49ers vs. Saints Point Spread: NFL Week 10 Odds, Prediction

Nik Kowalski | Updated Nov 13, 2020

Michael Thomas and Drew Brees, Saints, 2019

The Saints enter this game with the 49ers on a five-game winning steak. That's tops in the NFC.

November 15, 2020, 4:25 PM ET
Mercedes-Benz Superdome
Pointspread +9.5 -110
Moneyline +360
Over / Under o +49.5


Betting Action


Pointspread -9.5 -110
Moneyline -472
Over / Under u +49.5


Betting Action


Week 9 was a tale of two opposites for the 6-2 New Orleans Saints and 4-5 San Francisco 49ers.

The Saints showed they still run the NFC South, crushing the Tampa Bay Buccaneers 38-3 on Sunday Night Football where the hampered 49ers took an ugly 34-17 loss to Green Bay.

Next up for San Fran is a trip to Louisiana to face the Saints and their five-game win streak.

NFL Point Spread and Betting Analysis

Points have ruled when these clubs go head-to-head, with the over hitting on six of their last seven. Further, New Orleans has seen the over connect on seven of their last eight, and four of their last five at home.

With Drew Brees leading the league’s fourth-highest scoring offence, the Saints should hold their end of the bargain but questions remain around Nick Mullens’ offence. The 49ers are 18th in points per game, and were stuck at three points last week until some late stat-padding.

Mullens will remain the starter in place of an injured Jimmy Garoppolo, so oddsmakers have the Saints listed at -10 and the total 49.

San Francisco 49ers

The most important addition to the 49ers lineup this week could be Raheem Mostert. The highly-graded running back was averaging 5.9 yards per carry before an ankle injury in Week 6. If he does suit up, Mostert will have to work for every yard as the Saints possess the NFL’s second-best run defence averaging 80.2 yards per game.

Receivers Deebo Samuel and Brandon Aiyuk, as well as All-Pro left tackle Trent Williams are also looking to return after missing last week on the reserve/COVID-19 list. But if they can’t go, Richie James can after he broke out for nine catches for 184 yards and a touchdown – San Fran’s lone bright spot in Week 9.

The 49ers currently have 14 players making over $79 million on their IR, both leading the NFL.

New Orleans Saints

Sure, the firepower of Drew Brees, Alvin Kamara, Michael Thomas, and even Taysom Hill have played a large role in the Saints 6-2 record and top-five offence, but it’s the finer statistics that make this well-rounded group tick.

New Orleans’ offence is first in the NFL with a 51.4 third down conversion rate, third in sack percentage at 3.32 per cent of plays, and fourth in time of possession at 31:52 per game.

All of which were heavily on display last Sunday, with the Saints going nine for 14 on third down, getting sacked once, and holding the ball for 40:04 against Tom Brady’s Buccaneers. Then there’s the Saints’ pass defence having the game of their season, holding Brady to 209 yards and three points while intercepting him three times. Breaking: the Saints are still great.

NFL Prediction: Who Will Win 49ers vs. Saints?