit of a trap game for the Chiefs off a big win over Baltimore and a rare game in a dome for them. It’s the first regular-season indoor game for superstar Patrick Mahomes. The Lions remained unbeaten (one tie) with a 27-24 win in Philadelphia on Sunday. Detroit’s Jamal Agnew had the first kickoff return for a score this season in the NFL.

Point spread: Chiefs -7

Pick ATS: Detroit

Oakland Raiders at Indianapolis Colts

Already been a rough season for these two franchises with both losing superstars: The Raiders cutting loose Antonio Brown and the Colts watching Andrew Luck retire. Oakland was a 34-14 loser at Minnesota on Sunday. The Raiders are in a crazy stretch of six straight weeks without playing a game in Oakland. Indy was a 27-24 winner over Atlanta as Luck replacement Jacoby Brissett threw for 310 yards and two touchdowns. He completed his first 16 passes. Pro Bowl receiver T.Y. Hilton missed the second half because of a quad injury.

Point spread: Colts -6.5

Pick ATS: Indianapolis

LA Chargers at Miami Dolphins

The Dolphins might be the worst team in modern NFL history, losing each of their first three by at least 25 points. It was 31-6 on Sunday in Dallas. Coach Brian Flores made a change at quarterback in going with Josh Rosen, but he completed just 18 of 39. Miami’s minus-117 point differential after three games is the worst in the Super Bowl era. The Chargers were 27-20 home losers to Houston, consistently shooting themselves in the foot. The Bolts were up 10 at the half.

Point spread: Chargers -16.5

Pick ATS: Miami

Washington Redskins at New York Giants

Short week for Washington after hosting Chicago on Monday. The Daniel Jones Era at quarterback for the Giants got off to a roaring start Sunday in Tampa as the rookie threw for 336 yards and two scores and rushed for two touchdowns, including the winner with 1:16 left. However, Pro Bowl running back Saquon Barkley hurt his ankle and will miss some time. These NFC East rivals split last year, each winning on the road.

Point spread: Giants -3

Pick ATS: New York

Cleveland Browns at Baltimore Ravens

The Ravens lost their first game Sunday, 33-28 in Kansas City. Mark Ingram rushed for three scores and quarterback Lamar Jackson one, but he wasn’t all that accurate throwing. The Ravens tried three 2-point conversions and failed on all. Cleveland was a 20-13 home loser to the Rams. Baker Mayfield has been very shaky in the early going and completed just 18 of 36 with a pick. These AFC North rivals split last year, each winning very close at home.

Point spread: Ravens -6

Pick ATS: Baltimore

Carolina Panthers at Houston Texans

Carolina has two wins in their past 10 games. Both with backup QB Kyle Allen under centre. He was in there for an injured Cam Newton on Sunday in a 38-20 victory at Arizona. Allen threw four touchdown passes. Too early to tell if Newton will play this week. Houston was a 27-20 upset winner at the Chargers. Deshaun Watson threw for 351 yards and three touchdowns.

Point spread: Texans -5


Tampa Bay Buccaneers at Los Angeles Rams

Tampa Bay was a 32-31 home upset loser to the Giants on Sunday as kicker Matt Gay missed a 34-yard field goal wide right as time expired. He had made four field goals earlier. Jameis Winston threw for 380 yards and three touchdowns, all to Mike Evans. The Rams are unbeaten following 20-13 win in Cleveland. Jared Goff threw for two scores. L.A. had a goal-line stand in the final minute.

Point spread: Rams -10

Pick ATS: Tampa Bay

Seattle Seahawks at Arizona Cardinals

Seattle was a 33-27 home loser to New Orleans on Sunday despite 406 yards and two touchdowns from Russell Wilson. He also ran for two scores. Seattle had been 15-0 at home in September since 2010. Arizona lost 38-20 at home to Carolina. Kyler Murray threw for only 173 yards and was picked twice. The former Heisman winner did throw for two scores and led the team with 69 yards rushing.

Point spread: Seahawks -4

Pick ATS: Seattle

Minnesota Vikings at Chicago Bears

Chicago on a short week after visiting Washington on Monday. Minnesota has been dominant in its two home wins. It was a 34-14 victor over Oakland on Sunday. Dalvin Cook had his third straight 100-yard game rushing with 110 and a TD on 16 carries. He leads the NFL in rushing. The Bears swept the Vikings last year for the first time since 2011.

Point spread: Bears -3

Pick ATS: Chicago (barring no major injuries Monday)

Jacksonville Jaguars at Denver Broncos

Gardner Minshew Mania has hit the Jacksonville area as the sixth-round rookie played terrific again in last Thursday’s win over Tennessee to save the Jags’ season for now. Will star cornerback Jalen Ramsey still be on the team by this game or will he have been traded? He wants to be gone. Denver is 0-3 and has yet to score more than 16 points.

Point spread: Broncos -3

Pick ATS: Denver

Dallas Cowboys at New Orleans Saints

The Sunday night matchup and would have been one of the marquee NFC games of the season, but it loses some of its luster with the Saints not having future Hall of Fame quarterback Drew Brees for the next six weeks or so. New Orleans visited Dallas last year on a 10-game winning streak and was upset.

Point spread: Saints -3

Pick ATS: New Orleans

Cincinnati Bengals at Pittsburgh Steelers, Monday

Might be the least appealing Monday night game of the season with both clubs winless. That the Bengals are isn’t a surprise. That Pittsburgh is definitely wasn’t expected. Including playoffs, the Steelers have won the past eight against their division rivals.

Point spread: Steelers -4.5

Pick ATS: Cincinnati