NFL Point Spreads Week 17: Best Picks Against the Spread

Payton Matthews | Updated Dec 24, 2018

colts vs titans

The 2018 NFL regular season comes to a close this week with all 16 games Sunday and all of them inter-divisional matchups. More than a few have playoff ramifications.

Here’s a quick look at all the Week 17 matchups with Sports Interaction’s NFL odds.

Miami Dolphins at Buffalo Bills

Meaningless game between AFC East rivals, and could be the last as Dolphins coach for Adam Gase. Think the warm-weather Miami players will be all that excited about playing a late-December game in frigid Buffalo? Dolphins go for season sweep as they beat Bills 21-17 in Week 13. Ryan Tannehill hit Kenny Stills on the game-winning TD pass midway through the fourth quarter.

Point spread: Buffalo -3.5

Pick ATS: Bills

Detroit Lions at Green Bay Packers

Nothing at stake here between NFC North teams. The Packers will have a new coach next time they take the field as interim coach Joe Philbin is finishing off 2018 in place of the fired Mike McCarthy. Green Bay lost in Detroit in Week 5, 31-23, despite 442 yards and three scores from Aaron Rodgers. The Packers’ kicking game was to blame. Our full betting preview of the Lions vs. Packers game can be read here.

Point spread: Green Bay -7

Pick ATS: Packers

Oakland Raiders at Kansas City Chiefs

Who knows where the Raiders, who are on a short week, will be playing in 2019? Not looking like Oakland but a temporary home. The Chiefs claim the AFC West title and No. 1 seed in the conference with a win but could slide all the way to a Wild-Card spot with a loss. Kansas City goes for the season sweep, beating Oakland 40-33 in Week 13 in a game that was closer than expected. Patrick Mahomes threw four TD passes.

Point spread: TBA

Pick ATS: Chiefs

Chicago Bears at Minnesota Vikings

Chicago still has the NFC’s No. 2 seed to play for and would get it with a win and a Rams home loss to San Francisco, which is highly unlikely. Thus, Coach Matt Nagy might rest some guys because the Bears could turn around and host the Vikings on Wild-Card Weekend. The Vikes are a Wild-Card team with a victory. Chicago beat Minnesota 25-20 in Week 11, a game not really as close as the score as the Bears’ defence dominated.

Point spread: Minnesota -6

Pick ATS: Vikings

New York Jets at New England Patriots

The next time the Jets take the field, they will have a new head coach. Todd Bowles won’t be back in 2019. The Patriots are the AFC East champions for a 10th straight season. They will get a first-round playoff bye with a victory here. New England won at the Jets 27-13 in Week 12 but it was tied late in the third quarter.

Point spread: New England -13

Pick ATS: Jets

Carolina Panthers at New Orleans Saints

These teams just played Monday in Week 15 and the Saints won 12-9 in a slugfest. Carolina decided to shut down banged-up quarterback Cam Newton after that loss. No team in league history has started 6-2 and finished 6-10 – which the Panthers would do with a loss. New Orleans probably rests a lot of guys as it wrapped up the NFC’s top seed with Sunday’s comeback win over Pittsburgh. Here’s Sports Interaction’s complete betting preview of this game.

Point spread: TBA

Pick ATS: Panthers

Dallas Cowboys at New York Giants

Absolutely nothing for Dallas to play for as the Cowboys are NFC East champions and the No. 4 seed regardless. Expect Jason Garrett to rest nearly everyone of significance for this one. The Giants are simply playing for draft position. Dallas beat the Giants 20-13 in Week 2 as the Cowboys held New York to 255 yards and sacked Eli Manning six times.

Point spread: NY Giants -7

Pick ATS: Giants

Cincinnati Bengals at Pittsburgh Steelers

Pittsburgh’s only route to the playoffs is to win and have Baltimore lose at home to Cleveland. That would make the Steelers AFC North champs. Should be the last game as Bengals coach for Marvin Lewis. Cincinnati lost home to Pittsburgh in Week 6, 28-21, on a late Antonio Brown TD catch. That really started the Bengals’ downfall as they were 4-1 entering that game.

Point spread: Pittsburgh -14.5

Pick ATS: Bengals

Atlanta Falcons at Tampa Bay Buccaneers

Nothing to see here between NFC South rivals. A loss helps both in terms of potential draft position. Should be last game as Tampa Bay coach for Dirk Koetter. Might be Jameis Winston’s last as the team’s QB. Tampa lost in Atlanta in Week 6, 34-29. That was Winston’s first start of the year off suspension. Read the full preview of this game here.

Point spread: Pick’em

Pick ATS: Bucs

Philadelphia Eagles at Washington Redskins

The Super Bowl champion Eagles’ only chance to have a shot to defend that title is to win and have Minnesota lose at home vs. Chicago. Redskins have nothing to play for. Philadelphia beat Washington 28-13 in Week 13 on Monday night. Carson Wentz threw for 306 yards and two scores, but he’s out for the season now. Washington’s starting QB that night was Colt McCoy, but he left early with a broken leg.

Point spread: Philadelphia -6.5

Pick ATS: Eagles

Cleveland Browns at Baltimore Ravens

Baltimore wins the AFC North with a victory or Pittsburgh loss vs. Cincinnati. Who will be Cleveland’s coach the next time it takes the field? Browns upset the Ravens 12-9 in overtime in Week 5. Just 21 points despite a combined 826 yards offence. It was Cleveland’s first AFC North win in 19 games. Read the complete preview for this matchup here.

Point spread: Baltimore -5

Pick ATS: Ravens

Jacksonville Jaguars at Houston Texans

Houston is at worst a Wild-Card team and clinches the AFC South with a victory. Jacksonville might be making a coaching change this offseason as it was one of the NFL’s biggest disappointments. The Jags lost to the Texans 20-7 in Week 7. Blake Bortles was awful before being pulled by Cody Kessler. In Sunday’s win in Miami, Kessler was pulled for Bortles.

Point spread: Houston -8

Pick ATS: Texans

Los Angeles Chargers at Denver Broncos

Reports are this will be the last game as Broncos coach for Vance Joseph. Priority No. 1 for Denver, after hiring a coach, this offseason is finding a young quarterback. The Broncos stunned the Chargers in L.A. in Week 11, 23-22, on a 34-yard field goal as time expired. Denver is on a short week after visiting Oakland on Monday. The Chargers would be the AFC West champions and conference’s top seed with a win and Chiefs upset loss to Oakland in Week 17. Otherwise, Bolts are a Wild-Card team.

Point spread: TBA

Pick ATS: Chargers

San Francisco 49ers at Los Angeles Rams

The Rams are the NFC’s No. 2 seed with a victory or a Chicago loss in Minnesota. Will Todd Gurley play in this one? He missed the Week 16 win over the Cardinals due to injury. Niners could be really good in 2019 with the return to health of QB Jimmy Garoppolo and a very high first-round draft pick. The Rams routed the 49ers 39-10 in Week 7. San Francisco turned it over four times.

Point spread: LA Rams -9.5

Pick ATS: Rams

Arizona Cardinals at Seattle Seahawks

Reports out of Arizona are that Coach Steve Wilks will be one-and-done as the Cardinals have been so inept on offence that ownership feels the need to make such a drastic change. Seattle won at Arizona 20-17 in Week 4 on a 52-yard field goal as time expired. The Seahawks have little to play for as they are locked into a Wild-Card spot following Sunday night’s upset of the Chiefs.

Point spread: TBA

Pick ATS: Cardinals

Indianapolis Colts at Tennessee Titans

The most important game of Week 17 was flexed to Sunday night as the winner is in the playoffs and the loser is out. Most likely as a Wild-Card team but could be the AFC South champion if Houston is upset at home by Jacksonville. Tennessee was clobbered at Indianapolis in Week 11, 38-10. Colts QB Andrew Luck has never lost to the Titans in 10 tries. Will Tennessee QB Marcus Mariota play? He left Week 16 with a stinger, but with the magnitude of this one, expect him out there. There won’t be a line until his stats is clearer.

Point spread: TBA (for Mariota)

Pick ATS: Colts