Seahawks vs. Steelers Point Spread: NFL Week 6 Odds, Prediction

Payton Matthews | Updated Oct 12, 2021

The Steelers and Seahawks will face off Sunday night in Pittsburgh, with both teams missing key players.

October 17, 2021, 8:20 PM ET
Heinz Field
Pointspread +6 +100
Moneyline +220
Over / Under o +43.5


Betting Action


Pointspread -6 -120
Moneyline -265
Over / Under u +43.5


Betting Action


A very impressive consecutive-starts streak for Seattle quarterback Russell Wilson will come to an end on Sunday night in NFL Week 6 as the Seahawks visit the Steelers. Pittsburgh is a 5-point favourite to win on the NFL odds, with a total of 42.5.

NFL Point Spread and Betting Analysis

On paper, back when the NFL schedule was released, it looked like fans were going to get another tremendous matchup on Sunday night in Week 6 (the prime-time games overall have been great all year) between Seattle and Pittsburgh, but both clubs have disappointed at 2-3 and sit last in their respective division. The loser Sunday can probably forget about the playoffs. It’s a break for the Seahawks that it’s a night game and not a 10 a.m. Pacific time kickoff.

Seattle leads the all-time series 10-9, which included a loss in Super Bowl XL following the 2005 season. That was just the second season in the NFL for Steelers future Hall of Fame quarterback Ben Roethlisberger and this most likely will be his last. Roethlisberger struggled mightily in that Super Bowl win, but the Pittsburgh defence dominated.

The last regular season meeting was in 2019, also in Pittsburgh – this was the added 17th opponent for both – and the Seahawks won 28-26 behind Russell Wilson, who was 29-for-35 for 300 yards and three scores. Alas, Wilson will not play in this one. Roethlisberger was knocked out early with an injury that would prove to be season-ending. Backup Mason Rudolph played pretty well in his place, but the only way Rudolph should see the field Sunday is if Big Ben gets hurt again.

The favourite is 5-1 ATS in the past six meetings.

Seattle Seahawks

Future Hall of Fame quarterback Russell Wilson has made 149 straight starts for Seattle, the second-longest streak in league history to begin a career since the AFL-NFL merger, but Wilson will be out until at least Week 10 with a finger injury suffered in a 26-17 home loss to the LA Rams on Thursday in Week 5. Wilson had surgery over the weekend. Veteran journeyman Geno Smith played quite well in Wilson’s place vs. the Rams in completing 10-for-17 for 131 yards with a TD and pick, which may not have been his fault. Smith will make his 32nd NFL start and is 12-19 in the previous 31. His last was in 2017 with the Giants.

Top running back Chris Carson missed Week 5 with a neck injury and is questionable. Seattle’s defence is on pace to allow an NFL-record amount of yardage, currently last in the league in giving 450.8 ypg. The Seahawks are 2-7 ATS in their past nine on the road.

Pittsburgh Steelers

Pittsburgh snapped a three-game losing streak and scored a season-high 27 points in Sunday’s eight-point win against Denver, which has a very good defence. Ben Roethlisberger hasn’t been particularly good this year but was a solid 15-for-25 for 253 yards and two scores. Rookie first-round running back Najee Harris had easily the best game of his young career with 23 catches for 122 yards and a TD.

Receiver Chase Claypool, from British Columbia, returned after missing a game injured and had five catches for 130 yards and a TD. However, fellow starting wideout JuJu Smith-Schuster suffered a season-ending injury. Linebacker Devin Bush left with a groin injury and his status for Sunday is in question. The Steelers are 2-5 ATS in their past seven at home.

NFL Prediction: Who Will Win Seahawks vs. Steelers?