Vikings vs. 49ers Point Spread: NFL Week 12 Odds, Prediction

Nik Kowalski | Updated Nov 25, 2021

A pair of 5-5 clubs in the San Francisco 49ers and Minnesota Vikings square off out West in a contest with playoff implications in the NFC.

November 28, 2021, 4:25 PM ET
Levi's Stadium
Pointspread +4 -110
Moneyline +168
Over / Under o +49.5


Betting Action


Pointspread -4 -110
Moneyline -202
Over / Under u +49.5


Betting Action


Both teams are entering Sunday with some momentum. The Vikings are winners of two straight, most recently defeating division rival Green Bay 34-31. The 49ers have also earned two straight dubs, the first of their current streak also coming against a division rival in the Rams.

Kickoff at Levi’s Stadium starts at 4:25 p.m. EST. The 49ers are 3-point favourites to win at home, with the over-under at 48.5 on the NFL odds.

NFL Point Spread and Betting Analysis

Home field has not treated San Francisco well in 2021. The 49ers are both 1-4 overall and against the spread when at Levi’s Stadium this season, while Minnesota’s been able to cover in four of their five road games. The over is also 4-1 in the Vikings’ five road games in 2021. In fact, Minnesota is scoring 29 points per game on the road this season and 21 when at home.

All said and done, Minnesota just might be what the doctor ordered for the struggling home 49ers. In their last 11 meetings in California, San Francisco is 10-1 straight up.

Minnesota Vikings

After an overturned interception, Kirk Cousins came through in the clutch for Minnesota with another two-minute drill to beat the Packers. Overall Cousins finished with 341 passing yards, three touchdowns, and zero interceptions. Cousins now has a sneaky 21:2 touchdown to interception ratio this season.

To little surprise, Cousins leaned on star receivers Justin Jefferson and Adam Thielen in the win. Jefferson recorded a game-high 169 yards and had two scores on eight catches while Thielen hauled in eight receptions for 82 yards and a touchdown.

Vikings defensive end Everson Griffen will likely be out of the lineup for the foreseeable future after an off-field incident.

San Francisco 49ers

The 49ers waxed the Jaguars last week in an outing that saw San Francisco allow 200 yards of offence. They now rank sixth in the NFL with 318.3 yards against per game. San Francisco pounded the ball for 171 rushing yards on 42 carries in the win. They were led by receiver Deebo Samuel on the ground as he had eight carries for 79 yards and a score.

Running backs Elijah Mitchell and JaMycal Hasty both missed practice Wednesday which puts Jeff Wilson Jr. in line for another start. Defensive end Dee Ford, who has three sacks in six games this season, has been activated off the injured reserve list and may suit up Sunday.

NFL Prediction: Who Will Win Vikings vs. 49ers?