49ers vs. Panthers Point Spread: NFL Week 5 Odds, Prediction

Daniel Coyle | Updated Oct 06, 2022

The San Francisco 49ers continue the search for their first road win of the season when they visit the Carolina Panthers on Sunday in NFL Week 5 action.

October 09, 2022, 4:05 PM ET
Bank of America Stadium
Pointspread -6 -110
Moneyline -264
Over / Under o +40


Betting Action


Pointspread +6 -110
Moneyline +219
Over / Under u +40


Betting Action


The 49ers hit the road on a high after extending their recent dominance over the rival Los Angeles Rams with a decisive 24-9 victory on Monday Night Football that evens their straight up record on the season at 2-2-0. The Panthers find themselves on the rebound after dropping a 26-16 decision to the visiting Arizona Cardinals last week, which marked the 10th outright defeat in 11 contests since last November.

Buoyed by the backing of 74 per cent of sports bettors, the Niners have vaulted to 6.5-point favourites since opening as 3-point chalk, and now sport improving -113 odds of covering that spread. The total has held steady since opening at 39, with the OVER attracting 64 per cent of the betting action.

NFL Point Spread and Betting Analysis

Sunday afternoon’s matchup at Bank of America Stadium marks the first meeting between these NFC rivals since 2019, and the 49ers’ first visit to Carolina since September 2016. The 49ers powered to an easy 51-13 victory when they last faced the Panthers three years ago. However, the Panthers have otherwise dominated in head-to-head action, claiming victory in 10 of 14 over clashes since 1998, and going 5-2-0 straight up and 6-1-0 against the spread in their past seven dates on home turf.

Recent dates involving these teams have tended to be high scoring, with the total topping 70 in two of their past three, extending a steady run for the OVER, which has gone 14-5-0 in their past 19 meetings.

San Francisco 49ers

It has been a tale of two teams in San Francisco so far this season. The 49ers have carried over their strong play on home turf that marked the end of their 2021 campaign, extending their current home win streak with decisive victories over NFC West rivals Seattle and Los Angeles. However, things have not gone so well on the road. The Niners have opened their road schedule with weak performances in both Chicago and Denver, where they lost outright as betting favourites. A lack of steady offensive production has not helped the 49ers on the road, where they have averaged just nine points per game during a 0-3-0 overall slide, and have failed to top 17 points in five of their past seven.

However, with Jimmy Garoppolo quickly settling back into his familiar role as starting quarterback, the Niners could be poised for a breakthrough on the road. “Jimmy G” is coming off an impressive performance in Monday night’s win over the Rams, tossing for 239 yards, and has now found the end zone in each of his three appearances since taking over the reigns from the injured Trey Lance.

Carolina Panthers

After snapping a nine-game slide with a 22-14 win over New Orleans two weeks ago, the Panthers returned to familiar form in last week’s loss to Arizona. While the team rode the momentum gained from their win over the Saints to an early 10-3 lead, they quickly faded after halftime in the face of a stout Cardinals defence, which limited Carolina to just 16 total yards over their first four possessions of the second half. The Panthers also had no answer for the Cardinals offence, which scored on each of their first four second-quarter possessions.

Overall, the Panthers mustered just 220 yards and 11 first downs while controlling the ball for just 21:25. And in the wake of that brutal performance, the Panthers now rank dead last in the NFL with just 262.3 total yards per game. Baker Mayfield’s continued struggles in his new job as Panthers starting quarterback have not helped matters. Indeed, his performance against Arizona was simply disastrous. Mayfield went 22-for-36 for just 197 yards, one garbage-time score and two picks. However, on the bright side, Mayfield has now tossed for at least one touchdown in 11 straight appearances.

NFL Prediction: Who Will Win 49ers vs. Panthers?