Sports Interaction

Cardinals vs. 49ers Prediction, Odds & Stats September 21, 2025

Final Score
Arizona
Cardinals
San Francisco
49ers
15
16
Arizona Cardinals
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Arizona Cardinals 3-14 0 3 3 9 +44.5
San Francisco 49ers 12-5 0 6 0 10 -1.5

Latest Encounters

Date Result Competition Stats Recap
01/17/26
San Francisco 49ers SF ( 12-5 )
Seattle Seahawks SEA ( 14-3 )
6   -   41
NFC West
01/11/26
San Francisco 49ers SF ( 12-5 )
Philadelphia Eagles PHI ( 11-6 )
23   -   19
NFC West
01/04/26
Arizona Cardinals ARI ( 3-14 )
L.A. Rams Rams LAR ( 12-5 )
20   -   37
NFC West
01/03/26
Seattle Seahawks SEA ( 14-3 )
San Francisco 49ers SF ( 12-5 )
13   -   3
NFC West
12/28/25
Chicago Bears CHI ( 10-6 )
San Francisco 49ers SF ( 12-5 )
38   -   42
NFC North
12/28/25
Arizona Cardinals ARI ( 3-14 )
Cincinnati Bengals CIN ( 6-11 )
14   -   37
NFC West
12/22/25
San Francisco 49ers SF ( 12-5 )
Indianapolis Colts IND ( 8-9 )
48   -   27
NFC West
12/21/25
Atlanta Falcons ATL ( 8-9 )
Arizona Cardinals ARI ( 3-14 )
26   -   19
NFC South
12/14/25
Tennessee Titans TEN ( 3-14 )
San Francisco 49ers SF ( 12-5 )
24   -   37
AFC South
12/14/25
Arizona Cardinals ARI ( 3-14 )
Houston Texans HOU ( 12-5 )
20   -   40
NFC West
12/07/25
L.A. Rams Rams LAR ( 12-5 )
Arizona Cardinals ARI ( 3-14 )
45   -   17
NFC West
11/30/25
Arizona Cardinals ARI ( 3-14 )
Tampa Bay Buccaneers TB ( 8-9 )
17   -   20
NFC West

Line History

Matchup Details

Stat
2 Games Won 2
0 Games Lost 0
1-9 Last 10 7-3
0-0 W L Streak 0-0
1-1 Against The Spread 2-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
1-1 Total 1-1

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 281 95 186 488 36 452
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 355 73 282 260 106 154
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 LAR 37 - ARI 20 L +14 Over 49 317 79 238
12/28/2025 CIN 37 - ARI 14 L +6.5 Over 50.5 254 42 212
12/21/2025 ARI 19 - ATL 26 L +1.5 Under 48 342 152 190
12/14/2025 HOU 40 - ARI 20 L +7.5 Over 42 307 72 235
12/07/2025 ARI 17 - LAR 45 L +1.5 Over 49 530 249 281
11/30/2025 TB 20 - ARI 17 W +3 Under 45.5 386 95 291
11/23/2025 ARI 24 - JAC 27 L +2.5 Over 47.5 371 134 237
11/16/2025 ARI 22 - SF 41 L +3.5 Over 47.5 281 95 186
11/09/2025 SEA 44 - ARI 22 L +1.5 Over 45.5 335 129 206
11/03/2025 DAL 17 - ARI 27 W +3 Under 52.5 340 119 221
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 SEA 41 - SF 6 L +7 Over 45.5 281 175 106
01/11/2026 PHI 19 - SF 23 W +5.5 Under 46.5 307 140 167
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 173 53 120
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 496 200 296
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 312 58 254
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 430 138 292
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 253 138 115
11/24/2025 SF 20 - CAR 9 W -7 Under 49 340 147 193
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 488 36 452
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 393 74 319

Matchup Edge - Scoring Stats

avg rank edge in rank avg
2.1 1 Qb Rating 1 2.1

Odds Analysis

Team Rankings

Arizona Cardinals ARI
Season stats rank
Total Yards 357.7 28
Passing Yards 230.76 24
Rushing Yards 126.94 25
Points Scored 28.71 29
Field Goal % 0.9 24
San Francisco 49ers SF
Season stats rank
Total Yards 340.2 20
Passing Yards 232.41 25
Rushing Yards 107.82 11
Points Scored 21.82 13
Field Goal % 0.67 1
Arizona Cardinals ARI
Season stats rank
Total Yards 325.8 19
Passing Yards 232.65 7
Rushing Yards 93.12 31
Points Scored 20.88 23
Field Goal % 0.76 30
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 9
Field Goal % 0.92 6

Injuries

Arizona Cardinals ARI
San Francisco 49ers SF

Arizona vs. San Francisco Betting News

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San Francisco 49ers SF

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NFC West Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
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Pitchers
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Hitters
POS Player