There are big spreads – and then there’s the massive odds chasm between the Houston Texans and Arizona Cardinals, who square off Sunday afternoon in Glendale. The Cardinals are favoured by more than two touchdowns as they look to remain the lone unbeaten team in the NFL – and those looking for massive payday in Week 7 action might consider an outright play on the underdog Texans, though that’s a bold call given their road struggles in 2021.

NFL Point Spread and Betting Analysis

This is easily the biggest spread of the NFL season to date – and the most points the Cardinals have been favoured in franchise history. And despite the massive gap, 62 percent of the Sports Interaction betting public is siding with the unbeaten hosts. You have to lower the spread to seven or more points to get a recent sample relevant to this team – and Arizona has gone a perfect 3-0 SU and ATS in three games at -7 or better since 2020.

The totals trends are nearly identical, with 61 percent of SIA bettors siding with the O47.5 at -110. The Cardinals have converted the Under in all three games they’ve played as a fave of 7+ points, but have been a much stronger Over play overall, having gone 6-2 ATS in their last eight games at State Farm Stadium. Houston has gone below the total in two of three road games this season – and I’ll get into why in the very next section.

Houston Texans

The Texans have played the charitable visitors to near-perfection so far this season, giving other teams’ home fans plenty of reason to celebrate. Houston comes into Week 7 having not only lost all three games away from NRG Stadium, they’ve been outscored by a ridiculous 102-24 margin – including a 71-3 gap in consecutive losses at Buffalo and Indianapolis. Houston has dropped five straight road games dating back to 2020.

Arizona Cardinals

Looking for value outside of the spread or total? It’s a bit tougher when one team is favoured by so much – but there are potential value pockets here. Arizona is averaging 7.5 first-quarter points per game, second-most in the NFL behind only Dallas. Houston, on the other hand, is allowing 7.0 first-quarter points per contest on the road. Bettors might want to consider loading up on the “Quarter of First Touchdown: 1st” prop, which pays -345.

Who Will Win Texans vs. Cardinals?

• Regular Season

Texans Team Leaders

HOU

Touchdowns	Brandin Cooks 3
Rushing	David Johnson 176
Passing	Davis Mills 1406
Receiving	Brandin Cooks 65
Sacks	Jonathan Greenard 8
Interceptions	Lonnie Johnson Jr. 3

ARI

Touchdowns	James Conner 14
Rushing	James Conner 630
Passing	Kyler Murray 2399
Receiving	Christian Kirk 50
Sacks	Markus Golden 10
Interceptions	Byron Murphy Jr. 4

• Regular Season

Cardinals Team Leaders

HOU

Touchdowns	Brandin Cooks 3
Rushing	David Johnson 176
Passing	Davis Mills 1406
Receiving	Brandin Cooks 65
Sacks	Jonathan Greenard 8
Interceptions	Lonnie Johnson Jr. 3

ARI

Touchdowns	James Conner 14
Rushing	James Conner 630
Passing	Kyler Murray 2399
Receiving	Christian Kirk 50
Sacks	Markus Golden 10
Interceptions	Byron Murphy Jr. 4

Weather

condition

dome

Injuries

Houston

Tyrod Taylor (QB)

Ques Sun Wrist - 05 / 12 / 21

Terrance Mitchell (DB)

Prob Sun Illness - 03 / 12 / 21

Roy Lopez (DL)

Ques Sun Illness - 03 / 12 / 21

Chris Conley (WR)

Ques Sun Illness - 01 / 12 / 21

Brandin Cooks (WR)

Prob Sun Illness - 01 / 12 / 21

Jonathan Greenard (DL)

Ques Sun Foot - 01 / 12 / 21

David Johnson (RB)

Ques Sun Illness - 01 / 12 / 21

Jacob Martin (DL)

Prob Sun Shin - 01 / 12 / 21

Justin McCray (OL)

Ques Sun Concussion - 01 / 12 / 21

Cole Toner (OL)

Ques Sun Illness - 01 / 12 / 21

Arizona

Byron Murphy Jr. (CB)

Ques Sun Foot - 03 / 12 / 21

Max Garcia (OL)

Prob Sun Knee - 01 / 12 / 21

Greg Mabin (CB)

Ques Sun Ankle - 24 / 11 / 21

Tanner Vallejo (LB)

Out indefinitely Knee - 19 / 11 / 21

Corey Peters (NT)

Ques Sun Shoulder - 19 / 11 / 21

Budda Baker (S)

Ques Sun Heel - 18 / 11 / 21

Darrell Daniels (TE)

Ques Sun Shoulder - 18 / 11 / 21

Michael Dogbe (DE)

Ques Sun Knee - 18 / 11 / 21

Jordan Phillips (DE)

Ques Sun Groin - 18 / 11 / 21

Eno Benjamin (RB)

Prob Sun Groin - 17 / 11 / 21

Injuries

Houston

player (position)	status		ats*current	o/u*	notes
Tyrod Taylor (QB)	Ques Sun	Wrist - 05 / 12 / 21	0-2	0-2	+ -
Taylor was removed from the previous contest with a hyperextended wrist and possible torn ligaments, leaving his status for Sunday versus the Seahawks up in the air.
Terrance Mitchell (DB)	Prob Sun	Illness - 03 / 12 / 21	0-2	0-2	+ -
Mitchell is expected to take on the Colts on Sunday despite an illness.
Roy Lopez (DL)	Ques Sun	Illness - 03 / 12 / 21	0-2	0-2	+ -
Lopez is bothered by an illness, leaving his status versus the Colts on Sunday hazy.
Chris Conley (WR)	Ques Sun	Illness - 01 / 12 / 21	0-2	0-2	+ -
Conley is ailing from an illness, and it is unclear if he will be available on Sunday versus the Colts.
Brandin Cooks (WR)	Prob Sun	Illness - 01 / 12 / 21	0-2	0-2	+ -
Cooks is ailing from an illness, and his status for Sunday's showdown against the Colts is probable.
Jonathan Greenard (DL)	Ques Sun	Foot - 01 / 12 / 21	0-2	0-2	+ -
Greenard is dealing with a foot injury, and it has yet to be decided if he will battle the Colts on Sunday.
David Johnson (RB)	Ques Sun	Illness - 01 / 12 / 21	0-2	0-2	+ -
Johnson sat out the last game with an illness and a thigh injury. It remains to be seen if he will take the field Sunday versus the Seahawks.
Jacob Martin (DL)	Prob Sun	Shin - 01 / 12 / 21	0-2	0-2	+ -
Martin is hobbled by a shin injury, but it is likely that he will partake in Sunday's showdown against the Colts.
Justin McCray (OL)	Ques Sun	Concussion - 01 / 12 / 21	0-2	0-2	+ -
McCray was held out of the previous game due to a concussion, and it is uncertain if he will line up on Sunday versus the Seahawks.
Cole Toner (OL)	Ques Sun	Illness - 01 / 12 / 21	0-2	0-2	+ -
Toner is bothered by an illness, and it has yet to be established if he will be in Sunday's contest against the Colts.

Arizona

player (position)	status		ats*current	o/u*	notes
Byron Murphy Jr. (CB)	Ques Sun	Foot - 03 / 12 / 21	2-0	1-1	+ -
Murphy Jr. is tending to a foot injury, and it is up in the air if he will line up against the Bears on Sunday.
Max Garcia (OL)	Prob Sun	Knee - 01 / 12 / 21	2-0	1-1	+ -
Garcia has a knee injury, but he is likely to be active on Sunday versus the Bears.
Greg Mabin (CB)	Ques Sun	Ankle - 24 / 11 / 21	2-0	1-1	+ -
Mabin missed the last contest with an ankle issue, and it is undecided if he will participate in Sunday's matchup with the Jaguars.
Tanner Vallejo (LB)	Out indefinitely	Knee - 19 / 11 / 21	2-1	2-1	+ -
Vallejo has been shifted to the injured reserve list with a knee injury, and it is unclear when he will return to the lineup.
Corey Peters (NT)	Ques Sun	Shoulder - 19 / 11 / 21	2-1	2-1	+ -
Peters is battling a shoulder injury, and it is up in the air if he will play against the Seahawks on Sunday.
Budda Baker (S)	Ques Sun	Heel - 18 / 11 / 21	2-1	2-1	+ -
Baker is hampered by a heel injury, and it is undetermined if he will take part in Sunday's battle with the Seahawks.
Darrell Daniels (TE)	Ques Sun	Shoulder - 18 / 11 / 21	2-1	2-1	+ -
Daniels is tending to a shoulder issue, and it is unclear if he will play against the Seahawks on Sunday.
Michael Dogbe (DE)	Ques Sun	Knee - 18 / 11 / 21	2-1	2-1	+ -
Dogbe has a knee injury, and it is unknown if he will line up against the Seahawks on Sunday.
Jordan Phillips (DE)	Ques Sun	Groin - 18 / 11 / 21	2-1	2-1	+ -
Phillips is battling a groin injury, and it is undecided if he will be a participant in Sunday's contest against the Seahawks.
Eno Benjamin (RB)	Prob Sun	Groin - 17 / 11 / 21	2-1	2-1	+ -
Benjamin is tending to a groin issue, but it is not likely to affect his availability against the Seahawks on Sunday.