How to Bet Week 7 of the 2025 NFL Season: Are the Lions poised for a bounce-back game?
Last week started and ended with two shocking losses in the NFL as the Eagles fell to the Giants on Thursday and the Bills were upset against Atlanta on Monday.
We’re back to make sense of the storylines and the stats heading into Week 7.
Here’s everything you need to know to bet Week 7 of the 2025 NFL season.
Don’t forget to check out Sports Interaction’s complete list of NFL game odds, NFL futures and NFL specials and props.
TNF Steelers at Bengals
It’s a battle between two AFC North teams trending in opposite directions to open Week 7. The Steelers lead the division with a 4-1 record and come in off three straight wins. The Bengals are lucky to be second in the division at 2-4 and they’ve lost all four games since Joe Burrow’s possible season-ending injury.
Early money came in heavy on Pittsburgh in this spot, pushing the line up a full point from it’s opening at Steelers -4.5 to -5.5. I think that’s the sweet spot to take Cincinnati to cover.
The Bengals’ defence isn’t exactly top of the league, but they’ll be facing a Pittsburgh offence that ranks 29th in the NFL in average offensive yards per game (277.8) while averaging just 23.8 points per game.
I also like Cincinnati’s offence to improve under Joe Flacco. They looked a lot better in the second half of last week’s loss to Green Bay with Flacco getting the ball to Ja’Marr Chase and I expect continued growth as Flacco gets more comfortable with the playbook.
Steelers head coach Mike Tomlin has also historically struggled in Thursday games, posting a losing record both straight up and against the spread. Tomlin is also an abysmal 2-9 SU away from home on Thursday’s.
Pittsburgh is clearly better than the Bengals and I think they’ll win, I just don’t think it will be a blowout. Give me the points in a divisional home game on a short week.
Pick: Bengals +5.5, Steelers moneyline
Rams at Jaguars (in London)
The last of three games scheduled for London this season features two 4-2 teams, with the Jaguars technically hosting the Rams at historic Wembley Stadium. Jacksonville is looking to bounce back from a home loss against the Seahawks, while L.A. is riding high after dominating the Ravens.
I almost hate to say it, but I like the Jags in this spot. Not only will they be prepared because they play in London more than any other team, but game planning for the Rams will be a lot easier with star receiver Puka Nacua out with an ankle injury. Remember, Jacksonville has played 13 international games since 2013 and L.A. has only played three.
The last two weeks of London games have brought us game totals of 38 between the Vikings and Browns and just 24 in the Broncos and Jets snoozefest. I think that trend continues this week.
The Rams boast a top-10 defence in the NFL and the Jaguars have handled themselves on that side of the ball. Jacksonville also has an above average rushing offence, which should slow down the game.
Pick: Jaguars +3, Under 44.5
Colts at Chargers
A pair of division leaders meet in L.A. on Sunday, with the AFC West Chargers hosting the AFC South Colts. At 4-2, L.A. is in the driver’s seat to finally dethrone Kansas City for the division, while Indianapolis is easily the most surprising 5-1 team in the league.
This is the Colts’ toughest test up to this point of the season. The only other top team Daniel Jones and co. have faced is the Rams and they walked away as losers by a touchdown.
For the injury-riddled Chargers, this week is a chance to put behind them last week’s debacle in which they only managed to beat a terrible Dolphins team by two points.
I’m targeting a higher scoring game for these playoff bound teams. L.A.’s defence scares me for the wrong reasons as they’ve now given up 27 points in back-to-back weeks against Washington and Miami offences that don’t measure of to what the Colts can do.
Indianapolis’ offence is absolutely humming this season. They rank top-10 in total offence, passing offence and rushing offence and they are the highest scoring offence in the NFL with an average of 32.3 points per game.
Prepare for a shootout in the City of Angels.
Pick: Total Over 48.5
SNF Falcons at 49ers
The 3-2 Atlanta Falcons are keeping pace in the NFC South with back-to-back wins, including a shocking 10-point triumph over Buffalo last week. Meanwhile, the 49ers are one of three teams in the competitive NFC West with a 4-2 record following last week’s loss in Tampa Bay.
After a rash of early-season injuries, San Francisco is finally getting healthier, at least on offence. Quarterback Brock Purdy, receiver Ricky Pearsall and tight end George Kittle could all be active on Sunday.
This is a tough spot for the Falcons, who are playing on a short week and travelling across the country. And as the hip kids say, I’m “sus” on this team as their three wins came against opponents all dealing with significant injury issues.
Even if Mac Jones does end up leading the offence this week, I still like the 49ers to roll.
Pick: 49ers -2
MNF Buccaneers at Lions
The better of the two Monday night games is clearly 4-2 Detroit hosting 5-1 Tampa Bay. The Lions are licking their wounds after a beatdown loss in Kansas City last week, while the Bucs looked good in a win against San Francisco.
This line has flip-flopped a bit, opening at Detroit -5.5 before moving to -4.5 and back again to -5.5, so keep that in mind when locking this bet in.
Baker Mayfield is playing at an MVP calibre level this season, but Tampa Bay’s receiving core is really banged up, with Chris Godwin and Mike Evans on the shelf, so I don’t know who Mayfield is expected to target this week. The latest loss is star rookie Emeka Ekbuka, who went down with a hamstring injury last week.
I like this as a bounce-back spot the Lions. Detroit boasts the second-highest scoring offence in the NFL (31.8 points per game) and they’re up against a weak Buccaneers defence.
Pick: Lions -5.5
