Boston Red Sox vs. Toronto Blue Jays: Odds, Prediction

Payton Matthews | Updated Apr 25, 2022

Vlad Guerrerrro Jr., Blue Jays, 2022

After taking two of three games in Boston last week, the Blue Jays open up a 4-game set against the Red Sox in Toronto starting Monday night.

April 25, 2022, 7:07 PM ET
Rogers Centre
Runline +1.5 -177
Moneyline +112
Over / Under o +8


Betting Action


Runline -1.5 +147
Moneyline -134
Over / Under u +8


Betting Action


The Boston Red Sox make their first visit of the season to Toronto starting Monday, and the Red Sox will be down at least a few unvaccinated players. The Jays are -140 favourites on the MLB odds.

Betting Analysis

These clubs played last week in Boston and after losing the opener 2-1, the Blue Jays won the next two despite not having starting catcher Danny Jansen or DH Teoscar Hernandez for the series. Both remain on the injured list. Alejandro Kirk was 4-for-7 with a run scored in his two games. Matt Chapman was 5-for-13 with a double. Vladimir Guerrero Jr. was 3-for-8 and was walked four times. Zack Collins and Raimel Tapia had the only Blue Jays homers in the series.

Boston scored five total runs and hit .219 in the series. Designated hitter JD Martinez was limited to two games and top catcher Christian Vazquez to one. Xander Bogaerts had a nice series, going 5-for-12 with two doubles. All-Star third baseman Rafael Devers was 1-for-12.

The Red Sox won five of nine games as the road team against the Jays last year. The total has gone under in five of the past six meetings.

Boston Red Sox

The Jays are going to catch breaks all season in that unvaccinated players on opposing teams can’t travel to Canada, and the Red Sox have at least a few it has been reported. The one we know for sure is starting pitcher Tanner Houck. He took the loss Thursday vs. Toronto, allowing two runs over five innings. Manager Alex Cora is vaccinated but tested positive last week and has been experiencing mild symptoms so he presumably won’t make the trip. Bench coach Will Venable has been running the club in his absence. Catchers Christian Vazquez and Kevin Plawecki and infielder Jonathan Arauz were all placed on the COVID-19 injured list last week, but Vazquez has since returned. DH JD Martinez didn’t play over the weekend at the Rays due to a groin injury so his status is unclear. Ace Nathan Eovaldi (1-0, 3.68 ERA) is on the mound Monday. He allowed one run and seven hits over 4.2 innings last Tuesday vs. the Jays in a no-decision. Bo Bichette is 5-for-15 off him with a homer. Cavan Biggio 2-for-7 with two solo shots. Boston is 8-18 in its past 26 as a road dog.

Toronto Blue Jays

Not clear if closer Jordan Romano will be available after blowing a save Sunday and taking the loss a 10-inning defeat in Houston. He had converted 31 straight saves, the longest streak in the majors. This starts a very challenging 10-game homestand against AL contenders in the Red Sox, Astros and Yankees. Jose Berrios (1-0, 6.35) takes the mound in Monday’s opener. The right-hander was not great in his first two outings but solid last Wednesday in winning in Boston, allowing one run and eight hits with six strikeouts and one walk over six. That start could have gone south quickly with Boston up 1-0 in the bottom of the first and two on with two out, but Berrios struck out Trevor Story to end the inning.

JD Martinez has had career success off Berrios, going 7-for-20 with two doubles and five RBIs – he had an RBI single in the bottom of the first last Wednesday. Rafael Devers is 4-for-17 with three doubles and a homer. Xander Bogaerts just 3-for-20 with seven Ks. Toronto is 7-2 in its past nine as a home favourite.

Who Will Win Red Sox vs. Blue Jays?