Browns vs. 49ers Point Spread: NFL Predictions, Week 5 Odds

Payton Matthews | Updated Oct 07, 2019

Baker Mayfield, Cleveland Browns, 2019

Baker Mayfield responded to critics with an outstanding game in Week 4 throwing for 342 yards and a touchdown. Can the Browns upset the undefeated 49ers this week?

October 07, 2019, 8:15 PM ET
Levi's Stadium
Pointspread +4.5 -119
Moneyline +160
Over / Under o +48


Betting Action


Pointspread -4.5 -101
Moneyline -192
Over / Under u +48


Betting Action


Yet another prime-time game for the Cleveland Browns as they close out Week 5 on Monday night in visiting the well-rested San Francisco 49ers.

NFL Point Spread and Betting Analysis

Want proof the NFL schedule-makers and TV network executives bought into the Cleveland Browns’ hype entering this season? They are scheduled to make five prime-time appearances, which is the most any team is allowed to be scheduled (flex scheduling later in the year can add them). The Browns are 1-1 in them in 2019, winning Monday night Week 2 at the sorry Jets and then losing Sunday night in Week 3 to the Rams.

This is also Cleveland’s first-ever visit to the 49ers’ Levi’s Stadium as San Francisco is hosting Cleveland for the first time since 2011 before Levi’s Stadium was complete. In fact, it’s the first time the Niners ever have hosted the Browns on MNF.

One interesting story line here is current Niners quarterback Jimmy Garoppolo. Former Browns front office officials and coaches were completely enamored with Jimmy G when he was a backup for the Patriots. In late October 2017, the Patriots shipped Garoppolo to the 49ers for just a second-round pick even though it was common knowledge the Browns were willing to offer a 2018 first-round pick that they owned from Houston – that turned out to be No. 4 overall. Apparently, though, Bill Belichick froze out every suitor but the 49ers because he was so angry that ownership was making him trade Jimmy G.

The total has gone under in the past four between these teams.

Cleveland Browns

Cleveland was an impressive 40-25 winner in Baltimore on Sunday. Baker Mayfield threw for 342 yards and a touchdown, while Nick Chubb rushed for 165 yards and three scores, including an 88-yarder against one of the NFL’s top rushing defences. Jarvis Landry had eight catches for a career-high 167 yards but left with a possible concussion. Top cornerbacks Denzel Ward and Greedy Williams and tight end David Njoku all sat with injuries. Njoku won’t play here. The Browns will get receiver Antonio Callaway back off a four-game suspension. Cleveland is 0-6 ATS in its past six following a win of at least 14 points.

San Francisco 49ers

The Niners are on about as much rest as an NFL team can get in playing on a Monday night off a bye week. Coaches hate bye weeks this early. San Francisco is off to a 3-0 start because its defence has been tremendous, yet to allow more than 20 points. That unit has lost cornerback Akhello Witherspoon for at least a month due to a right foot strain, though. He has been very good in the early season. Garoppolo has been a bit inconsistent after missing much of the 2018 season injured, completing 60 per cent for 739 yards, five touchdowns and four interceptions. Running back Tevin Coleman has missed the past two games with an ankle injury but could return Monday. The Niners have failed to cover their past six after a bye week.

Who Will Win Browns vs. 49ers?