There are big spreads – and then there’s the massive odds chasm between the Houston Texans and Arizona Cardinals, who square off Sunday afternoon in Glendale. The Cardinals are favoured by more than two touchdowns as they look to remain the lone unbeaten team in the NFL – and those looking for massive payday in Week 7 action might consider an outright play on the underdog Texans, though that’s a bold call given their road struggles in 2021.

NFL Point Spread and Betting Analysis

This is easily the biggest spread of the NFL season to date – and the most points the Cardinals have been favoured in franchise history. And despite the massive gap, 62 percent of the Sports Interaction betting public is siding with the unbeaten hosts. You have to lower the spread to seven or more points to get a recent sample relevant to this team – and Arizona has gone a perfect 3-0 SU and ATS in three games at -7 or better since 2020.

The totals trends are nearly identical, with 61 percent of SIA bettors siding with the O47.5 at -110. The Cardinals have converted the Under in all three games they’ve played as a fave of 7+ points, but have been a much stronger Over play overall, having gone 6-2 ATS in their last eight games at State Farm Stadium. Houston has gone below the total in two of three road games this season – and I’ll get into why in the very next section.

Houston Texans

The Texans have played the charitable visitors to near-perfection so far this season, giving other teams’ home fans plenty of reason to celebrate. Houston comes into Week 7 having not only lost all three games away from NRG Stadium, they’ve been outscored by a ridiculous 102-24 margin – including a 71-3 gap in consecutive losses at Buffalo and Indianapolis. Houston has dropped five straight road games dating back to 2020.

Arizona Cardinals

Looking for value outside of the spread or total? It’s a bit tougher when one team is favoured by so much – but there are potential value pockets here. Arizona is averaging 7.5 first-quarter points per game, second-most in the NFL behind only Dallas. Houston, on the other hand, is allowing 7.0 first-quarter points per contest on the road. Bettors might want to consider loading up on the “Quarter of First Touchdown: 1st” prop, which pays -345.

Who Will Win Texans vs. Cardinals?

• Regular Season
• Playoffs

Texans Team Leaders

HOU

Touchdowns	Brandin Cooks 6
Rushing	Rex Burkhead 427
Passing	Davis Mills 2664
Receiving	Brandin Cooks 90
Sacks	Jonathan Greenard 8
Interceptions	Desmond King II 3

ARI

Touchdowns	James Conner 18
Rushing	James Conner 752
Passing	Kyler Murray 3787
Receiving	Christian Kirk 77
Sacks	Markus Golden 11
Interceptions	Byron Murphy Jr. 4

HOU

Touchdowns
Rushing
Passing	Did not qualify
Receiving
Sacks
Interceptions

ARI

Touchdowns	James Conner 1
Rushing	Chase Edmonds 28
Passing	Kyler Murray 137
Receiving	Christian Kirk 6
Sacks	Markus Golden 1
Interceptions	Zach Allen 0

• Regular Season
• Playoffs

Cardinals Team Leaders

HOU

Touchdowns	Brandin Cooks 6
Rushing	Rex Burkhead 427
Passing	Davis Mills 2664
Receiving	Brandin Cooks 90
Sacks	Jonathan Greenard 8
Interceptions	Desmond King II 3

ARI

Touchdowns	James Conner 18
Rushing	James Conner 752
Passing	Kyler Murray 3787
Receiving	Christian Kirk 77
Sacks	Markus Golden 11
Interceptions	Byron Murphy Jr. 4

HOU

Touchdowns
Rushing
Passing	Did not qualify
Receiving
Sacks
Interceptions

ARI

Touchdowns	James Conner 1
Rushing	Chase Edmonds 28
Passing	Kyler Murray 137
Receiving	Christian Kirk 6
Sacks	Markus Golden 1
Interceptions	Zach Allen 0

Weather

condition

dome

Injuries

Houston

Jordan Akins (TE)

Out Sun Illness - 06 / 01 / 22

Chris Conley (WR)

Out Sun Knee - 05 / 01 / 22

Kamu Grugier-Hill (LB)

Prob Sun Knee - 05 / 01 / 22

Justin Britt (OL)

Prob Sun Knee - 05 / 01 / 22

Jonathan Greenard (DL)

day-to-day Foot - 03 / 01 / 22

Jonathan Owens (DB)

I-R Wrist - 03 / 01 / 22

Justin Reid (DB)

Out indefinitely Ankle - 03 / 01 / 22

Grayland Arnold (DB)

I-R Ankle - 03 / 01 / 22

Kevin Pierre-Louis (LB)

Out indefinitely Illness - 31 / 12 / 21

Antony Auclair (TE)

Out indefinitely Illness - 30 / 12 / 21

Arizona

Greg Mabin (CB)

Out indefinitely Illness - 19 / 01 / 22

Zach Allen (DE)

Prob Mon Ankle - 14 / 01 / 22

Justin Pugh (OL)

Ques Mon Calf - 14 / 01 / 22

Isaiah Simmons (LB)

Ques Mon Personal - 14 / 01 / 22

Antonio Hamilton (CB)

Prob Mon Teeth - 14 / 01 / 22

Jonathan Ward (RB)

Ques Mon Knee - 12 / 01 / 22

Zach Allen (DE)

Ques Sun Ankle - 06 / 01 / 22

Chase Edmonds (RB)

Prob Mon Ribs - 06 / 01 / 22

Dennis Gardeck (LB)

Ques Sun Thumb - 06 / 01 / 22

Tanner Vallejo (LB)

Out indefinitely Illness - 04 / 01 / 22

Injuries

Houston

player (position)	status		ats*current	o/u*	notes
Jordan Akins (TE)	Out Sun	Illness - 06 / 01 / 22	0-1	0-1	+ -
Akins is nursing an illness, and he will not be active for Sunday's matchup with the Titans.
Chris Conley (WR)	Out Sun	Knee - 05 / 01 / 22	0-1	0-1	+ -
Conley is nursing a knee issue, and he will not partake in Sunday's matchup with the Titans.
Kamu Grugier-Hill (LB)	Prob Sun	Knee - 05 / 01 / 22	0-1	0-1	+ -
Grigier-Hill has a knee injury, but it is anticipated that he will partake in Sunday's showdown with the Titans.
Justin Britt (OL)	Prob Sun	Knee - 05 / 01 / 22	0-1	0-1	+ -
Britt has a knee injury, but it is projected that he will lace up against the Titans on Sunday.
Jonathan Greenard (DL)	day-to-day	Foot - 03 / 01 / 22	0-1	0-1	+ -
Greenard exited Sunday's tilt against the Titans with a foot injury, and he will not return.
Jonathan Owens (DB)	I-R	Wrist - 03 / 01 / 22	0-1	0-1	+ -
Owens has ended up on the injured reserve list due to a wrist injury.
Justin Reid (DB)	Out indefinitely	Ankle - 03 / 01 / 22	0-1	0-1	+ -
Reid is dealing with injuries to his ankle and knee. He has also been assigned to the IR/COVID-19 list, and it has yet to be established when he will be available.
Grayland Arnold (DB)	I-R	Ankle - 03 / 01 / 22	0-1	0-1	+ -
Arnold has landed on the injured reserve list with an ankle injury.
Kevin Pierre-Louis (LB)	Out indefinitely	Illness - 31 / 12 / 21	1-1	1-1	+ -
Pierre-Louis has been shifted to the IR/COVID-19 list, and it is unknown when he will return.
Antony Auclair (TE)	Out indefinitely	Illness - 30 / 12 / 21	1-1	1-1	+ -
Auclair has been assigned to the IR/COVID-19 list, and it is unclear when he will return.

Arizona

player (position)	status		ats*current	o/u*	notes
Greg Mabin (CB)	Out indefinitely	Illness - 19 / 01 / 22	0-0	0-0	+ -
Mabin has been added to the IR/COVID-19 list, and there is no timetable for return.
Zach Allen (DE)	Prob Mon	Ankle - 14 / 01 / 22	0-1	1-0	+ -
Allen has an ankle injury, but it is projected that he will take on the Rams in the NFC wild-card game.
Justin Pugh (OL)	Ques Mon	Calf - 14 / 01 / 22	0-1	1-0	+ -
Pugh is hobbled by a calf ailment, and it is undetermined if he will line up for the NFC wild-card game versus the Rams.
Isaiah Simmons (LB)	Ques Mon	Personal - 14 / 01 / 22	0-1	1-0	+ -
Simmons is tending to a personal matter, and it is unclear if he will be active for the NFC wild-card battle against the Rams.
Antonio Hamilton (CB)	Prob Mon	Teeth - 14 / 01 / 22	0-1	1-0	+ -
Hamilton is battling a tooth issue, but it is anticipated that he will face the Rams in the NFC wild-card game.
Jonathan Ward (RB)	Ques Mon	Knee - 12 / 01 / 22	0-1	1-0	+ -
Ward is managing a knee injury, and it is undecided if he will suit up for the NFC wild-card game against the Rams.
Zach Allen (DE)	Ques Sun	Ankle - 06 / 01 / 22	1-1	1-1	+ -
Allen is bothered by an ankle injury, and it is uncertain if he will take on the Seahawks on Sunday.
Chase Edmonds (RB)	Prob Mon	Ribs - 06 / 01 / 22	1-1	1-1	+ -
Edmonds has injuries to his ribs and toe, but it is anticipated that he will take the field against the Rams for the NFC wild-card game.
Dennis Gardeck (LB)	Ques Sun	Thumb - 06 / 01 / 22	1-1	1-1	+ -
Gardeck is hindered by a thumb injury, and it is unclear if he will partake in Sunday's contest against the Seahawks.
Tanner Vallejo (LB)	Out indefinitely	Illness - 04 / 01 / 22	1-1	1-1	+ -
Vallejo has been added to the IR/COVID-19 list, and it has yet to be decided when he will return to action.