Saints vs. Panthers Point Spread: NFL Week 3 Odds, Prediction

Jeremy Perry | Updated Sep 20, 2022

Can the Panthers pick up their first win of the season at home in Carolina against the visiting New Orleans Saints?

September 25, 2022, 1:00 PM ET
Bank of America Stadium
Pointspread -2 -106
Moneyline -131
Over / Under o +41


Betting Action


Pointspread +2 -114
Moneyline +109
Over / Under u +41


Betting Action


The New Orleans Saints are fresh off a stinging loss to the Tampa Bay Buccaneers in their home-opener last Sunday. It was a game where the momentum seemingly vanished for the Saints in the final quarter as Jameis Winston threw three interceptions on the afternoon – including a pick-six.

Meanwhile, the Carolina Panthers fared equally bad, dropping to 0-2 on the season with a tough defeat at the hands of the New York Giants. Can the Panthers finally get into the win column or will the Saints keep them at the bottom of the standings?

New Orleans is a 3-point favourite to win on the NFL odds, with a total of 40.5.

NFL Point Spread and Betting Analysis

Week 3 has been kind to the Saints as they’ve covered four of their last five in this week. They are also 11-3 ATS in their last 14 road games when going up against a team with a losing home record on the year. As for the total, New Orleans has seen the under cash out in their past five games when they are following an ATS loss.

On the other hand, Carolina has not performed well against the spread at home lately. They hold a 6-19-1 ATS record in their past 26 at home. They are also a measly 2-14 against the spread in their past 16 matchups overall.

New Orleans Saints

It was awfully clear that the Saints lost all signs of life against Tampa Bay after a crucial Mark Ingram fumble at the goal line last week. From that point, Winston began forcing throws that just weren’t there to try and regain the momentum, but to no avail. He threw three interceptions – including a pick-six that crushed the team’s hopes. Now the main concern is that he has a back injury that might have been the cause for the errant throws.

It wasn’t all bad though as the Saints’ defence looked like they’re for real. They held Tom Brady to just one touchdown pass, which came in the fourth quarter after the Saint’s critical turnover. They were flying all over the ball and once again looked like a top unit in the league. They should be able to feast on a Panthers offence that has really laboured early on. Quarterback Baker Mayfield is currently 32nd in QBR, which should give the Saints defence an opportunity to control the game.

Carolina Panthers

The Carolina Panthers are winless and not much is going right for them. Mayfield has to shoulder some blame – especially since his completion percentage is just at 53.6 on the season. He completed 48.3 per cent of his passes for 145 yards and a touchdown against the Giants last week. Christian McCaffrey was the only bright side of the offence again, rushing for 102 yards while adding 26 yards through the air.

As for Carolina’s defence, they have just played well enough to win in each of the first two games. And keep in mind that they are yet to get a turnover this season.

The Panthers have lost both games by a combined five points. If the defence gets a turnover or two, and Mayfield plays better, they could generate their first win of the year.

NFL Prediction: Who Will Win Saints vs. Panthers?