Jaguars vs. Titans NFL betting odds, picks: Jaguars big road favourites
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Kevin Tompkins
We’re into the double-digit weeks now, and in Week 10, we’ve got an AFC South clash as the 6-2 and rested Jacksonville Jaguars head to Nissan Stadium in Nashville to take on the scuffling 1-7 Tennessee Titans.
The Jaguars have won five of their last six games and look like one of the AFC’s best teams. Jacksonville blew out the Indianapolis Colts in Week 8, with Trevor Lawrence needing just 14 pass attempts before giving way to backup Quinn Ewers, and then had little trouble with a Baltimore Ravens team playing a third-string quarterback in undrafted rookie Joe Fagnano. The Jaguars are 4-1 at home and 2-1 on the road, and they’ll benefit from extra rest after playing on Thursday. Jacksonville also went all-in at the trade deadline, adding defensive tackles Jordan Davis and Davon Godchaux, and safety Jessie Bates III.
Meanwhile, the Titans are coming out of their bye after two straight gut-punch losses. Tennessee fell 27-24 at home to the Cleveland Browns on a walk-off field goal in Week 7, then took the Cincinnati Bengals to overtime on the road before falling 43-36. The Titans are still 0-4 at Nissan Stadium this season.
Check out a full list of Week 10 NFL odds.
Jaguars vs. Titans Kickoff, Weather, TV, Streaming Info
This AFC South showdown kicks off Sunday at 1:00 PM ET at Nissan Stadium in Nashville, Tennessee.
The game will air on FOX, with streaming available DAZN.
The weather forcast for Week 10’s game calls for a cool, damp afternoon, with temperatures around 50 degrees and a better-than-even chance of rain. The Jaguars just handled a rainy night in Baltimore without much trouble, but the Titans have their own issues no matter the weather.
Week 10 NFL score predictions.
NFL Betting Odds, Point Spread, Trends
The visiting Jaguars are 10.5-point road favourites with a -535 money line, making them the biggest favourites on the Week 10 board. The home Titans are placed at +400 on the money line, and the total sits at 46.5.
This season, Jacksonville has been one of the league’s best teams on both sides of the ball. The Jaguars are averaging 28.6 points per game while allowing just 15.1, and they’re plus-nine in turnover differential after forcing six takeaways over their last two games.
Lawrence is playing at an MVP level, with 17 touchdown passes against four interceptions through eight games, and defensive coordinator Anthony Campanile’s system has been especially stingy against the run. That unit just got significantly better, as general manager James Gladstone sent five draft picks, including a 2027 first-rounder and two second-round picks, to land Davis, Godchaux and Bates before the deadline, which should only make life harder for a Titans offence that leans on Tony Pollard and Carnell Tate, who may return after missing Week 8’s game and then taking the bye to rest his shoulder.
As for the Titans, the offence finally registered a pulse in Cincinnati. Cam Ward threw for a career-high 304 yards and two touchdowns, and Pollard has topped 100 rushing yards with two scores in each of his last two games. The problem is a defence that allows 24.9 points per game and has failed to close out back-to-back games in the fourth quarter. Tennessee is scoring just 18.0 points per game and is learning that life without a dominant interior threat like Jeffrey Simmons is a bit more difficult.
With the Jaguars’ defence facing a Titans offence that has been inconsistent all year, siding with Jacksonville makes sense, though 10.5 points is a big number in a division game. Tennessee’s recent offensive surge could give bettors a second thought, but let’s be real: Cincinnati’s defence is nowhere near Jacksonville’s.
NFL Player Odds and Props
Jacksonville Jaguars
Bhayshul Tuten OVER 68.5 rushing yards
Tuten has scored in back-to-back games and has four rushing touchdowns on the season, and the extra rest after the Thursday night win should help with the ankle and foot injury he played through in Baltimore.
As 10.5-point favourites, the Jaguars should be protecting a lead in the second half, and that means a steady diet of carries against a Titans defence that just gave up 43 points and has struggled to get off the field. The risk is the committee, as Chris Rodriguez Jr. has operated as a closer of sorts for the Jaguars, which limits our desire to take a Trevor Lawrence prop here. But Tuten is the back Jacksonville leans on in neutral situations, and a positive game script and a few chunk plays should give him the volume to clear this 68.5-yard number.
Tennessee Titans
Tony Pollard UNDER 56.5 rushing yards
Pollard has been on a heater, topping 100 rushing yards and at least two touchdowns in each of his last two games against the Browns and Bengals. But this is a completely different test. The Jaguars held Derrick Henry to 57 yards on 17 carries last week, and they just added defensive tackles Davis and Godchaux to plug the middle. Game script works against Pollard too: as double-digit underdogs, the Titans are likely to abandon the run and pass their way out of it. The heater for Pollard ends in Week 10, with the Jaguars holding him to under 56.5 rushing yards.
Jacksonville Jaguars
Lawrence has 1,932 passing yards and an 18:4 touchdown-to-interception ratio on the season, and he has spread the ball around to multiple receivers, including Brenton Strange and Parker Washington, who hauled in a 50-yard touchdown against Baltimore, plus rookie tight end Nate Boerkircher and Jakobi Meyers also making big plays. The backfield is a committee, with Tuten playing through injury alongside Rodriguez Jr. The run game has been a bit hit or miss this season, but Jacksonville has the second half of the season to round into form.
The defence is the reason the Jaguars are a contender. Jacksonville held Henry to 57 yards on 17 carries and limited the Ravens to 227 total yards, with Montaric Brown and Jourdan Lewis each picking off a pass. The unit played without defensive lineman DaVon Hamilton for the first time this season and didn’t miss a beat, and it’s about to get even deeper. Davis, acquired from the Eagles for a 2027 first-round pick and a 2029 second-rounder, and Godchaux, a 10-year veteran who heads to Duval County from the New Orleans Saints, give Jacksonville two massive bodies in the middle to cover for Hamilton’s absence.
Bates, acquired from Atlanta, adds a proven ball-hawking safety to a defence that has already forced six takeaways over its last two games. If any of the three are cleared to suit up in just six days with the team, Pollard’s run lanes could get VERY tight.
Tennessee Titans
After cracking 200 passing yards just once through the first seven weeks, Ward finally broke through in Cincinnati, and head coach Robert Saleh said afterward that he saw a real step forward from his second-year quarterback. Pollard has been the steadiest piece of the offence, while rookie Tate and Wan’Dale Robinson, who caught the go-ahead touchdown late in regulation against the Bengals, give Ward reliable targets on the outside.
The defence has generated big plays, with Amani Hooker intercepting Joe Burrow three times and Jacob Martin adding three sacks in that loss, but it has also given up 70 points over the last two games and couldn’t hold a late lead in either. Hooker is now in Buffalo, so Tennessee will miss his ball-hawking ability in the secondary. Facing a Jaguars offence that rarely makes mistakes, Tennessee will need another opportunistic day to have a real chance at the upset.
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