NFL Point Spreads Week 16: Best Picks Against the Spread

Ricky Rothstein | Updated Dec 20, 2016

NFL: Minnesota Vikings at Green Bay Packers

It’s the penultimate week of the 2016 NFL regular season, and we have another head-coaching job opening in the league. The Jacksonville Jaguars were expected to fire Coach Gus Bradley after the season but ownership decided to pull the plug Sunday after his team blew a 13-point lead and lost in Houston — the Jags’ ninth loss in a row. It was literally done right after the game, so Bradley had to suffer through what had to be an uncomfortable flight home with the team. This was deserved as Bradley’s record there was a gruesome 14-48. Here’s a quick look at all Week 16 matchups with Sports Interaction NFL lines. Games on Saturday — yes, Christmas Eve — unless noted.

New York Giants at Philadelphia Eagles, Thursday

Point spread: New York -3 Total: 42 The final Thursday night game of the year as the NFL doesn’t want teams playing on a short turnaround in Week 17. This means everything to the playoff-hopeful Giants and zip to the Eagles. I will have an in-depth preview later this week. Pick ATS: Giants

Miami Dolphins at Buffalo Bills

Point spread: Buffalo -3.5 Total: 42 This should be the final home game of the Bills coaching career of Rex Ryan as he’s expected to be fired right after the season’s conclusion with Buffalo continuing the NFL’s longest active playoff drought. The Dolphins are fighting for a wild-card spot so this is a must win as backup QB Matt Moore starts for the second straight week in place of the injured Ryan Tannehill. Miami beat visiting Buffalo 28-25 in Week 7. Jay Ajayi rushed for 214 yards and a touchdown and Tannehill threw for one. The Bills were held to 267 yards. Pick ATS: Bills

New York Jets at New England Patriots

Point spread: New England -16.5 Total: 43.5 All last-place New York can do is play spoiler as the Patriots have won the AFC East for a record eighth straight season, but they still are competing for the No. 1 overall seed in the AFC playoffs. The Jets gave the visiting Patriots all they could handle in Week 12, with New England escaping 22-17 on a Tom Brady touchdown pass with 1:56 remaining. Pick ATS: Jets

Tennessee Titans at Jacksonville Jaguars

Point spread: Tennessee -4.5 Total: 43.5 It’s a must-have game for the Titans to keep their AFC South title hopes alive. The Jaguars, as usual this decade, are playing for Top-5 draft status at this point in the season and will be under an interim coach. Tennessee beat visiting Jacksonville 36-22 in Week 8. Marcus Mariota threw for 270 yards and two touchdowns. An unusual streak will end here if the Jaguars don’t win as these teams have split the season series every year since 2009. Pick ATS: Titans

Minnesota Vikings at Green Bay Packers

Point spread: Green Bay -6.5 Total: 43.5 Crucial game in the NFC North and for a possible wild-card spot. The Packers’ hopes for the division title are still alive as they are just a game behind first-place Detroit and those teams play in Week 17. The Vikings’ playoffs hopes are on life support after a blowout loss at home to Indianapolis on Sunday despite star running back Adrian Peterson playing for the first time since Week 2. In that Week 2 game, the Vikings beat the Packers 17-14, but Peterson injured his knee. It was also QB Sam Bradford‘s debut with Minnesota, and he outplayed Aaron Rodgers. Pick ATS: Packers

San Diego Chargers at Cleveland Browns

Point spread: San Diego -6 Total: 44 One of the few Week 16 games in which neither team has any playoff relevance. It’s also the Browns’ last best chance to avoid a winless season. It’s their final home game, and the Chargers have little motivation, are a warm-weather team playing in the presumed cold in an early 10 a.m. Pacific time kickoff. If there were ever circumstances lined up for a Cleveland win, this is it. Pick ATS: Browns

Washington Redskins at Chicago Bears

Point spread: TBA Total: TBA Short week for Washington, which hosted Carolina on Monday night. The Redskins are right in the wild-card chase, while the Bears are last in the NFC North and having their worst season of the century. Chicago also hosted Washington late last season and the Redskins won 24-21 behind 300 yards passing and a touchdown from Kirk Cousins. Former Bears kicker Robbie Gould missed a tying 50-yard field goal attempt with less than two minutes left. Pick ATS: Bears

Atlanta Falcons at Carolina Panthers

Point spread: TBA Total: TBA In Week 16 last year, the nothing-to-play-for Falcons upset the unbeaten Panthers in Atlanta, 20-13. This time around, it’s Carolina that is eliminated from the playoffs — plus on a short week after visiting Washington on Monday. The NFC South-leading Falcons go for the season sweep after a 48-33 home win over the Panthers in Week 4. Atlanta set NFL history that day in becoming the first team to have a quarterback throw for 500 yards (Matt Ryan 503) and a receiver with at least 300 yards (Julio Jones 300) in the same game. Pick ATS: Panthers

Indianapolis Colts at Oakland Raiders

Point spread: Oakland -4 Total: 53 The Raiders clinched their first trip to the playoffs since 2002 on Sunday with a close win in San Diego. Oakland would win the AFC West and get a first-round playoff bye with a victory here and a Kansas City home loss to Denver. Indianapolis looked great Sunday in pounding the Vikings on their field, but the Colts will miss the playoffs if they lose this game and probably will even they win. Pick ATS: Raiders

Tampa Bay Buccaneers at New Orleans Saints

Point spread: New Orleans -3.5 Total: TBA Second game between these two in 13 days. In Week 14, the Bucs beat the visiting Saints 16-11, intercepting Drew Brees three times. Neither offense did much on a rainy day. While New Orleans is out of the playoff hunt, the Bucs most likely need a win here to keep their NFC South and wild-card hopes alive after losing Sunday night in Dallas. Pick ATS: Saints

Arizona Cardinals at Seattle Seahawks

Point spread: Seattle -9 Total: 43.5 Seattle clinched the NFC West with last Thursday’s easy win over Los Angeles, which eliminated Arizona from the playoff hunt. The Seahawks still have the motivation of playing for a first-round playoff bye. These teams played one of the ugliest games of the season in Week 7, a 6-6 tie in the desert. Both kickers missed potential winning chip-shot field goals in overtime. Arizona dominated that game statistically. Pick ATS: Seahawks

San Francisco 49ers at Los Angeles Rams

Point spread: Los Angeles -3 Total: 40.5 Absolutely nothing at stake here, other than the 49ers perhaps ending their 13-game winning streak. A game between baseball’s San Francisco Giants and Los Angeles Dodgers probably would have more scoring than this might. The 49ers’ lone win was a Week 1 28-0 domination of the Rams. But neither starting QB that day will play here barring injury. Current Rams starting QB Jared Goff did suffer a concussion in last Thursday’s loss in Seattle so he might have to sit in favour of Case Keenum, who was awful in that Week 1 loss. Pick ATS: Rams

Cincinnati Bengals at Houston Texans

Point spread: Houston -1.5 Total: 41.5 This is the Saturday night game. Cincinnati was eliminated from playoff contention after blowing a big home lead and losing to Pittsburgh on Sunday. Houston rallied from a 13-0 hole against Jacksonville and won 21-20 behind backup QB Tom Savage. Coach Bill O’Brien pulled struggling free-agent bust Brock Osweiler in the second quarter after two interceptions, and Savage, a 2014 fourth-round pick, played very well in his place. O’Brien hasn’t named his starter for this week, but there’s no possible way he can go back to Osweiler or his players might stage a revolt. Pick ATS: Texans

Baltimore Ravens at Pittsburgh Steelers, Sunday

Point spread: Pittsburgh -4.5 Total: 44.5 Arguably the most important game of Week 16. The Steelers take the AFC North with a victory, but if Baltimore wins it would tie for first and own the tiebreaker via a season sweep. The loser could miss the playoffs entirely, especially if it’s the Ravens. Baltimore beat visiting Pittsburgh 21-14 in Week 9. Neither team even had 280 yards of offense. The Ravens got about a third of their total yardage on a Joe Flacco 95-yard touchdown pass to Mike Wallace. Pick ATS: Steelers

Denver Broncos at Kansas City Chiefs, Sunday

Point spread: Kansas City -4 Total: 38 Another big one in the AFC West. The Broncos might not even get a shot to defend their Super Bowl as their playoff chances are barely alive and will be gone with a loss. Kansas City goes for the season sweep after winning 30-27 in overtime at Denver in Week 12. That was a completely crazy game in the second half. Look for an in-depth preview of this later this week. Pick ATS: Chiefs

Detroit Lions at Dallas Cowboys, Monday

Point spread: Dallas -7 Total: TBA The final Monday night game of the season and it features division leaders. The Cowboys might have clinched the NFC East title and top seed in the NFC playoffs before they even take the field for this one and thus might have little motivation. The Lions are trying to hold off the streaking Packers in the NFC North. Look for an in-depth preview here at Sports Interaction. Pick ATS: Cowboys if they have something to play for, Lions if not