After opening the season 7-0, the Cardinals have now dropped four of their last seven games, including an embarrassing loss to Detroit last week.
Arizona’s season continued to take a rapid decline last week as their embarrassing 30-12 loss in Detroit cost them a chance to clinch a playoff spot for the first time since 2015. The Cardinals will look to get back on track and improve their poor home record on Saturday when they host the Colts. Indianapolis is looking strong down the stretch and come into State Farm Stadium following a 27-17 win over the Patriots last week.
Arizona opened as a 5-point favourite to win on the NFL odds, but the line has fluctuated and the game is hovering around a pick’em as of Thursday afternoon. The total is set at 49.5.
NFL Point Spread and Betting Analysis
It’s a rare meeting between these teams as they haven’t played since Arizona rolled out of Indy with a 16-13 overtime win in September 2017. That result hasn’t swayed Sports Interaction bettors, with about 70 per cent of action taking the Colts. The total is a closer split, with the Over/Under skewed around 60/40 in favour of the Over.
The Colts are making a run for the AFC South title and sit just one game back of Tennessee. Indianapolis has won five of their last six games overall and they’re a healthy 4-2 on the road this season. They’ve gone 9-5 against the spread for the season and covered in their last five road contests. The total has gone Over in five of the Colts’ last six games against NFC opponents.
Arizona’s has surprisingly struggled at home this season, where they’re 4-4 on the year and have lost three straight games. They’re 9-5 ATS overall and have failed to cover in four of six home dates. The total has gone Over in four of the Cardinals’ last six games.
Indianapolis Colts
Indianapolis has quietly been one of the NFL’s top teams since October, winning eight of 12 games in that time, with two of those losses coming in overtime. After breaking New England’s seven-game win streak last week, it might be time to look at the Colts as legitimate contenders. Running back Jonathan Taylor has skyrocketed up the NFL MVP odds, sitting with the third-best odds to win at +670. A non-quarterback hasn’t won the MVP since running back Adrian Peterson did it with Minnesota in 2012. Taylor racked up 170 rushing yards and ran for a score for the 11th straight game last week, surpassing 100 rushing yards for the eighth time in 11 games. No other running back is within 300 yards of Taylor this season.
One offensive concern is the lack of production from quarterback Carson Wentz. Wentz was just 5-for-12 against the Patriots, finishing with 57 passing yards with one touchdown and interception each. It’s the fourth time in the last five games that Wentz has failed to pass for more than 180 yards.
Arizona Cardinals
After opening the season 7-0, the Cardinals have now dropped four of their last seven games following the embarrassing loss to Detroit last week. Quarterback Kyler Murray looked shaky against the Lions, going 23-of-41 for 257 yards with a touchdown and an interception. Christian Kirk picked up 94 receiving yards and a score, while Chase Edmonds led Arizona’s running backs with 53 yards on six carries.
Instead of clinching a playoff spot last week, the Cardinals’ loss dropped them from first to fourth in the NFC and they now lead the Rams by just a single game in the NFC West. There’s still a few scenarios that would see Arizona earn a playoff berth this week, but they’ll require some other playoff contenders to lose or tie. Clinching a playoff spot this week would be huge for the Cardinals as they’ll be without star receiver DeAndre Hopkins (knee) for the rest of the regular season and into January.
NFL Prediction: Who Will Win Colts vs. Cardinals?
Line History
Sports Interaction customers are placing their bets on:
time | fav | line | total |
---|---|---|---|
Opening 20 Dec 10:11am | IND | -2 -110 | O +50 -108 |
Closing 26 Dec 1:14am | IND | -3 -110 | O +48.5 -117 |
- Regular Season
- Playoffs
Colts Team Leaders
Touchdowns |
20 |
Rushing |
1811 |
Passing |
3563 |
Receiving |
88 |
Sacks |
7 |
Interceptions |
4 |
Touchdowns |
18 |
Rushing |
752 |
Passing |
3787 |
Receiving |
77 |
Sacks |
11 |
Interceptions |
4 |
Touchdowns | |
Rushing | |
Passing | Did not qualify |
Receiving | |
Sacks | |
Interceptions |
Touchdowns |
1 |
Rushing |
28 |
Passing |
137 |
Receiving |
6 |
Sacks |
1 |
Interceptions |
0 |
- Regular Season
- Playoffs
Cardinals Team Leaders
Touchdowns |
20 |
Rushing |
1811 |
Passing |
3563 |
Receiving |
88 |
Sacks |
7 |
Interceptions |
4 |
Touchdowns |
18 |
Rushing |
752 |
Passing |
3787 |
Receiving |
77 |
Sacks |
11 |
Interceptions |
4 |
Touchdowns | |
Rushing | |
Passing | Did not qualify |
Receiving | |
Sacks | |
Interceptions |
Touchdowns |
1 |
Rushing |
28 |
Passing |
137 |
Receiving |
6 |
Sacks |
1 |
Interceptions |
0 |
Weather

condition | dome |
Injuries
Rock Ya-Sin (CB)
Mo Alie-Cox (TE)
George Odum (S)
Michael Pittman Jr. (WR)
Chris Reed (G)
E.J. Speed (LB)
Xavier Rhodes (CB)
Carson Wentz (QB)
Marlon Mack (RB)
Braden Smith (T)
Greg Mabin (CB)
Zach Allen (DE)
Justin Pugh (OL)
Isaiah Simmons (LB)
Antonio Hamilton (CB)
Jonathan Ward (RB)
Zach Allen (DE)
Chase Edmonds (RB)
Dennis Gardeck (LB)
Tanner Vallejo (LB)
Injuries
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Rock Ya-Sin (CB) | day-to-day | Ankle - 09 / 01 / 22 | 0-1 | 0-1 | + - |
Ya-Sin is dealing with an ankle injury, and it is undecided if he will be active for postseason play. |
|||||
Mo Alie-Cox (TE) | Prob Sun | Knee - 05 / 01 / 22 | 0-1 | 0-1 | + - |
Alie-Cox is tending to a knee ailment, but it is not expected to affect his status against the Jaguars on Sunday. |
|||||
George Odum (S) | Prob Sun | Calf - 05 / 01 / 22 | 0-1 | 0-1 | + - |
Odum is expected to lace up against the Jaguars on Sunday despite a calf injury. |
|||||
Michael Pittman Jr. (WR) | Prob Sun | Ribs - 05 / 01 / 22 | 0-1 | 0-1 | + - |
Pittman Jr. is projected to take the field for Sunday's game versus the Jaguars despite a rib injury. |
|||||
Chris Reed (G) | Prob Sun | Illness - 05 / 01 / 22 | 0-1 | 0-1 | + - |
Reed is ailing from an illness, but it is projected that he will partake in Sunday's battle with the Jaguars. |
|||||
E.J. Speed (LB) | Prob Sun | Hip - 05 / 01 / 22 | 0-1 | 0-1 | + - |
Speed has a hip injury, but it is anticipated that he will be a participant in Sunday's matchup with the Jaguars. |
|||||
Xavier Rhodes (CB) | day-to-day | Hamstring - 03 / 01 / 22 | 0-1 | 0-1 | + - |
Rhodes is bothered by a hamstring injury, and it has yet to be established if he will be available for playoffs. |
|||||
Carson Wentz (QB) | Out indefinitely | Illness - 28 / 12 / 21 | 1-1 | 0-2 | + - |
Wentz has been shifted to the IR/COVID-19 list, and it is unknown when he will return. |
|||||
Marlon Mack (RB) | Out indefinitely | Illness - 27 / 12 / 21 | 1-1 | 0-2 | + - |
Mack has been designated to the IR/COVID-19 list, and a date for his return is unclear. |
|||||
Braden Smith (T) | Out indefinitely | Illness - 27 / 12 / 21 | 1-1 | 0-2 | + - |
Smith has been shuttled to the IR/COVID-19 list, and it is undecided when he will return to action. |
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Greg Mabin (CB) | Out indefinitely | Illness - 19 / 01 / 22 | 0-0 | 0-0 | + - |
Mabin has been added to the IR/COVID-19 list, and there is no timetable for return. |
|||||
Zach Allen (DE) | Prob Mon | Ankle - 14 / 01 / 22 | 0-1 | 1-0 | + - |
Allen has an ankle injury, but it is projected that he will take on the Rams in the NFC wild-card game. |
|||||
Justin Pugh (OL) | Ques Mon | Calf - 14 / 01 / 22 | 0-1 | 1-0 | + - |
Pugh is hobbled by a calf ailment, and it is undetermined if he will line up for the NFC wild-card game versus the Rams. |
|||||
Isaiah Simmons (LB) | Ques Mon | Personal - 14 / 01 / 22 | 0-1 | 1-0 | + - |
Simmons is tending to a personal matter, and it is unclear if he will be active for the NFC wild-card battle against the Rams. |
|||||
Antonio Hamilton (CB) | Prob Mon | Teeth - 14 / 01 / 22 | 0-1 | 1-0 | + - |
Hamilton is battling a tooth issue, but it is anticipated that he will face the Rams in the NFC wild-card game. |
|||||
Jonathan Ward (RB) | Ques Mon | Knee - 12 / 01 / 22 | 0-1 | 1-0 | + - |
Ward is managing a knee injury, and it is undecided if he will suit up for the NFC wild-card game against the Rams. |
|||||
Zach Allen (DE) | Ques Sun | Ankle - 06 / 01 / 22 | 1-1 | 1-1 | + - |
Allen is bothered by an ankle injury, and it is uncertain if he will take on the Seahawks on Sunday. |
|||||
Chase Edmonds (RB) | Prob Mon | Ribs - 06 / 01 / 22 | 1-1 | 1-1 | + - |
Edmonds has injuries to his ribs and toe, but it is anticipated that he will take the field against the Rams for the NFC wild-card game. |
|||||
Dennis Gardeck (LB) | Ques Sun | Thumb - 06 / 01 / 22 | 1-1 | 1-1 | + - |
Gardeck is hindered by a thumb injury, and it is unclear if he will partake in Sunday's contest against the Seahawks. |
|||||
Tanner Vallejo (LB) | Out indefinitely | Illness - 04 / 01 / 22 | 1-1 | 1-1 | + - |
Vallejo has been added to the IR/COVID-19 list, and it has yet to be decided when he will return to action. |
-
INDIANAPOLIS COLTS
34 -
ARIZONA CARDINALS
23
Score
Prediction
-
Line History
Sports Interaction customers are placing their bets on:
time fav line total Opening 20 Dec 10:11am IND -2 -110 O +50 -108 Closing 26 Dec 1:14am IND -3 -110 O +48.5 -117 -
- Regular Season
- Playoffs
Colts Team Leaders
Touchdowns 20
Rushing 1811
Passing 3563
Receiving 88
Sacks 7
Interceptions 4
Touchdowns 18
Rushing 752
Passing 3787
Receiving 77
Sacks 11
Interceptions 4
Touchdowns Rushing Passing Did not qualify Receiving Sacks Interceptions Touchdowns 1
Rushing 28
Passing 137
Receiving 6
Sacks 1
Interceptions 0
-
- Regular Season
- Playoffs
Cardinals Team Leaders
Touchdowns 20
Rushing 1811
Passing 3563
Receiving 88
Sacks 7
Interceptions 4
Touchdowns 18
Rushing 752
Passing 3787
Receiving 77
Sacks 11
Interceptions 4
Touchdowns Rushing Passing Did not qualify Receiving Sacks Interceptions Touchdowns 1
Rushing 28
Passing 137
Receiving 6
Sacks 1
Interceptions 0
-
Weather
condition dome -
Injuries
Rock Ya-Sin (CB)
day-to-day Ankle - 09 / 01 / 22Mo Alie-Cox (TE)
Prob Sun Knee - 05 / 01 / 22George Odum (S)
Prob Sun Calf - 05 / 01 / 22Michael Pittman Jr. (WR)
Prob Sun Ribs - 05 / 01 / 22Chris Reed (G)
Prob Sun Illness - 05 / 01 / 22E.J. Speed (LB)
Prob Sun Hip - 05 / 01 / 22Xavier Rhodes (CB)
day-to-day Hamstring - 03 / 01 / 22Carson Wentz (QB)
Out indefinitely Illness - 28 / 12 / 21Marlon Mack (RB)
Out indefinitely Illness - 27 / 12 / 21Braden Smith (T)
Out indefinitely Illness - 27 / 12 / 21Greg Mabin (CB)
Out indefinitely Illness - 19 / 01 / 22Zach Allen (DE)
Prob Mon Ankle - 14 / 01 / 22Justin Pugh (OL)
Ques Mon Calf - 14 / 01 / 22Isaiah Simmons (LB)
Ques Mon Personal - 14 / 01 / 22Antonio Hamilton (CB)
Prob Mon Teeth - 14 / 01 / 22Jonathan Ward (RB)
Ques Mon Knee - 12 / 01 / 22Zach Allen (DE)
Ques Sun Ankle - 06 / 01 / 22Chase Edmonds (RB)
Prob Mon Ribs - 06 / 01 / 22Dennis Gardeck (LB)
Ques Sun Thumb - 06 / 01 / 22Tanner Vallejo (LB)
Out indefinitely Illness - 04 / 01 / 22Injuries
player (position) status ats*current o/u* notes Rock Ya-Sin (CB) day-to-day Ankle - 09 / 01 / 22 0-1 0-1 + - Ya-Sin is dealing with an ankle injury, and it is undecided if he will be active for postseason play.
Mo Alie-Cox (TE) Prob Sun Knee - 05 / 01 / 22 0-1 0-1 + - Alie-Cox is tending to a knee ailment, but it is not expected to affect his status against the Jaguars on Sunday.
George Odum (S) Prob Sun Calf - 05 / 01 / 22 0-1 0-1 + - Odum is expected to lace up against the Jaguars on Sunday despite a calf injury.
Michael Pittman Jr. (WR) Prob Sun Ribs - 05 / 01 / 22 0-1 0-1 + - Pittman Jr. is projected to take the field for Sunday's game versus the Jaguars despite a rib injury.
Chris Reed (G) Prob Sun Illness - 05 / 01 / 22 0-1 0-1 + - Reed is ailing from an illness, but it is projected that he will partake in Sunday's battle with the Jaguars.
E.J. Speed (LB) Prob Sun Hip - 05 / 01 / 22 0-1 0-1 + - Speed has a hip injury, but it is anticipated that he will be a participant in Sunday's matchup with the Jaguars.
Xavier Rhodes (CB) day-to-day Hamstring - 03 / 01 / 22 0-1 0-1 + - Rhodes is bothered by a hamstring injury, and it has yet to be established if he will be available for playoffs.
Carson Wentz (QB) Out indefinitely Illness - 28 / 12 / 21 1-1 0-2 + - Wentz has been shifted to the IR/COVID-19 list, and it is unknown when he will return.
Marlon Mack (RB) Out indefinitely Illness - 27 / 12 / 21 1-1 0-2 + - Mack has been designated to the IR/COVID-19 list, and a date for his return is unclear.
Braden Smith (T) Out indefinitely Illness - 27 / 12 / 21 1-1 0-2 + - Smith has been shuttled to the IR/COVID-19 list, and it is undecided when he will return to action.
player (position) status ats*current o/u* notes Greg Mabin (CB) Out indefinitely Illness - 19 / 01 / 22 0-0 0-0 + - Mabin has been added to the IR/COVID-19 list, and there is no timetable for return.
Zach Allen (DE) Prob Mon Ankle - 14 / 01 / 22 0-1 1-0 + - Allen has an ankle injury, but it is projected that he will take on the Rams in the NFC wild-card game.
Justin Pugh (OL) Ques Mon Calf - 14 / 01 / 22 0-1 1-0 + - Pugh is hobbled by a calf ailment, and it is undetermined if he will line up for the NFC wild-card game versus the Rams.
Isaiah Simmons (LB) Ques Mon Personal - 14 / 01 / 22 0-1 1-0 + - Simmons is tending to a personal matter, and it is unclear if he will be active for the NFC wild-card battle against the Rams.
Antonio Hamilton (CB) Prob Mon Teeth - 14 / 01 / 22 0-1 1-0 + - Hamilton is battling a tooth issue, but it is anticipated that he will face the Rams in the NFC wild-card game.
Jonathan Ward (RB) Ques Mon Knee - 12 / 01 / 22 0-1 1-0 + - Ward is managing a knee injury, and it is undecided if he will suit up for the NFC wild-card game against the Rams.
Zach Allen (DE) Ques Sun Ankle - 06 / 01 / 22 1-1 1-1 + - Allen is bothered by an ankle injury, and it is uncertain if he will take on the Seahawks on Sunday.
Chase Edmonds (RB) Prob Mon Ribs - 06 / 01 / 22 1-1 1-1 + - Edmonds has injuries to his ribs and toe, but it is anticipated that he will take the field against the Rams for the NFC wild-card game.
Dennis Gardeck (LB) Ques Sun Thumb - 06 / 01 / 22 1-1 1-1 + - Gardeck is hindered by a thumb injury, and it is unclear if he will partake in Sunday's contest against the Seahawks.
Tanner Vallejo (LB) Out indefinitely Illness - 04 / 01 / 22 1-1 1-1 + - Vallejo has been added to the IR/COVID-19 list, and it has yet to be decided when he will return to action.