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Lions vs. Bills Prediction, Odds & Stats September 17, 2026

Game Scheduled
NFC North
Sep 17th, 8:15 PM EDT
Detroit
Lions
W W L
Buffalo
Bills
W W W
VS
Detroit Lions
Buffalo Bills
Scoreboard Spread Moneyline O/U
Detroit Lions 0-0 - - -
Buffalo Bills 0-0 - - -
Loading odds...

Latest Encounters

Date Result Competition Stats Recap
08/29/26
Detroit Lions DET ( 0-0 )
Indianapolis Colts IND ( 0-0 )
25   -   16
 NFC North
08/27/26
Pittsburgh Steelers PIT ( 0-0 )
Buffalo Bills BUF ( 0-0 )
27   -   28
 AFC North
08/22/26
Buffalo Bills BUF ( 0-0 )
Cleveland Browns CLE ( 0-0 )
31   -   7
 AFC East

Line History

Matchup Details

Detroit Lions DET
Buffalo Bills BUF
Stat
0 Games Won 0
0 Games Lost 0
0-0-0 Last 10 0-0-0
0-0 W L Streak 0-0
0-0 Against The Spread 0-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
0-0 Total 0-0

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards DET:Total Net Yards DET:Net Rushing Yards DET:Passing Yards
12/15/2024 DET 42 - BUF 48 BUF +2.5 Over 56 559 197 362 521 48 473
11/24/2022 DET 25 - BUF 28 DET +9 Under 54.5 401 164 237 326 96 230
08/13/2021 DET 15 - BUF 16 BUF -2 Under 36.5 259 114 145 248 107 141
08/23/2019 DET 20 - BUF 24 BUF +1 Over 41.5 350 147 203 317 105 212
12/16/2018 BUF 14 - DET 13 DET +1 Under 40 313 105 208 312 117 195
08/31/2017 BUF 27 - DET 17 BUF +3.5 Over 35.5 317 100 217 327 205 122
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
08/29/2026 IND 16 - DET 25 W +1 Over 36.5 356 186 170
08/22/2026 DET 17 - WAS 13 W -1.5 Under 36.5 243 35 208
08/13/2026 CIN 16 - DET 14 W +7 Under 38 274 129 145
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
08/27/2026 BUF 28 - PIT 27 L -1 Over 35 266 89 177
08/22/2026 CLE 7 - BUF 31 W +1 Under 39.5 194 84 110
08/15/2026 BUF 29 - CAR 14 W +1 Over 38 420 151 269

Matchup Edge - Scoring Stats

Detroit Lions DET
Buffalo Bills BUF
avg rank edge in rank avg
2.1 1 Qb Rating 1 2.1

Odds Analysis

Team Rankings

Detroit Lions DET
Season stats rank
Total Yards 0 13
Passing Yards 0 16
Rushing Yards 0 13
Points Scored 0 16
Field Goal % 0 17
Buffalo Bills BUF
Season stats rank
Total Yards 0 22
Passing Yards 0 7
Rushing Yards 0 22
Points Scored 0 7
Field Goal % 0 8
Detroit Lions DET
Season stats rank
Total Yards 0 20
Passing Yards 0 20
Rushing Yards 0 20
Points Scored 0 20
Field Goal % 0 17
Buffalo Bills BUF
Season stats rank
Total Yards 0 11
Passing Yards 0 11
Rushing Yards 0 11
Points Scored 0 11
Field Goal % 0 26

Injuries

Detroit Lions DET
Buffalo Bills BUF

Detroit vs. Buffalo Betting News

Detroit Lions DET

No posts found.
Buffalo Bills BUF

No posts found.

Detroit Vs Buffalo Betting Trends

Detroit Lions DET

Lions are 5-1 ATS in their last 6 games as a road underdog of 3.5-10.0.

Over is 5-2 in Lions last 7 Thursday games.

Over is 6-1 in Lions last 7 games as a favorite.

Over is 38-18-1 in Lions last 57 games on fieldturf.

Over is 5-1 in Lions last 6 games in Week 2.

Buffalo Bills BUF

Under is 4-1 in Bills last 5 games as a home underdog of 3.5-10.0.

Bills are 4-1 ATS in their last 5 games as a home underdog of 0.5-3.0.

Over is 4-0 in Bills last 4 games as a home favorite of 10.5 or greater.

Under is 8-1 in Bills last 9 Thursday games.

Over is 4-1 in Bills last 5 games as a favorite.

National Football Conference Standings

American Football Conference Standings

Line Up - Last Game

Detroit Lions
Pitchers
POS Player
Hitters
POS Player
Buffalo Bills
Pitchers
POS Player
Hitters
POS Player
  • DET
  • +3 -3
  • BUF
Odds