49ers vs. Bengals Point Spread: NFL Week 14 Odds, Prediction

Jordan Ramsay | Updated Dec 09, 2021

With both teams clinging to wild-card spots in their respective conferences, it will essentially be a must-win game when the Cincinnati Bengals host the San Francisco 49ers on Sunday.

December 12, 2021, 4:25 PM ET
Paul Brown Stadium
Pointspread -2 -110
Moneyline -130
Over / Under o +49.5


Betting Action


Pointspread +2 -110
Moneyline +108
Over / Under u +49.5


Betting Action


As the 2021 season comes down to the final stretch in the NFL, every game becomes that much more important, as will be the case when the Cincinnati Bengals host the San Francisco 49ers on Sunday.  The Bengals were never close last week in their 41-22 blowout loss against the Chargers.  San Francisco is also coming off a loss, falling 30-23 to division rival Seattle.

This games continues to inch closer to a pick’em, though for the time being Cincinnati is a 1.5-point favourite to win on the NFL odds, with a total of 48.5.

NFL Point Spread and Betting Analysis

The last time these teams met, the 49ers crushed the Bengals 41-17 in Cincinnati in 2019.  San Francisco quarterback Jimmy Garoppolo threw for 296 yards and three touchdowns, while Bengals quarterback Joe Burrow was still in college at the time.  Early action has about 55 per cent of Sports Interaction bettors taking Cincinnati for this one, while 77 per cent of bettors are taking the Over.

The 49ers have historically dominated this all-time series, winning 12 of the last 15 games.  They haven’t been a great cover option this year, going 5-7 against the spread overall, although they have managed to cover in four of their last six games.  The total has gone Over in five of San Franciscos’s last six games.

Cincinnati has been average at home this year, going 3-3 at Paul Brown Stadium.  They’re 6-6 ATS overall, but have only covered in one of their last five home games.  The total has gone Over in five of the Bengals’ last six games.

San Francisco 49ers

The 49ers have been surprisingly good in the East Coast, winning their last six trips across the country by an average of more than 17 points.  Tight end George Kittle was the star for San Francisco last week, finishing with 181 receiving yards and two touchdowns on nine catches.  Kittle became just the second tight end in the last five seasons to finish the first half of a game with at least 100 receiving yards and two TDs.  Garoppolo threw for 299 yards and two TDs last week, but he was also picked off twice.

As far as injury news, wide receiver Deebo Samuel missed last week’s game with a groin injury.  There’s been no update on Samuel’s status for this week, although it doesn’t look like it’s a serious injury, so there’s a chance he’s in the lineup.  Linebackers Fred Warner (hamstring) and Marcell Harris (concussion) also missed the Seattle game.  Warner and Harris both returned to practice this week and will likely play on Sunday.  Cornerback Emmanuel Moseley is expected to miss several weeks after suffering a high ankle sprain last week.

Cincinnati Bengals

It wasn’t a great performance from Burrow last week.  The second-year QB threw for 300 yards and a touchdown, but he was also picked off twice.  Burrow was sacked six times and played most of the game with a dislocated pinky on his throwing hand, although it’s not expected to change his status this week.  The Bengals are 0-4 this season when Burrow throws multiple interceptions.  The duo of running back Joe Mixon and wide receiver Ja’Marr Chase has carried the offence this year.  Mixon and Chase account for 22 of Cincinnati’s 40 touchdowns.

NFL Prediction: Who Will Win 49ers vs. Bengals?