Cardinals vs. Rams Point Spread: NFL Wildcard Odds, Prediction

Jordan Ramsay | Updated Jan 13, 2022

The NFC West will be on display Monday night in the wild-card round when the L.A. Rams play host to the Arizona Cardinals.

January 17, 2022, 8:15 PM ET
SoFi Stadium
L.A. Rams
Pointspread +3.5 -110
Moneyline +158
Over / Under o +50


Betting Action


Pointspread -3.5 -110
Moneyline -193
Over / Under u +50


Betting Action


The NFC West title came down to the final week of the regular-season, but the L.A. Rams eventually came out on top over the Arizona Cardinals.  It didn’t look good for the Rams after they dropped a 27-24 overtime decision against San Francisco, but the Cardinals’ 38-30 loss to Seattle clinched the division title for L.A.

The Rams are 4-point favourites to win on the NFL odds, with a total of 49.5.

NFL Point Spread and Betting Analysis

The road team came out on top in both meetings between these teams this season.  Kyler Murray threw for 268 yards and two touchdowns in Arizona’s 37-20 Week 4 win.  Matthew Stafford tossed for 287 yards and three TDs in L.A.’s Week 14 win.  A little over 60 per cent of Sports Interaction bettors are backing the Cardinals on Monday, while it’s around a 60/40 split favouring the Over.

Arizona was much more comfortable on the road this season, going 8-1 outside of State Farm Stadium compared to 3-5 at home.  They were 10-7 against the spread overall, but they’ve been a brutal cover option against the Rams, going 1-8-1 ATS in their last 10 against L.A.  The total has gone Over in eight of the Cardinals’ last 12 games played in January.

The Rams have dominated this head-to-head series, winning nine of their last 10 games against Arizona.  L.A. wasn’t a great cover option this year, going 8-9 ATS overall and 4-4 ATS at home.  The total has gone Under in four of the Rams’ last five home games.

Arizona Cardinals

Arizona is just the ninth team in NFL history to win eight road games in a season, although there was an extra game added this year.  Of course, one of those road wins came at SoFi Stadium against the Rams early in the year.  The Cardinals rushed for 216 yards in that game, including 120 by Chase Edmonds.  Arizona averaged 122 rushing yards per game during the regular-season and their 23 rushing TDs was third-most in the NFL.  Murray, Edmonds and James Conner were a three-pronged attack, combining for 1,767 rushing yards.  Murray added 3,787 passing yards with 24 TDs to 10 interceptions.

The Cardinals defence could get a huge boost with the possible return of J.J. Watt, who has missed the last two months with a shoulder injury.  Watt’s status won’t be determined until later in the week, but his importance can’t be overlooked.  Arizona is 7-0 with Watt in the lineup this year and 4-6 with him out.  Edmonds and Conner are each dealing with rib injuries, but both running backs are expected to play this week.

Los Angeles Rams

Matthew Stafford has played exactly three playoff games in his career and has won exactly zero.  But, that has more to do with playing in Detroit than Stafford, so the veteran quarterback has his first real chance to win a playoff game this week.  Stafford had a big year overall, setting a new Rams franchise record with 4,886 passing yards and finishing second to Tom Brady with 41 TD passes.  The big concern is Stafford’s play to end the year.  Since Week 9, he’s thrown a league-high 11 interceptions, including four pick-sixes.

Still, Stafford will have plenty of receiving weapons to target, particularly Cooper Kupp.  Kupp had a career-year and became just the fourth player in NFL history to lead the league in receptions (145), receiving yards (1,947) and receiving TDs (16).  Running back Cam Akers is a surprise returnee to the lineup.  Akers, who torn his Achilles in July and was thought to be done for the year, returned last week, running the ball five times and catching three passes.

NFL Prediction: Who Will Win Cardinals vs. Rams?