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Broncos vs. 49ers Prediction, Odds & Stats October 04, 2026

Game Scheduled
AFC West
Oct 4th, 4:25 PM EDT
Denver
Broncos
W W L W L
San Francisco
49ers
W W W W L
VS
Denver Broncos
San Francisco 49ers
Scoreboard Spread Moneyline O/U
Denver Broncos 2-1 - - -
San Francisco 49ers 3-0 - - -
Loading odds...

Latest Encounters

Date Result Competition Stats Recap
09/27/26
L.A. Rams Rams LAR ( 1-2 )
Denver Broncos DEN ( 2-1 )
26   -   30
 NFC West
09/27/26
Arizona Cardinals ARI ( 1-2 )
San Francisco 49ers SF ( 3-0 )
30   -   36
 NFC West
09/20/26
Miami Dolphins MIA ( 0-3 )
San Francisco 49ers SF ( 3-0 )
13   -   35
 AFC East

Line History

Matchup Details

Denver Broncos DEN
San Francisco 49ers SF
Stat
2 Games Won 3
1 Games Lost 0
2-1 Last 10 3-0
0-0 W L Streak 0-0
2-1 Against The Spread 2-1
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
1-2 Total 2-1

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards DEN:Total Net Yards DEN:Net Rushing Yards DEN:Passing Yards
08/09/2025 SF 9 - DEN 30 DEN +1.5 Over 38 368 153 215 203 96 107
08/19/2023 SF 21 - DEN 20 SF +3.5 Over 37 322 165 157 422 99 323
09/25/2022 DEN 11 - SF 10 DEN -2.5 Under 45 267 88 179 261 101 160
08/19/2019 DEN 15 - SF 24 SF +2.5 Under 40 278 185 93 215 113 102
12/09/2018 SF 20 - DEN 14 SF +3 Under 44 274 103 171 389 84 305
08/19/2017 SF 14 - DEN 33 DEN +1 Over 40 315 146 169 243 37 206
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
09/27/2026 DEN 30 - LAR 26 W +2.5 Over 45.5 482 116 366
09/20/2026 DEN 20 - JAC 13 W -3 Under 44.5 268 95 173
09/14/2026 KC 31 - DEN 10 L +2.5 Under 42.5 176 61 115
08/28/2026 DEN 34 - MIN 6 W -4.5 Over 37.5 269 89 180
08/21/2026 DEN 13 - GB 33 L -3.5 Over 39 299 118 181
08/14/2026 ATL 7 - DEN 27 W -5.5 Under 38 359 162 197
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
09/27/2026 SF 36 - ARI 30 L -8.5 Over 48 437 140 297
09/20/2026 SF 35 - MIA 13 W -10.5 Over 46 382 95 287
09/10/2026 LAR 7 - SF 27 W +2.5 Under 48.5 290 122 168
08/27/2026 LV 12 - SF 18 W +1 Under 38.5 251 113 138
08/20/2026 LAC 17 - SF 41 W +1 Over 39.5 229 68 161
08/13/2026 SF 13 - TEN 19 L +2 Under 38.5 322 84 238

Odds Analysis

Team Rankings

Denver Broncos DEN
Season stats rank
Total Yards 380.7 29
Passing Yards 237 25
Rushing Yards 143.67 30
Points Scored 23.33 17
Field Goal % 0.88 19
San Francisco 49ers SF
Season stats rank
Total Yards 313 9
Passing Yards 207.33 15
Rushing Yards 105.67 15
Points Scored 16.67 3
Field Goal % 0.83 14
Denver Broncos DEN
Season stats rank
Total Yards 275 28
Passing Yards 194 22
Rushing Yards 81 31
Points Scored 20 21
Field Goal % 0.75 24
San Francisco 49ers SF
Season stats rank
Total Yards 399.3 5
Passing Yards 263 7
Rushing Yards 136.33 6
Points Scored 32.67 2
Field Goal % 0.75 22

Injuries

Denver Broncos DEN
San Francisco 49ers SF

Denver vs. San Francisco Betting News

Denver Broncos DEN

No posts found.
San Francisco 49ers SF

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Denver Vs San Francisco Betting Trends

Denver Broncos DEN

Broncos are 5-2 ATS in their last 7 games as a road underdog of 3.5-10.0.

Broncos are 2-5 ATS in their last 7 games as a road underdog.

Under is 4-1 in Broncos last 5 games as a favorite of 10.5 or greater.

Broncos are 0-4 ATS in their last 4 road games.

Under is 5-1 in Broncos last 6 games as a road underdog of 3.5-10.0.

San Francisco 49ers SF

Over is 4-1 in 49ers last 5 games as a home underdog of 3.5-10.0.

49ers are 8-17-1 ATS in their last 26 home games.

Over is 6-1 in 49ers last 7 games after allowing more than 350 total yards in their previous game.

49ers are 10-4-1 ATS in their last 15 games as a home underdog of 0.5-3.0.

Over is 5-0 in 49ers last 5 games as a favorite.

American Football Conference Standings

National Football Conference Standings

Line Up - Last Game

Denver Broncos
Pitchers
POS Player
Hitters
POS Player
San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player