49ers vs. Eagles Point Spread: NFL Week 2 Odds, Prediction

Jordan Ramsay | Updated Sep 15, 2021

The Jalen Hurts era in Philadelphia got off to a great start in Week 1, but the Eagles are about to face a much tougher test in the San Francisco 49ers on Sunday.

September 19, 2021, 1:00 PM ET
Lincoln Financial Field
Pointspread -3 -102
Moneyline -149
Over / Under o +49


Betting Action


Pointspread +3 -118
Moneyline +124
Over / Under u +49


Betting Action


It’s an NFC West versus NFC East matchup on Sunday as the San Francisco 49ers will travel to Philadelphia to take on the Eagles.  The 49ers are on the road again after taking down the Lions 41-33 in Detroit in Week 1.  The Eagles are playing their home opener following a 32-6 pounding of the Falcons in Atlanta.  Which team will improve to 2-0 on the season?

San Francisco is a 3.5-point road favourite to win on the NFL odds, with a total of 50.0.

NFL Point Spread and Betting Analysis

Philadelphia has taken the last two games between these teams, but they only met once in 2020.  The Eagles won 25-20 in San Francisco, but neither starting quarterback from that game (Carson Wentz now in Indianapolis, Nick Mullens now in Cleveland) is still around.  Sports Interaction bettors aren’t expecting the same result this week, with 81 per cent of action going to the 49ers.

Neither team was a great cover option in 2020.  San Francisco was favoured by 3.5-points or more five times last season, but only managed to cover the spread in one of those games.  They finished the season 7-9 against the spread overall.  The Eagles were 5-3 ATS last season when they were dogs of 3.5 points or more, but they finished the year 6-10 ATS overall.

San Francisco and Philadelphia each played five games with a total above 50 last year.  Eight of the 49ers’ games hit the Over last season, while the Eagles went above the number seven times.  Bettors are banking on a high scoring game on Sunday, with just over 70 per cent of action taking the Over.

San Francisco 49ers

It’s was flashbacks of last year’s injury-riddled season for San Francisco in Week 1 as their win came at a price.  The 49ers will be without running back Raheem Mostert and cornerback Jason Verrett for the year after both players suffered season-ending knee injuries against Detroit.  It was originally announced Mostert would miss eight weeks with chipped cartilage in his knee before it was decided he would need season-ending surgery.  Verrett tore the ACL in his right knee.  Rookie Elijah Mitchell filled in for Mostert, finishing with 104 rushing yards, including a 38-yard tiebreaking touchdown run.

As for the rest of the game, quarterback Jimmy Garoppolo finished 17-for-25 passing, with 314 yards and a touchdown.  Garoppolo is going to face constant pressure from rookie Trey Lance for the starting job.  Lance, the No. 3 pick in the 2021 draft, is widely expected to eventually be the starter in San Francisco and even connected on a five-yard touchdown pass in his only passing attempt of the game.

Philadelphia Eagles

The Jalen Hurts era in Philadelphia officially kicked off in Week 1 and it couldn’t have got off to a much better of start.  Hurts threw three touchdown passes and finished 27-for-35 passing with 264 yards, connecting at least twice with seven different players.  He also ran for another 62 yards and was only sacked once.  Hurts hit Heisman Trophy winner and 2021 10th overall draft pick DeVonta Smith with an 18-yard pass for his first career touchdown.  Smith wasn’t the only rookie to pick up his first career touchdown.  Fifth-round pick Kenneth Gainwell ran in an eight-yard score, finishing the day with 37 rushing yards.

The defence was also impressive against the Falcons.  After allowing 363.1 total yards and 26.1 points per game in 2020, the Eagles held Atlanta to just 260 total yards and six points.  Javon Hargrave had two of Philadelphia’s three sacks on the day, both on fourth-down plays in the closing minutes.

NFL Prediction: Who Will Win 49ers vs. Eagles?