Packers vs. Cardinals Point Spread: NFL Week 8 Odds, Prediction

Payton Matthews | Updated Oct 26, 2021

Davante Adams, Packers, 2021

The Green Bay Packers are dealing with a COVID outbreak right now and the lineup could be missing some key players Thursday night.

Green Bay
October 28, 2021, 8:20 PM ET
State Farm Stadium
Pointspread +6.5 -110
Moneyline +210
Over / Under o +51.5


Betting Action


Pointspread -6.5 -110
Moneyline -253
Over / Under u +51.5


Betting Action


Spectacular matchup to kick off NFL Week 8 on Thursday as MVP candidate Aaron Rodgers and the one-loss Green Bay Packers visit MVP candidate Kyler Murray and the unbeaten Arizona Cardinals, who are 6-point favourites on the NFL odds with a total of 53. The spread has been affected by a COVID outbreak on the Packers.

NFL Point Spread and Betting Analysis

Last Thursday’s Broncos-Browns game was hard to watch from an offensive standpoint with two quarterbacks who shouldn’t be NFL starters. This Thursday’s game between Green Bay and Arizona looks to be shootout between three-time NFL MVP Aaron Rodgers of the Packers and 2021 MVP favourite Kyler Murray of the Cardinals.

It’s only Week 8, but this could be huge in terms of earning the No. 1 seed in the NFC playoffs and the lone first-round bye. Obviously, the winner would hold the head-to-head tiebreaker. There will be a ton of Packers fans in the desert for this one in the first prime-time matchup ever between these franchises.

Arizona has won the past three in the series including playoffs, with the most recent matchup a 20-17 Cardinals win at Lambeau Field in December 2018 in wintry conditions. Rodgers was 31 of 50 for 233 yards and a touchdown. The forgettable Josh Rosen was the Cards’ QB then. Murray was winning the Heisman Trophy at Oklahoma.

The total has gone under in five of the past six meetings at Arizona.

Green Bay Packers

It’s still almost unfathomable how bad the Packers looked in a Week 1 blowout loss to New Orleans because they haven’t lost since. Green Bay had little trouble Sunday in a 24-10 win over Washington as Aaron Rodgers threw three TD passes. In doing so, the future Hall of Famer became the fourth quarterback in NFL history with 70 career games with at least three touchdown passes and a passer rating of 100-or-higher. Rodgers also likes to play on Thursdays as he is 10-4 with 32 touchdown passes and five interceptions for a 107.8 rating.

However, Green Bay is dealing with a COVID outbreak right now with superstar receiver Davante Adams and defensive coordinator Joe Barry landing on the COVID/reserve list Monday. Adams alone is worth a few points – this spread jumped from -3.5 to -6 with this news – as he’s the best wideout in the NFL and has 52 catches for 744 yards and three TDs. Green Bay is 5-1-1 ATS in its past seven Thursday games.

Arizona Cardinals

Arizona, the NFL’s last unbeaten team, is 7-0 for the first time since 1974 following a 31-5 victory over Houston on Sunday – gifting the awful Texans a 5-0 lead before waking up. Kyler Murray threw for 261 yards and three scores. He is the only quarterback in the NFL with a passer rating of 100-or-higher in six games this season.

Former Eagles Pro Bowl tight end Zach Ertz made his Arizona debut off a trade and had a TD catch. Coach Kliff Kingsbury returned from missing a game due to COVID. Star pass-rusher Chandler Jones has missed the past two on the COVID list but was activated off that Monday. Jones and teammate JJ Watt (102 sacks each) are two of the active NFL players with at least 100 career sacks. Arizona is tied for the NFL lead in scoring defence (16.3 ppg). The Cards are 5-2 ATS in their past seven as favourites.

Who Will Win Packers vs. Cardinals?