Sports Interaction

Cardinals vs. 49ers Prediction, Odds & Stats - September 21, 2025

Final Score
Arizona
Cardinals
San Francisco
49ers
15
16
Arizona Cardinals
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Arizona Cardinals 3-14 0 3 3 9 +44.5
San Francisco 49ers 12-5 0 6 0 10 -1.5

Latest Encounters

Date Result Competition Stats Recap
01/17/26
San Francisco 49ers SF ( 12-5 )
Seattle Seahawks SEA ( 14-3 )
6   -   41
NFC West
01/11/26
San Francisco 49ers SF ( 12-5 )
Philadelphia Eagles PHI ( 11-6 )
23   -   19
NFC West
01/04/26
Arizona Cardinals ARI ( 3-14 )
L.A. Rams Rams LAR ( 12-5 )
20   -   37
NFC West
01/03/26
Seattle Seahawks SEA ( 14-3 )
San Francisco 49ers SF ( 12-5 )
13   -   3
NFC West
12/28/25
Chicago Bears CHI ( 11-6 )
San Francisco 49ers SF ( 12-5 )
38   -   42
NFC North
12/28/25
Arizona Cardinals ARI ( 3-14 )
Cincinnati Bengals CIN ( 6-11 )
14   -   37
NFC West
12/22/25
San Francisco 49ers SF ( 12-5 )
Indianapolis Colts IND ( 8-9 )
48   -   27
NFC West
12/21/25
Atlanta Falcons ATL ( 8-9 )
Arizona Cardinals ARI ( 3-14 )
26   -   19
NFC South
12/14/25
Tennessee Titans TEN ( 3-14 )
San Francisco 49ers SF ( 12-5 )
24   -   37
AFC South
12/14/25
Arizona Cardinals ARI ( 3-14 )
Houston Texans HOU ( 12-5 )
20   -   40
NFC West
12/07/25
L.A. Rams Rams LAR ( 12-5 )
Arizona Cardinals ARI ( 3-14 )
45   -   17
NFC West
11/30/25
Arizona Cardinals ARI ( 3-14 )
Tampa Bay Buccaneers TB ( 8-9 )
17   -   20
NFC West

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Arizona Cardinals Arizona Cardinals
2 0 1-9 9L 1-1 0 0-0 0-0 1-1
San Francisco 49ers San Francisco 49ers
2 0 7-3 1L 2-0 0 0-0 0-0 1-1

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 281 95 186 488 36 452
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 355 73 282 260 106 154
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 LAR 37 - ARI 20 L +14 Over 49 317 79 238
12/28/2025 CIN 37 - ARI 14 L +6.5 Over 50.5 254 42 212
12/21/2025 ARI 19 - ATL 26 L +1.5 Under 48 342 152 190
12/14/2025 HOU 40 - ARI 20 L +7.5 Over 42 307 72 235
12/07/2025 ARI 17 - LAR 45 L +1.5 Over 49 530 249 281
11/30/2025 TB 20 - ARI 17 W +3 Under 45.5 386 95 291
11/23/2025 ARI 24 - JAC 27 L +2.5 Over 47.5 371 134 237
11/16/2025 ARI 22 - SF 41 L +3.5 Over 47.5 281 95 186
11/09/2025 SEA 44 - ARI 22 L +1.5 Over 45.5 335 129 206
11/03/2025 DAL 17 - ARI 27 W +3 Under 52.5 340 119 221
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 SEA 41 - SF 6 L +7 Over 45.5 281 175 106
01/11/2026 PHI 19 - SF 23 W +5.5 Under 46.5 307 140 167
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 173 53 120
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 496 200 296
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 312 58 254
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 430 138 292
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 253 138 115
11/24/2025 SF 20 - CAR 9 W -7 Under 49 340 147 193
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 488 36 452
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 393 74 319

Matchup Edge - Scoring Stats

avg rank edge in rank avg
20.88 22 Points Per Game 9 25.71
28.71 29 Points Allowed Per Game 13 21.82
4.53 15 1st Quarter Scoring Per Game 8 5.59
5.94 22 1st Quarter Scoring Allowed Per Game 9 4.06
6.29 18 2nd Quarter Scoring Per Game 8 7.71
8.82 23 2nd Quarter Scoring Allowed Per Game 14 7.12
4.88 13 3rd Quarter Scording Per Game 9 5.47
5.35 18 3rd Quarter Scoring Allowed Per Game 12 4.29
5.18 24 4th Quarter Scoring Per Game 12 6.76
8.41 24 4th Quarter Scoring Allowed Per Game 14 6.35
54.1 17 Red Zone Efficiency 4 65.2
325.76 18 Total Yards Per Game 7 351.41
8.53 28 Total Yards Per Play 15 10.41
4.33 14 Rushing Yards Per Play 27 3.78
38.18 1 Passing Attempts Per Game 9 33.76
9.26 25 Passing Yards Per Completion 14 10.44
1.71 6 Passing Tds Per Game 4 1.94
25.12 1 Completions Per Game 4 23.41
65.8 11 Completion % 3 69.3
92.7 12 Qb Rating 6 98.76
3.47 3 Defense Sacks Per Game 19 1.59
0.65 10 Defense Interceptions Per Game 5 0.94
1.06 8 Opponent Fumbles Per Game 10 1.18
0.59 4 Opponent Fumbles Lost Per Game 8 0.35
6.76 13 Penalties Per Game 2 4.88
49.53 15 Penalty Yards Per Game 3 38.29
21 9 Takeaway / Giveaway Differential 10 22
3.62 22 Yards Per Punt Return 3 6.61
25.05 25 Yards Per Kickoff Return 7 27.16

Odds Analysis

Team Rankings

offence
Arizona Cardinals ARI
Season stats rank
Total Yards 325.8 19
Passing Yards 232.65 7
Rushing Yards 93.12 31
Points Scored 20.88 23
Field Goal % 0.76 30
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6
defence
Arizona Cardinals ARI
Season stats rank
Total Yards 325.8 19
Passing Yards 232.65 7
Rushing Yards 93.12 31
Points Scored 20.88 23
Field Goal % 0.76 30
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6

Injuries

Arizona Cardinals ARI
San Francisco 49ers SF

NFC West Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player