Giants vs. 49ers Point Spread: NFL Week 10 Odds, Prediction

David Bastl | Updated Nov 08, 2018

nick mullens

Backup QB Nick Mullens put on a clinic in his first career NFL start this past Thursday night, throwing for 262 yards and three touchdowns.

November 12, 2018, 8:15 PM ET
Levi's Stadium
Pointspread +3 -110
Moneyline +135
Over / Under o +45.5


Betting Action


Pointspread -3 -110
Moneyline -160
Over / Under u +45.5


Betting Action


Three wins total. That’s how many W’s these two teams have combined for this season. To say the season has been a major disappointment for both the Giants and 49ers is a severe understatement. Under the spotlight of Monday Night Football, perhaps one of these teams will break through their dismal years to have a solid remainder of the regular season.

Oddsmakers at Sports Interaction have the 49ers listed as 3-point favourites.

NFL Point Spread and Betting Analysis

Monday night games have been good to the 49ers, as they are 26-6 against the spread in their last 32 games played on that day. However, that’s a wide stretch for this franchise who are 5-14 ATS at home dating back to last season. The Niners are 1-5 ATS in their last six games against their own conference. San Francisco’s two wins have come at home this year, while the Giants lone win was on the road. Head-to-head in this series, the road team and underdog in this match-up is 4-1 ATS in their last five meetings. Of note, these two teams met last year during the regular season (November 12), with the 49ers scoring a 31-21 win at home.

New York Giants

The Giants have one single victory all season long. That happened in week three with a matchup against the Houston Texans. Before that win, and after that win, nothing has really gone right for this team. Coming off a bye, this team should be well-rested for their matchup with the 49ers. This will be an interesting game for the Giants offence, as far as who is on the field. Of course, veteran quarterback Eli Manning will start, but how long will this last? Manning has four wins in his last 25 games as the Giants starter, and with two months to go in a season that has gotten away from them, when do the Giants look at back-up Kyle Lauletta?

New offensive guard Jamon Brown will dress for the team, but no word yet on how much he plays Monday night. Brown was claimed off waivers from the Los Angeles Rams. He goes from blocking for Todd Gurley to Saquon Barkley. Speaking off Barkley, surprisingly, for a team that has one of the most exciting running backs in football Saquon Barkley, it’s hard to figure out how the Giants are ranked 31st in rushing the football, averaging 77.9 yards per game.

San Francisco 49ers

It was all doom and gloom when Jimmy Garoppolo went down with an injury early in the season, but after Thursday’s nights win over the Raiders, people in San Francisco are asking themselves, is Nick Mullens the real deal? If you missed it, Mullens put on a clinic in his first career NFL start this past Thursday night, throwing for 262 yards and three touchdowns. The undrafted pivot out of Southern Mississippi had to step in for the injured CJ Beathard and took advantage of the situation, he’ll get another opportunity in his second consecutive prime-time game.

As always, TE George Kittle was a main target of the receiving core. Kittle hauled in four catches for 108 yards and a touchdown. It wasn’t all good news for the offence in the teams win against the Raiders, as running back Raheem Mosert broke his forearm in the third quarter and will miss the rest of the season. Running back Matt Breida will continue to be the lead back in the 49ers attack. He has 531 yards this season on 96 carries. He leads a 49ers rushing attack that is ranked fourth in the NFL, averaging 134.7 yards per game.

Giants vs. 49ers Prediction