Cardinals vs. 49ers Point Spread: NFL Week 1 Odds, Prediction

Sports Interaction Staff | Updated Sep 09, 2020

49ers vs. Cardinals, 2020

The 49ers are getting the respect a team coming off a Super Bowl appearance deserves, but teams coming off a Super Bowl loss are 2-13 ATS and 4-11 SU in Week 1.

Arizona
8-8
AT
September 13, 2020, 4:25 PM ET
Levi's Stadium
Pointspread +7 -117
Moneyline +244
Over / Under o +48.5

56%

Betting Action

44%

Pointspread -7 -103
Moneyline -296
Over / Under u +48.5

56%

Betting Action

44%

Sunday’s season opener against the Cardinals marks the first time we’ll see the 49ers since an epic third quarter collapse cost them Super Bowl LIV in February.

Favoured by a touchdown and listed at -295 on the moneyline, the 49ers are trying to avoid a Super Bowl hangover, while the Cardinals come into this season hoping to improve upon Kyler Murray’s impressive 2019 rookie season.  The Cardinals are 7-point underdogs and +243 on the moneyline.

NFL Point Spread and Betting Analysis

The 49ers are getting the respect a team coming off a Super Bowl appearance deserves, but bettors should be cautious of relying too heavily on that.  You only need to look at the LA Rams from last season for a Super Bowl hangover cautionary tale.  In the last 18 years (if you don’t count the New England Patriots), teams coming off a Super Bowl loss are 2-13 ATS and 4-11 SU in Week 1.  The 49ers offense has also started slow in the past, with the under going 6-0 in their last six season openers.

Kyler Murray only continued to get better as last season progressed, helping the Cardinals finish the season 7-3-2 ATS in their final 12 games.  Although losing both games against the 49ers last year, the Cardinals had solid outings scoring 25 then 26 points in those games.

Arizona Cardinals

As Kyler Murray continues to become more comfortable with Kilff Kingsbury’s high-tempo offense, we should see him take a big step forward this year.  This big question for the Cardinals is on the defensive side.  Last year the Cardinals defense allowed a league-worst 402 yards per game.  First round draft pick Isaiah Simmons and free agent signing Jordan Phillips should plug some holes on the defensive side of the ball, but will it be enough to stop a 49ers team that rushed for over 150 yards per game last season?

San Francisco 49ers

Despite losing All-Pro DT DeForest Buckner in the off-season, most of the key cogs for the 49ers are still around and the addition of Trent Williams improves the offensive line.  The biggest concern for San Francisco right now is the depth at wide receiver with Tavon Austin, Travis Benjamin and Jalen Hurd all out in Week 1, while Richie James and Brandon Aiyuk are listed as questionable.  The 49ers won both games against the Cardinals last season by slim margins (28-25 in Arizona and 36-26 in San Francisco) so expect this game to be closer than anticipated, this early in the season.

Who Will Win Cardinals vs. 49ers?

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