49ers vs. Cardinals Point Spread: NFL Week 16 Odds, Prediction

Sports Interaction Staff | Updated Dec 23, 2020

Kyler Murray and Christian Kirk, Cardinals, 2020

The Cardinals control their own playoff destiny. With a win over the 49ers this week and a win over the Rams next week, they will earn a spot in the post season.

December 26, 2020, 4:30 PM ET
State Farm Stadium
Pointspread +7 -110
Moneyline +255
Over / Under o +49


Betting Action


Pointspread -7 -110
Moneyline -309
Over / Under u +49


Betting Action


Injuries have wreaked havoc on the 49ers all season, culminating in a loss to an equally injury riddled Cowboys team, last week, and things won’t get any easier on the road against an Arizona team looking to take one step closer to punching their ticket to the playoffs.  The Cardinals are 5-point favourites on the NFL odds with a total of 49.

NFL Point Spread and Betting Analysis

These teams opened the season against each other in San Francisco back in Week 1, before Covid-19 restrictions forced the 49ers to move their homes games out of San Francisco, although there is no issue this week as it’s an Arizona home game.  In the 24-20 Cardinals win, Kyler Murray threw for 230 yards and a TD, while also picking up 91 yards and another TD on the ground.

The over is 5-0 in the Cardinals last five home games and 5-1 in the 49ers last six Saturday games, which could explain why, so far, 77 per cent of Sports Interaction bettors have taken the over on the total of 49.

Arizona has been playing like a playoff team all season and has gone 4-1 against the spread in their last five games against teams with a losing record, while the 49ers are in the opposite boat, going 1-6 ATS in their last seven games overall.

San Francisco 49ers

The 49ers have come a long way from the team that almost beat the Kansas City Chiefs in the Super Bowl 10 months ago and not in a good way.  A disastrous season turned even worse when San Francisco QB Nick Mullens suffered an elbow injury and was ruled out for the season after the 49ers 41-33 loss in Dallas, last week.  Mullens took over after starter Jimmy Garoppolo’s season also ended early when he suffered an ankle injury in Week 8.  Combined, Mullens and Garoppolo have thrown 19 TDs and 17 interceptions, this year.  C.J. Beathard, who hasn’t started since Week 8 of the 2018 season, will get the nod at QB on Saturday.

The ground game for the 49ers is averaging 112.6 rushing yards per game, led by Raheem Mostert’s 521 rushing yards and two TDs.  Defensively, San Francisco is giving up 25.1 points per game and 314.3 yards per game.  Fred Warner leads the 49ers with 101 tackles, while Kerry Hyder’s 7.5 sacks and Jamar Taylor’s two interceptions are also team-bests.

Arizona Cardinals

It’s pretty simple for the Cardinals:  a win this week against the 49ers and another win next week against the Rams puts them in the playoffs.  They’ve been rolling lately and are coming off wins over the Giants and Eagles, with Kyler Murray completing 67.8 per cent of his passes for 3,637 yards, 26 TDs and 11 interceptions, including seven TDs in Murray’s last three games.

DeAndre Hopkins and Christian Kirk have combined for 1,869 receiving yards and 12 TDs and the Arizona run-game is averaging 147.8 rushing yards per game.  The Cardinals have been allowing 23.5 points per game and give up 350 yards per game, with the defence being led by Jordan Hicks, who has a team-high, 107 tackles, Haason Reddick, who has a team-high 11 sacks, and Patrick Peterson, who leads the team with three interceptions.

Who Will Win 49ers vs. Cardinals?