The 49ers are coming off a stunning 31-10 upset win over the Los Angeles Rams, and are vying for their fourth away victory of the season on Sunday afternoon. The Jaguars are coming off a 23-17 loss in Indianapolis, but have claimed victory in each of their past two home dates.

The Niners are 6.5-point favourites to win on the NFL odds, with a total of 45.0.

NFL Point Spread and Betting Analysis

The point spread has fluctuated since opening with the 49ers pegged as 5.5-point favourites. Backed by 70 per cent of sports bettors, the Niners improved to 7.5-point chalk before settling back to their current position at -6.5. With both these teams recently turning in steady defensive performances, the total has faded to 45.0 since opening at 46.5, with 68 per cent of bets backing the UNDER.

Sunday afternoon’s matchup at TIAA Bank Field marks the first meeting between these two teams since December 2017. The 49ers have marched to three straight head-to-head wins while claiming victory by an average margin of 20 points, including a 42-10 rout in their last visit to Jacksonville eight years ago. The Niners have also dominated at the sportsbooks, covering in four straight meetings with the Jaguars. More important is San Francisco’s recent road success. The 49ers sport a 3-1 straight up road record this season, including a pair of outright wins as underdogs. However, the Jaguars have also impressed while posting two straight upset wins on home turf, capped by a 9-6 win over Buffalo as 14.5-point underdogs two weeks ago.

San Francisco 49ers

The 49ers signalled their intent to get back into the NFC playoff race with last week’s win over the Rams. San Francisco has now won two of three to end a four-game slide, while averaging 27 points per game. San Francisco rushers have tallied four scores over their past three games, and have easily exceeded 100 total rushing yards in four of five outings. However, injuries in the backfield have emerged as a concern. Elijah Mitchell and JaMycal Hasty both missed Wednesday practice due to injury. They were joined in the clinic by the team’s top receiver Deebo Samuel, who sat out Wednesday with a leg injury after claiming NFC Offensive Player of the Week honours for his efforts in last weekend’s win over the Rams.

Jacksonville Jaguars

All eyes have been on quarterback Trevor Lawrence in his NFL debut with Jacksonville this season. And with good reason. The top pick in this year’s NFL Draft showed flashes of his vast potential while tossing for eight scores in his first seven outings. However, it has been the Jaguars defence that has captured the spotlight while allowing just one total offensive touchdown over their past two outings. The Jags turned in a particularly stingy performance against the Super Bowl favourite Bills, intercepting quarterback Josh Allen on two occasions in a 9-6 win. And while they allowed the Colts to jump out to a 17-0 lead last weekend, they limited the Colts to 11 or fewer yards in eight of their subsequent 10 possessions.

NFL Prediction: Who Will Win 49ers vs. Jaguars?

• Regular Season
• Playoffs

49ers Team Leaders

SF

Touchdowns	Deebo Samuel 15
Rushing	Elijah Mitchell 963
Passing	Jimmy Garoppolo 3810
Receiving	Deebo Samuel 77
Sacks	Nick Bosa 15.5
Interceptions	Jimmie Ward 2

JAC

Touchdowns	James Robinson 8
Rushing	James Robinson 767
Passing	Trevor Lawrence 3641
Receiving	Marvin Jones Jr. 73
Sacks	Josh Allen 7.5
Interceptions	Tyson Campbell 2

SF

Touchdowns	Deebo Samuel 2
Rushing	Elijah Mitchell 169
Passing	Jimmy Garoppolo 535
Receiving	Deebo Samuel 10
Sacks	Nick Bosa 4
Interceptions	K'Waun Williams 1

JAC

Touchdowns
Rushing
Passing	Did not qualify
Receiving
Sacks
Interceptions

• Regular Season
• Playoffs

Jaguars Team Leaders

SF

Touchdowns	Deebo Samuel 15
Rushing	Elijah Mitchell 963
Passing	Jimmy Garoppolo 3810
Receiving	Deebo Samuel 77
Sacks	Nick Bosa 15.5
Interceptions	Jimmie Ward 2

JAC

Touchdowns	James Robinson 8
Rushing	James Robinson 767
Passing	Trevor Lawrence 3641
Receiving	Marvin Jones Jr. 73
Sacks	Josh Allen 7.5
Interceptions	Tyson Campbell 2

SF

Touchdowns	Deebo Samuel 2
Rushing	Elijah Mitchell 169
Passing	Jimmy Garoppolo 535
Receiving	Deebo Samuel 10
Sacks	Nick Bosa 4
Interceptions	K'Waun Williams 1

JAC

Touchdowns
Rushing
Passing	Did not qualify
Receiving
Sacks
Interceptions

Weather

temp	67
condition	sunny
wind	Southwest 12mph

Injuries

San Francisco

Demetrius Flannigan-Fowles (LB)

day-to-day Knee - 30 / 01 / 22

Dre Greenlaw (LB)

day-to-day Calf - 30 / 01 / 22

Arden Key (DL)

day-to-day Head - 30 / 01 / 22

Jimmy Garoppolo (QB)

Prob Sun Thumb - 26 / 01 / 22

Jeff Wilson Jr. (RB)

Ques Sun Ankle - 26 / 01 / 22

Elijah Mitchell (RB)

Prob Sun Knee - 26 / 01 / 22

Jeff Wilson Jr. (RB)

Ques Sun Ankle - 22 / 01 / 22

Azeez Al-Shaair (LB)

Prob Sat Knee - 19 / 01 / 22

Dre Greenlaw (LB)

Prob Sat Groin - 19 / 01 / 22

Ambry Thomas (CB)

Prob Sun Knee - 19 / 01 / 22

Jacksonville

C.J. Beathard (QB)

Out indefinitely Illness - 07 / 01 / 22

Chapelle Russell (LB)

Out indefinitely Illness - 06 / 01 / 22

Myles Jack (LB)

Prob Sun Knee - 05 / 01 / 22

JK Scott (P)

Out indefinitely Illness - 05 / 01 / 22

Dawuane Smoot (DE)

Out indefinitely Illness - 01 / 01 / 22

Nevin Lawson (DB)

Ques Sun Illness - 01 / 01 / 22

Shaquill Griffin (CB)

Out indefinitely Illness - 31 / 12 / 21

Andrew Wingard (S)

Out indefinitely Illness - 30 / 12 / 21

Rudy Ford (S)

Out indefinitely Illness - 29 / 12 / 21

James O'Shaughnessy (TE)

Out Sun Hip - 29 / 12 / 21

Injuries

San Francisco

player (position)	status		ats*current	o/u*	notes
Demetrius Flannigan-Fowles (LB)	day-to-day	Knee - 30 / 01 / 22	1-0	0-1	+ -
Flannigan-Fowles was removed from the NFC championship game due to a knee injury, and it is unclear if he will return.
Dre Greenlaw (LB)	day-to-day	Calf - 30 / 01 / 22	1-0	0-1	+ -
Greenlaw exited the NFC championship contest due to a calf injury, and it is up in the air if he will return.
Arden Key (DL)	day-to-day	Head - 30 / 01 / 22	1-0	0-1	+ -
Key exited the NFC championship game due to a head injury, and it is unknown if he will return.
Jimmy Garoppolo (QB)	Prob Sun	Thumb - 26 / 01 / 22	1-0	0-1	+ -
Garoppolo is expected to take on the Rams in the NFC championship despite lingering thumb and shoulder injuries.
Jeff Wilson Jr. (RB)	Ques Sun	Ankle - 26 / 01 / 22	1-0	0-1	+ -
Wilson Jr. has a low-ankle sprain, and it is unknown if he will take part in the NFC championship versus the Rams.
Elijah Mitchell (RB)	Prob Sun	Knee - 26 / 01 / 22	1-0	0-1	+ -
Mitchell is hampered by a knee injury, but it is not expected to affect his status for the NFC championship versus the Rams.
Jeff Wilson Jr. (RB)	Ques Sun	Ankle - 22 / 01 / 22	2-0	0-2	+ -
Wilson Jr. is hobbled with an ankle injury, and it is unclear if he will hit the field against the Rams for the NFC championship game.
Azeez Al-Shaair (LB)	Prob Sat	Knee - 19 / 01 / 22	2-0	0-2	+ -
Al-Shaair has a knee injury, but it is projected that he will take on the Packers in the NFC divisional round.
Dre Greenlaw (LB)	Prob Sat	Groin - 19 / 01 / 22	2-0	0-2	+ -
Greenlaw is managing a groin issue, but it is likely that he will be available for the NFC divisional round versus the Packers.
Ambry Thomas (CB)	Prob Sun	Knee - 19 / 01 / 22	2-0	0-2	+ -
Thomas is battling a knee injury, but it is anticipated that he will suit up versus the Rams for the NFC championship game.

Jacksonville

player (position)	status		ats*current	o/u*	notes
C.J. Beathard (QB)	Out indefinitely	Illness - 07 / 01 / 22	0-1	1-0	+ -
Beathard has been added to the IR/COVID-19 list, and it has yet to be decided when he will return to action.
Chapelle Russell (LB)	Out indefinitely	Illness - 06 / 01 / 22	0-1	1-0	+ -
Russell will miss an undetermined length of time after winding up on the COVID-19 list.
Myles Jack (LB)	Prob Sun	Knee - 05 / 01 / 22	0-1	1-0	+ -
Jack is dealing with a knee injury, but it is anticipated that he will take on the Colts on Sunday.
JK Scott (P)	Out indefinitely	Illness - 05 / 01 / 22	0-1	1-0	+ -
Scott has been shifted to the IR/COVID-19 list, and it is unknown when he will return.
Dawuane Smoot (DE)	Out indefinitely	Illness - 01 / 01 / 22	0-2	2-0	+ -
Smoot will miss an undetermined length of time after winding up on the COVID-19 list.
Nevin Lawson (DB)	Ques Sun	Illness - 01 / 01 / 22	0-2	2-0	+ -
Lawson sat out the last contest due to an illness, and it is undecided if he will be available for Sunday versus the Colts.
Shaquill Griffin (CB)	Out indefinitely	Illness - 31 / 12 / 21	0-2	2-0	+ -
Griffin has been shifted to the IR/COVID-19 list, and it is unknown when he will return.
Andrew Wingard (S)	Out indefinitely	Illness - 30 / 12 / 21	0-2	2-0	+ -
Wingard has been shifted to the IR/COVID-19 list, and it is unknown when he will return.
Rudy Ford (S)	Out indefinitely	Illness - 29 / 12 / 21	0-2	2-0	+ -
Ford will miss an undetermined length of time after winding up on the COVID-19 list.
James O'Shaughnessy (TE)	Out Sun	Hip - 29 / 12 / 21	0-2	2-0	+ -
O'Shaughnessy sat out the last contest due to a hip injury, leaving his status against the Colts on Sunday as unavailable.