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Colts vs. Bills Prediction, Odds & Stats November 21, 2021

Final Score
AFC South
Nov 21st, 1:00 PM EST
Indianapolis
Colts
Buffalo
Bills
41
15
Indianapolis Colts
Buffalo Bills
60%
40%
Betting Action
Scoreboard 1 2 3 4 Odds
Indianapolis Colts 9-8 14 10 14 3 +49.5
Buffalo Bills 11-6 0 7 0 8 -7.5

Latest Encounters

Date Result Competition Stats Recap
01/23/22
Buffalo Bills BUF ( 11-6 )
Kansas City Chiefs KC ( 12-5 )
36   -   42
 AFC East
01/15/22
New England Patriots NE ( 10-7 )
Buffalo Bills BUF ( 11-6 )
17   -   47
 AFC East
01/09/22
N.Y. Jets Jets NYJ ( 4-13 )
Buffalo Bills BUF ( 11-6 )
10   -   27
 AFC East
01/09/22
Indianapolis Colts IND ( 9-8 )
Jacksonville Jaguars JAC ( 3-14 )
11   -   26
 AFC South
01/02/22
Las Vegas Raiders LV ( 10-7 )
Indianapolis Colts IND ( 9-8 )
23   -   20
 AFC West
01/02/22
Atlanta Falcons ATL ( 7-10 )
Buffalo Bills BUF ( 11-6 )
15   -   29
 NFC South
12/26/21
Buffalo Bills BUF ( 11-6 )
New England Patriots NE ( 10-7 )
33   -   21
 AFC East
12/25/21
Indianapolis Colts IND ( 9-8 )
Arizona Cardinals ARI ( 11-6 )
22   -   16
 AFC South
12/19/21
Carolina Panthers CAR ( 5-12 )
Buffalo Bills BUF ( 11-6 )
14   -   31
 NFC South
12/18/21
New England Patriots NE ( 10-7 )
Indianapolis Colts IND ( 9-8 )
17   -   27
 AFC East
12/05/21
Indianapolis Colts IND ( 9-8 )
Houston Texans HOU ( 4-13 )
31   -   0
 AFC South
11/28/21
Tampa Bay Buccaneers TB ( 13-4 )
Indianapolis Colts IND ( 9-8 )
38   -   31
 NFC South

Betting Action

Spread Bets • 7.5
Indianapolis Colts IND
60%
Buffalo Bills BUF
40%
Totals (O/U) • 49.5
Over 56%
Under 44%
Money Bets •
Indianapolis Colts IND
0%
Buffalo Bills BUF
0%

Line History

Matchup Details

Indianapolis Colts IND
Buffalo Bills BUF
Stat
5 Games Won 6
5 Games Lost 3
6-4 Last 10 6-4
0-0 W L Streak 0-0
6-4 Against The Spread 5-3
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
6-4 Total 4-5

Recent Meetings

date home-away ats o/u BUF:Total Net Yards BUF:Net Rushing Yards BUF:Passing Yards IND:Total Net Yards IND:Net Rushing Yards IND:Passing Yards
11/10/2024 IND 20 - BUF 30 BUF -4.5 Over 46.5 415 135 280 361 121 240
08/12/2023 BUF 23 - IND 19 BUF +2.5 Over 38 289 96 193 348 82 266
08/13/2022 BUF 27 - IND 24 BUF -1 Over 34 288 101 187 369 65 304
11/21/2021 BUF 15 - IND 41 IND +7 Over 49 311 91 220 370 264 106
01/09/2021 BUF 27 - IND 24 IND +6.5 Under 51.5 472 163 309 397 96 301
08/08/2019 BUF 24 - IND 16 BUF +1.5 Over 34.5 314 105 209 381 163 218
10/21/2018 IND 37 - BUF 5 IND -8 Under 43.5 303 135 168 376 220 156
12/10/2017 BUF 13 - IND 7 BUF -3.5 Under 36.5 227 163 64 319 227 92
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/09/2022 JAC 26 - IND 11 L -14 Under 44 233 94 139
01/02/2022 IND 20 - LV 23 L -8.5 Under 47 326 85 241
12/25/2021 ARI 16 - IND 22 W +2 Under 48 346 126 220
12/18/2021 IND 27 - NE 17 W -1.5 Under 46.5 365 81 284
12/05/2021 HOU 0 - IND 31 W -10 Under 46 389 238 151
11/28/2021 IND 31 - TB 38 L +2.5 Over 53 359 142 217
11/21/2021 BUF 15 - IND 41 W +7 Over 49 370 264 106
11/14/2021 IND 23 - JAC 17 L -10.5 Under 48 331 179 152
11/04/2021 IND 45 - NYJ 30 W -10 Over 45 486 88 398
10/31/2021 IND 31 - TEN 34 L +1 Over 47.5 340 93 247
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/23/2022 KC 42 - BUF 36 L +2.5 Over 54 552 182 370
01/15/2022 BUF 47 - NE 17 W -4.5 Over 43.5 482 174 308
01/09/2022 BUF 27 - NYJ 10 W -17 Under 43 424 170 254
01/02/2022 BUF 29 - ATL 15 W -13.5 Under 46.5 351 233 118
12/26/2021 NE 21 - BUF 33 W +1 Over 44.5 288 149 139
12/19/2021 BUF 31 - CAR 14 W -12 Over 43.5 312 119 193
12/12/2021 TB 33 - BUF 27 L +3 Over 53 488 137 351
12/06/2021 BUF 10 - NE 14 L -3 Under 41 230 99 131
11/25/2021 NO 6 - BUF 31 W -7 Under 46.5 190 44 146
11/21/2021 BUF 15 - IND 41 L -7 Over 49 311 91 220

Odds Analysis

Team Rankings

Indianapolis Colts IND
Season stats rank
Total Yards 343.2 16
Passing Yards 234.12 19
Rushing Yards 109.06 10
Points Scored 21.47 10
Field Goal % 0.81 6
Buffalo Bills BUF
Season stats rank
Total Yards 272.8 1
Passing Yards 163 1
Rushing Yards 109.76 13
Points Scored 17 1
Field Goal % 0.91 27
Indianapolis Colts IND
Season stats rank
Total Yards 347.1 16
Passing Yards 197.71 26
Rushing Yards 149.41 2
Points Scored 26.53 9
Field Goal % 0.83 21
Buffalo Bills BUF
Season stats rank
Total Yards 381.9 5
Passing Yards 252 9
Rushing Yards 129.94 6
Points Scored 28.41 3
Field Goal % 0.88 12

Injuries

Indianapolis Colts IND
Buffalo Bills BUF

Indianapolis vs. Buffalo Betting News

Indianapolis Colts IND

No posts found.
Buffalo Bills BUF

No posts found.

Indianapolis Vs Buffalo Betting Trends

Indianapolis Colts IND

Colts are 5-2 ATS in their last 7 games as a favorite of 3.5-10.0.

Colts are 4-0 ATS in their last 4 games following a ATS loss.

Over is 5-2 in Colts last 7 games overall.

Colts are 12-5-1 ATS in their last 18 games as a road favorite of 3.5-10.0.

Colts are 2-5 ATS in their last 7 games as a favorite.

Buffalo Bills BUF

Bills are 12-3-1 ATS in their last 16 games after scoring more than 30 points in their previous game.

Under is 4-1 in Bills last 5 games as an underdog of 10.5 or greater.

Bills are 9-4-1 ATS in their last 14 games as a favorite.

Bills are 7-2-1 ATS in their last 10 home games.

Bills are 11-5 ATS in their last 16 games following a straight up win.

Line Up - Last Game

Indianapolis Colts
Pitchers
POS Player
Hitters
POS Player
Buffalo Bills
Pitchers
POS Player
Hitters
POS Player
  • IND
  • +7.5 -7.5
  • BUF
NFL Odds