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Cardinals vs. 49ers Prediction, Odds & Stats September 21, 2025

Final Score
NFC West
Sep 21st, 4:25 PM EDT
Arizona
Cardinals
San Francisco
49ers
15
16
Arizona Cardinals
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Arizona Cardinals 3-14 0 3 3 9 +44.5
San Francisco 49ers 12-5 0 6 0 10 -1.5
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Latest Encounters

Date Result Competition Stats Recap
01/17/26
San Francisco 49ers SF ( 12-5 )
Seattle Seahawks SEA ( 14-3 )
6   -   41
 NFC West
01/11/26
San Francisco 49ers SF ( 12-5 )
Philadelphia Eagles PHI ( 11-6 )
23   -   19
 NFC West
01/04/26
Arizona Cardinals ARI ( 3-14 )
L.A. Rams Rams LAR ( 12-5 )
20   -   37
 NFC West

Line History

Matchup Details

Arizona Cardinals ARI
San Francisco 49ers SF
Stat
2 Games Won 2
0 Games Lost 0
1-9 Last 10 7-3
0-0 W L Streak 0-0
1-1 Against The Spread 2-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
1-1 Total 1-1

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards ARI:Total Net Yards ARI:Net Rushing Yards ARI:Passing Yards
11/16/2025 ARI 22 - SF 41 SF -3.5 Over 47.5 281 95 186 488 36 452
09/21/2025 SF 16 - ARI 15 SF -3.5 Under 44.5 355 73 282 260 106 154
01/05/2025 ARI 47 - SF 24 ARI -4.5 Over 43.5 436 138 298 393 151 242
10/06/2024 SF 23 - ARI 24 ARI +7.5 Under 48.5 358 169 189 384 153 231
12/17/2023 ARI 29 - SF 45 SF -14 Over 48 406 144 262 436 234 202
10/01/2023 SF 35 - ARI 16 SF -14.5 Over 42 362 105 257 395 124 271
01/08/2023 SF 38 - ARI 13 SF -13.5 Over 39.5 255 61 194 311 169 142
11/21/2022 ARI 10 - SF 38 SF -7.5 Over 43 387 159 228 314 67 247
11/07/2021 SF 17 - ARI 31 ARI +5.5 Over 46.5 437 163 274 337 39 298
10/10/2021 ARI 17 - SF 10 ARI -4.5 Under 53.5 338 152 186 304 94 210
12/26/2020 ARI 12 - SF 20 SF +4 Under 49 398 227 171 350 120 230
09/13/2020 SF 20 - ARI 24 ARI +7.5 Under 47 404 180 224 366 123 243
11/17/2019 SF 36 - ARI 26 SF -11.5 Over 44 266 135 131 442 34 408
10/31/2019 ARI 25 - SF 28 ARI +8 Over 43.5 411 101 310 357 153 204
10/28/2018 ARI 18 - SF 15 ARI 0 Under 40 267 107 160 321 88 233
10/07/2018 SF 18 - ARI 28 ARI +5 Over 40.5 220 56 164 447 147 300
11/05/2017 SF 10 - ARI 20 ARI -2.5 Under 39 368 167 201 329 63 266
10/01/2017 ARI 18 - SF 15 ARI -7 Under 43 305 95 210 368 51 317
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/04/2026 LAR 37 - ARI 20 L +14 Over 49 317 79 238
12/28/2025 CIN 37 - ARI 14 L +6.5 Over 50.5 254 42 212
12/21/2025 ARI 19 - ATL 26 L +1.5 Under 48 342 152 190
12/14/2025 HOU 40 - ARI 20 L +7.5 Over 42 307 72 235
12/07/2025 ARI 17 - LAR 45 L +1.5 Over 49 530 249 281
11/30/2025 TB 20 - ARI 17 W +3 Under 45.5 386 95 291
11/23/2025 ARI 24 - JAC 27 L +2.5 Over 47.5 371 134 237
11/16/2025 ARI 22 - SF 41 L +3.5 Over 47.5 281 95 186
11/09/2025 SEA 44 - ARI 22 L +1.5 Over 45.5 335 129 206
11/03/2025 DAL 17 - ARI 27 W +3 Under 52.5 340 119 221
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 SEA 41 - SF 6 L +7 Over 45.5 281 175 106
01/11/2026 PHI 19 - SF 23 W +5.5 Under 46.5 307 140 167
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 173 53 120
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 496 200 296
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 312 58 254
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 430 138 292
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 253 138 115
11/24/2025 SF 20 - CAR 9 W -7 Under 49 340 147 193
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 488 36 452
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 393 74 319

Odds Analysis

Team Rankings

Arizona Cardinals ARI
Season stats rank
Total Yards 357.7 28
Passing Yards 230.76 24
Rushing Yards 126.94 25
Points Scored 28.71 29
Field Goal % 0.9 24
San Francisco 49ers SF
Season stats rank
Total Yards 340.2 20
Passing Yards 232.41 25
Rushing Yards 107.82 11
Points Scored 21.82 13
Field Goal % 0.67 1
Arizona Cardinals ARI
Season stats rank
Total Yards 325.8 19
Passing Yards 232.65 7
Rushing Yards 93.12 31
Points Scored 20.88 23
Field Goal % 0.76 30
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 9
Field Goal % 0.92 6

Injuries

Arizona Cardinals ARI
San Francisco 49ers SF

Arizona vs. San Francisco Betting News

Arizona Cardinals ARI

No posts found.
San Francisco 49ers SF

No posts found.

Arizona Vs San Francisco Betting Trends

Arizona Cardinals ARI

Over is 4-0 in Cardinals last 4 games after allowing more than 350 total yards in their previous game.

Cardinals are 19-4-3 ATS in their last 26 games as a road underdog of 3.5-10.0.

Over is 5-1 in Cardinals last 6 games as a favorite.

Under is 4-1 in Cardinals last 5 games in Week 3.

Cardinals are 6-1 ATS in their last 7 games as a road underdog.

San Francisco 49ers SF

49ers are 4-12 ATS in their last 16 home games.

49ers are 4-1 ATS in their last 5 games as a home underdog of 0.5-3.0.

49ers are 2-8 ATS in their last 10 games following a ATS win.

Over is 7-3 in 49ers last 10 games in Week 3.

49ers are 2-6 ATS in their last 8 games as a home favorite of 3.5-10.0.

NFC West Standings

Line Up - Last Game

Arizona Cardinals
Pitchers
POS Player
Hitters
POS Player
San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player
  • ARI
  • +1.5 -1.5
  • SF
NFL Odds