Bills vs. Colts Point Spread: NFL Week 7 Odds, Prediction

Jeremy Perry | Updated Oct 16, 2018

lesean mccoy bills

The Bills may have to lean heavily again on a rush attack lead by LeSean McCoy that has produced just 597 total yards on the ground on 3.6 yards per carry.

October 21, 2018, 1:00 PM ET
Lucas Oil Stadium
Pointspread +7 -105
Moneyline +250
Over / Under o +43.5


Betting Action


Pointspread -7 -115
Moneyline -310
Over / Under u +43.5


Betting Action


The good news for the Indianapolis Colts is that they’ve begun to hit their offensive stride. The bad news is, not even a sudden scoring surge has moved them back into the win column as they bring a four-game losing streak into Sunday’s encounter with visiting Buffalo. The Colts have averaged better than 30 points over their previous three games but have fallen short in all three, having surrendered a whopping 39 points per game in that span.

NFL Point Spread and Betting Analysis

It has been nearly four years since Indy has been favoured by a touchdown or more – but when the Colts have given away that many points, they’ve been a really good cover option, having gone 6-1-1 ATS in their previous eight games when giving away seven or more points. The Bills put together their best game of the season away from Buffalo with a 27-6 victory over Minnesota, but scored just 19 total points in their past four road games aside from that one.

Not surprisingly, the Bills enter the weekend having been one of the more reliable under options on the road, having gone below the number in 10 of their previous 14 games outside Buffalo. The Colts have cashed the over in consecutive home games after reeling off a streak of five consecutive unders, but are 4-11 O/U in their previous 15 contests at Lucas Oil Stadium. And the under has come through in six of the past seven meetings between the teams.

Buffalo Bills

The Bills are already struggling mightily on offence, averaging a league-low 12.7 points per game – and things are even more dire with word that rookie quarterback Josh Allen will miss up to a month with an elbow injury. Look for the Bills to lean even more heavily on a rush attack lead by LeSean McCoy that has produced just 597 total yards on the ground on 3.6 yards per carry. The Colts have been surprisingly stingy against the run in 2018, limiting opponents to 3.7 yards per tote.

Indianapolis Colts

While the Colts’ defence hopes for a reprieve against the Bills’ woeful pass attack, they’d love nothing more than to see Andrew Luck continue his solid play. Luck has thrown for more than 1,100 yards over the previous three weeks while tossing 11 touchdown passes. But Luck has also thrown five interceptions over the past two weeks, giving him eight for the season – tied with Case Keenum, Blake Bortles and Derek Carr for the league lead.

Bills vs. Colts Prediction