Chargers vs. Bills Point Spread: NFL Week 12 Odds, Prediction

Jeremy Perry | Updated Nov 24, 2020

Josh Allen, Bills. 2020

Will Josh Allen continue his quest for MVP and pick up a win against the Chargers? Allen and Stefon Diggs have been magic this season.

November 29, 2020, 1:00 PM ET
New Era Field
Pointspread +4 -105
Moneyline +182
Over / Under o +51


Betting Action


Pointspread -4 -115
Moneyline -218
Over / Under u +51


Betting Action


At 3-7, the Los Angeles Chargers have had a disappointing season. However, they’ve been close in a lot of losses and are finally coming off a win. They beat the New York Jets 34-28 last Sunday. They now have to take the trip to Buffalo to face off against the Bills, who are currently 7-3 and fully rested after their bye week. Will Josh Allen continue his quest for MVP and pick up another win here or will rookie phenom Justin Herbert get the best of him?

NFL Point Spread and Betting Analysis

The over is 7-0 in the Chargers last seven games overall and 5-0 in their last five when they are coming off an ATS loss. To make the over even more enticing, it is also 4-0 in their last four games as the road underdog. Los Angeles is 4-0 ATS in their past four games in Week 12 and 5-2-1 ATS in their past eight road games against teams with a winning home record.

Meanwhile, the over is 4-1 in the Bills last five home games and 7-2-1 in their past 10 games overall. Buffalo is also 8-1-1 ATS in their last 10 games played in the month of November and 4-1 ATS in their last five games when coming in as the home favorite.

Los Angeles Chargers

The Chargers haven’t had the level of success that they were hoping for when the season first began. Much of that underachieving has been due to the team suffering various injuries across their offense and defense. But the injury to quarterback Tyrod Taylor has unleashed the beast in rookie quarterback Justin Herbert. He’s taken this entire offense to new heights and has been proving week after week that he is the runaway for the Offensive Rookie of the Year award. He’s ranked sixth in touchdown passes (22) but he’s only played nine games. He’s thrown for over 300 yards in three of his last five and has tossed 17 touchdowns and just three interceptions in his last six contests.

The Chargers will be able to compete with anybody with Herbert running the show at quarterback because he now has their offense ranked third in the NFL. Their defense has been their downfall this season, but they are still a solid group behind leaders Joey Bosa and Melvin Ingram. Ultimately, they are going to have to improve on closing games out because this game has a very high possibility of coming down to the last possession.

Buffalo Bills

Buffalo has struggled on the defensive side of the ball a lot this season but that comes as a surprise due to the talent they have back there. This defensive unit hasn’t played up to the level that they played last season, allowing far too many big plays to the opposing offense. The run defense has been a letdown as they 28th in the NFL but the good news is the Chargers are not a good rushing team.

The Bills offense should feast this week against a Chargers defense that nearly blew it against the Joe Flacco-led New York Jets last week. The offseason trade they made for Stefon Diggs has given Josh Allen a shiny new weapon that he hasn’t had the last few seasons. This should be a high-scoring affair but they’re the better team here, so expect them to win.

Who Will Win Chargers vs. Bills?