Chargers vs. Chiefs Point Spread: NFL Week 2 Odds, Prediction

Payton Matthews | Updated Sep 15, 2022

Week 2 in the NFL kicks off in Kansas City with the Chiefs playing host to the Los Angeles Chargers.

September 15, 2022, 8:15 PM ET
Arrowhead Stadium
Pointspread +4 -110
Moneyline +171
Over / Under o +53


Betting Action


Pointspread -4 -110
Moneyline -206
Over / Under u +53


Betting Action


The first quick turnaround Thursday game of the season kicks off Week 2 as Justin Herbert and the Los Angeles Chargers visit Patrick Mahomes and the Kansas Chiefs. Kansas City is a 4-point favourite to win on the NFL odds, with a total of 54.5.

NFL Point Spread and Betting Analysis

This is the first regular-season Amazon Prime Video stream of the season and will feature Kirk Herbstreit (still does Saturday college football for ESPN) and the legendary Al Michaels in the booth. With all the money behind Amazon, I’d expect quite a few new graphics, gadgets, etc.

Herbert and Mahomes are two of the most exciting quarterbacks in the NFL, and their rivalry could be the league’s best for the next decade playing twice a regular season in the AFC West. Mahomes already has won an MVP, and Herbert has been a popular wager to win it this season.

The teams played two close games last season and each won on the road. In Kansas City in Week 3, it was 30-24 Chargers. Los Angeles coach Brandon Staley opted to go for it on fourth down late rather than try a 48-yard field goal and it worked as it eventually led to the winning TD. Herbert had four TD passes and Mahomes three but two picks.

The Chargers are 3-1-1 against the spread in the past five meetings.

Los Angeles Chargers

The Chargers beat the visiting Raiders 24-19 on Sunday but lost Pro Bowl receiver Keenan Allen with a hamstring injury, and he’s not likely to play in the quick turnaround. He had four catches for 66 yards in the win and 106 catches for 1,138 yards and six scores last year. Joshua Palmer likely would take his spot. Tight end Donald Parham is also iffy for Thursday with a hamstring injury. He sat out Sunday. So did big-ticket free-agent addition and cornerback JC Jackson, who isn’t likely for Thursday, either. The team’s other big offseason acquisition, former NFL Defensive Player of the Year Khalil Mack, had three sacks in Sunday’s win. Herbert threw for 279 yards and three scores. The Chargers are 1-5 ATS in their past six after a victory.

Kansas City Chiefs

There’s no universe where the Chiefs aren’t going to miss traded All-Pro receiver Tyreek Hill at some point, but they didn’t on Sunday in smashing the Cardinals 44-21 in Arizona. Mahomes was fantastic in completing 30 of 39 for 360 yards and five scores. The Chiefs lost cornerback Trent McDuffie with a hamstring injury, and an ankle injury to kicker Harrison Butker forced Kansas City to use a safety, Justin Reid, to kick two extra points and to kick off. Coach Andy Reid blamed the injuries on the turf. McDuffie definitely is out Thursday and Butker probably is. Matt Ammendola, who was 13-for-19 on field goals last year with the Jets, would take Butker’s spot. The Chiefs are 6-1 ATS in their past seven at home.

NFL Prediction: Who Will Win Chargers vs. Chiefs?