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Colts vs. Vikings NFL Betting Odds, Picks:

Final Score
Indianapolis
Colts
Minnesota
Vikings
10
16
Indianapolis Colts
Minnesota Vikings
Scoreboard 1 2 3 4 Odds
Indianapolis Colts 2-7 7 3 0 0 +42.5
Minnesota Vikings 6-2 0 6 0 10 -7

Colts vs. Vikings NFL Week 7 Betting Odds, Picks: Spread continues to move in Minnesota’s favour

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Week 7 sees one of the NFC’s two unbeaten teams back home at U.S. Bank Stadium, where the 5-0 Minnesota Vikings host a reeling 2-4 Indianapolis Colts team that has dropped two straight.

Minnesota enters off a bye after beating New Orleans 23-13 in Week 5, while Indianapolis is coming off a 26-20 home loss to Tennessee in which it blew a 13-0 lead. This defeat resulted in the firing of GM Chris Ballard, and it will be interesting to see where this franchise goes next.

The Vikings’ perfect start has come with an unlikely quarterback. Minnesota traded J.J. McCarthy to the Giants in exchange for a 2027 fifth-round draft pick on September 28 and has ridden Kyler Murray, who signed a one-year, league-minimum deal this offseason. Murray has started every game since Week 3 and has the Vikings’ bottom-ranked offence winning anyway, propped up by a Brian Flores defence that leads the NFL in points allowed (12.8 per game) and ranks second in total yards allowed (259.8 per game).

Indianapolis, meanwhile, is dealing with a quarterback controversy of its own. Daniel Jones has thrown six interceptions in six starts, including two in Sunday’s loss that both came inside Tennessee’s 20-yard line, and coach Shane Steichen is sticking with him over Anthony Richardson despite fans booing the team off the field.

Colts vs. Vikings Kickoff, Weather, TV, Streaming Info

Here’s everything you need to know for Sunday’s Week 7 game between Minnesota and Indianapolis:

  • Date: Sunday, October 25, 2026
  • Kickoff: 1 p.m. ET
  • Venue: U.S. Bank Stadium, Minneapolis, MN
  • Weather: U.S. Bank Stadium has a fixed indoor roof, so conditions are climate-controlled.
  • TV: CBS and streaming on Paramount+

NFL Betting Odds, Point Spread, Trends

Minnesota opened as a 5.5-point favourite and has settled at -6.5 (-105) on the NFL odds, with Indianapolis getting +6.5 (-115). The Vikings carry a -290 moneyline price to Indianapolis’s +235, and the total sits at 41.5, with both sides at -110.

The trends lean toward the Under. Minnesota has gone Under in four of its five games and has held its last four opponents to 16 points or fewer. Against the spread, the Vikings are 4-1 this season while the Colts are 3-3.

NFL Player Odds and Props

Minnesota Vikings

RB Aaron Jones ran for 113 yards and a touchdown in the Week 5 win over New Orleans, and with Minnesota expected to lean on the ground game and clock control again behind its top-ranked defence, another workhorse outing is in play against a Colts run defence that has had its own injury issues up front while allowing 122.5 rushing yards per game.

Indianapolis Colts

RB Jonathan Taylor has stayed productive even as the Colts have scuffled, rushing for 492 yards and seven touchdowns through six games and passing 8,000 for his career in the loss to Tennessee. He’ll be the engine of any Indianapolis response, especially with Daniel Jones under pressure to protect the ball. However, the Vikings allow the fifth-fewest rushing yards per game this season (86.6), so I’d avoid Taylor’s rush total.

Indianapolis Colts

Jones’ turnover issues have piled up alongside a rash of other injuries. CB Sauce Gardner is doubtful with a calf injury, WR Alec Pierce is on injured reserve, and TE Tyler Warren missed his first career game last week with a groin issue.

Punt returner Anthony Gould (concussion) and punter Rigoberto Sanchez also left Sunday’s loss, and Ashton Dulin and Jaylon Carlies have each sat out two straight games.

Steichen’s team arrives as a 2-4 underdog against one of the best defences in the NFL, and I can’t see how they pull out a win in this one.

Minnesota Vikings

Murray has quietly been efficient since taking over full-time in Week 3, throwing for 229 yards and a touchdown on 24-of-30 passing in the win over the Saints. WR Justin Jefferson, who missed Week 4 with an ankle injury, caught six passes for 79 yards and a score in his return and got an extra week of rest during Minnesota’s bye.

The Vikings’ defence has been the story of the season: opposing quarterbacks own just a 60.7 passer rating against it, the lowest any Minnesota defence has allowed through five games in five years, and the unit leads the league in quarterback hits.

Colts vs. Vikings Week 7 Score Prediction

COLTS

Away
13
Indianapolis Colts Logo
Minnesota Vikings

VIKINGS

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