Bills vs. Saints Point Spread: NFL Week 12 Odds, Prediction

Jordan Ramsay | Updated Nov 23, 2021

When the Saints and Bills meet in New Orleans on Thursday, both teams will be looking to get back in the win column following losses last week.

November 25, 2021, 8:20 PM ET
Mercedes-Benz Superdome
Pointspread -7.5 -110
Moneyline -335
Over / Under o +45.5


Betting Action


Pointspread +7.5 -110
Moneyline +270
Over / Under u +45.5


Betting Action


Buffalo was embarrassed at home in Week 11, falling to the Colts in a 41-15 blowout loss.  New Orleans comes into Week 12 off a 40-29 loss in Philadelphia.

The Bills are 4.5-point favourites to win on the NFL odds, with a total of 46.0.

NFL Point Spread and Betting Analysis

These teams last met in 2017, with the Saints winning 47-10 in Buffalo.  It’s the Bills that are getting the love from Sports Interaction bettors in this one though, as 82 per cent of action favours Buffalo.  About 80 per cent of bettors are taking the Over.

With last week’s loss, the Bills now trail New England for top spot in the AFC East.  Buffalo is struggling against contenders as they’re 5-1 straight up and 4-1-1 against the spread versus teams below .500, while they’re 1-3 SU and ATS versus teams with winning records.  The total has gone Over in four of their last six games.

New Orleans hasn’t been able to gain much momentum this season.  They’re 2-2 SU at home and 3-3 SU on the road.  The Saints are 5-5 ATS overall, covering in half of their four home games.  The total has gone Over in six of the Saints’ last seven games.

Buffalo Bills

Buffalo’s defence was absolutely torched by Jonathan Taylor last week, who rushed for 185 yards and four touchdowns and also added a fifth TD receiving.  The Bills didn’t help themselves as they turned the ball over four times and failed to create any turnovers.  Josh Allen finished with 209 passing yards, two touchdowns and two interceptions.  Allen is 17-17 in his career when he has committed a turnover.  Stefon Diggs caught both TD passes, finishing with 23 yards on four catches.  Kicker Tyler Bass missed both of his field goal attempts.

Buffalo has remained relatively healthy this season.  Only two players were listed on the Monday injury report.  Linebacker Tremaine Edmunds, who was out last week with a hamstring injury, was listed as a full participant at practice and will likely return to the lineup against New Orleans.  Receiver Cole Beasley was limited at practice as he continues to deal with a rib injury.  Beasley has played through the injury and is expected to be in the lineup on Thursday.

New Orleans Saints

The Saints have stayed competitive since losing starting quarterback Jameis Winston to a season-ending knee injury, but they haven’t been able to close out games and have dropped two two-point games in the last three weeks.  Trevor Siemian threw for 213 yards and three touchdowns in last week’s blowout loss against the Eagles, but he was also picked off twice.  Running back Alvin Kamara (knee) and starting offensive tackles Terron Armstead (knee/shoulder) and Ryan Ramczyk (knee) all missed the game.  It’s uncertain if any of the three players will be ready for Thursday.  If Kamara remains out, expect Mark Ingram Jr. to get more touches.  Ingram finished with 88 yards on 16 carries last week.

NFL Prediction: Who Will Win Bills vs. Saints?