Packers vs. Bills Point Spread: NFL Pre-Season Week 3 Odds, Prediction

Payton Matthews | Updated Aug 25, 2021

The Green Bay Packers wrap up their NFL preseason schedule in upstate New York against the Buffalo Bills on Saturday.

Green Bay
August 28, 2021, 1:00 PM ET
New Era Field
Pointspread +8 -110
Moneyline +280
Over / Under o +37.5
Pointspread -8 -110
Moneyline -341
Over / Under u +37.5

Neither team’s star quarterback is expected to play on Saturday, as Buffalo will rest Josh Allen, while Green Bay will rest Aaron Rodgers. The Bills are 8-point favourites to win on the NFL preseason odds, with a total of 35.

NFL Point Spread and Betting Analysis

It’s quite unusual to see a team favoured in the preseason by more than a touchdown like the Bills are for Saturday’s matchup.

This will be the 14th all-time preseason meeting between the franchises. Green Bay leads the series 10-3, but the clubs haven’t met in an exhibition since 2009 and not in Buffalo since 2005. The last regular season meeting was Week 4 of the 2018 season.  The Packers dominated 22-0 at Lambeau Field. Josh Allen, then a very raw Buffalo rookie quarterback, had a rough day in completing 16-for-33 passing for 151 yards and two picks. He’s not that guy any longer. Aaron Rodgers threw for 298 yards and a score.

They are not scheduled to play this regular season, but it’s very possible they meet in Super Bowl 56, considering both were conference runners-up last season.

Green Bay is 2-4 in preseason games under Coach Matt LaFleur, while Buffalo is 9-6 under Sean McDermott.

Green Bay Packers

Relax, Packers fans, the preseason doesn’t matter. Don’t fret that your team is 0-2, losing both at home, and has been outscored 49-21. Aaron Rodgers has not taken the field and will not until Week 1 of the regular season in New Orleans. Backup quarterback and potential 2022 replacement Jordan Love played the preseason opener but missed last week’s 23-14 loss to the Jets with a minor shoulder injury. He is back at practice this week and should play as Love needs the reps. Third-stringer Kurt Benkert would share snaps. The Packers reduced their roster to 80 players on Tuesday and the notable moves were placing defensive back Will Redmond on season-ending injured reserve – he was a favourite to be the team’s No. 3 safety – and releasing linebacker and 2020 fifth-round pick Kamal Martin.

Buffalo Bills

Buffalo fans might be thinking Super Bowl right now – the franchise has yet to win one, memorably losing four straight in the early 1990s – considering the Bills have won their two preseason games, both on the road, by a combined score of 57-30. Alas, star QB Josh Allen, the NFL MVP runner-up last season, and many other starters haven’t played and aren’t expected to Saturday. It should be plenty of Mitch Trubisky (he has the No. 2 job locked up), Jake Fromm and Davis Webb at QB for this one. The Bills are having a bit of a COVID issue right now with receivers Cole Beasley (he has been perhaps the most outspoken anti-vaccine player in the NFL) and Gabriel Davis, defensive linemen Star Lotulelei and Vernon Butler, and linebackers Matt Milano and AJ Klein sent home in the COVID safety protocol. The Bills had a vaccinated trainer test positive for COVID-19 on Tuesday. Teams with low vaccination rates are simply going to be at a major disadvantage when games count.

NFL Prediction: Who Will Win Packers vs. Bills?