That 27–25 defeat in the Divisional Round ended their Super Bowl hopes and left Lamar Jackson with unfinished business. The Bills, meanwhile, return from a 13-4 campaign that ended in the AFC Championship against Kansas City and enter 2025 once again among the favourites in the AFC.

Sports Interaction list Baltimore as a slim 1-point road favourite on the NFL Week 1 odds. The Bills sit as +105 underdogs on the moneyline, while the total for this primetime matchup is set at 50.5.

Sunday Night Football Point Spread and Betting Odds

These teams split their regular-season meetings in 2024, each winning at home, before Buffalo edged Baltimore in the playoffs. The under has been a consistent trend in this rivalry, cashing in seven of the past eight matchups.

Buffalo has been reliable at Highmark Stadium, covering in 12 of 16 games there last season. Baltimore, by contrast, has struggled historically as a Week 1 road underdog, failing to cover in recent openers away from home. With both teams viewed as Super Bowl contenders entering 2025, the narrow line reflects just how evenly matched this primetime clash is.

Baltimore Ravens

Lamar Jackson is coming off a career season in which he threw 41 touchdown passes, the most of his career. He also delivered multiple passing scores in both regular-season meetings with Buffalo last year. Sportsbooks have set his Week 1 passing touchdown prop at 1.5, with betting action leaning to the over.

Baltimore’s playoff run ended on a failed two-point try against the Bills, but with Jackson in top form, the Ravens enter 2025 as one of the AFC’s biggest threats.

Buffalo Bills

Josh Allen continues to lead Buffalo’s offense after throwing for over 4,300 yards and 33 touchdowns last season, while adding 10 more scores on the ground. He was central to Buffalo’s playoff win over Baltimore in January and remains one of the NFL’s most productive quarterbacks.

The Bills once again open as contenders in the AFC, and a strong performance under the lights at Highmark Stadium would reinforce their status as a top rival to Kansas City and Baltimore.

Week 1 Prediction: Who Will Win Ravens vs. Bills?

The Ravens enter with momentum and revenge on their minds, and Jackson’s passing form from last season gives them the edge against a Buffalo team still chasing consistency in big games.

RAVENS

Away

27

BILLS

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