Elimination is creeping in toward both the San Francisco 49ers and Miami Dolphins when they clash over in the Sunshine State on Sunday.
Both clubs suffered defeats last week that had tremendous impacts on playoff odds. Miami’s 20-12 defeat at Houston kept the Dolphins two games back behind the final AFC Wild-Card spot, while the 49ers’ 12-6 loss on Thursday Night Football last week dropped them 6-8 as well and in sole possession of last in the NFC West.
Injuries have no doubt plagued both the 49ers and Dolphins during the 2024–25 season, but squandering last week’s opportunities sealed the disappointing fates for each team. Miami and the 49ers were both legitimate Super Bowl contenders last season and to an extent this season. Now, they battle one another in Week 16 to solidify one team finishing below .500.
Kickoff at Hard Rock Stadium goes at 4:25 p.m. EST, with the Dolphins currently a one-point favourite on home field and the total at 44.5 on the NFL odds.
NFL Point Spread and Betting Analysis
Both San Francisco and Miami share identical 6-8 records, and 5-9 records against the spread. The 49ers are 1-5 ATS on the road this season but Miami’s not much better at home, going 2-5 ATS through seven home outings. Five consecutive Dolphins home games have gone over the total, as have five of the last six 49ers-Dolphins matchups.
Offensive struggles, mainly due to key injuries, have been at the centre of both teams problems this season. The 49ers rank 15th with 22.4 points per contest this season and the Dolphins 24th with 19.7. For reference, the 49ers and Dolphins finished second and third in points scored last season respectively. Miami’s been scoring at home this season though, putting a minimum of 32 points in each of their last three home outings.
San Francisco 49ers
Some extra time to prepare, and Miami sunshine should do the 49ers offence some good. Or at least that’s the plan after last week’s 12-6 defeat to L.A. in the heavy rain. As bodies start to return for the 49ers defence, others are departing — in new ways too! The defence got a big boost last week when linebacker Dre Geenlaw returned from a torn Achilles suffered in last year’s Super Bowl, but now De’Vondre Campbell is gone from the linebacker corps. The 49ers suspended Campbell for at least the next three games after he refused to play last week.
Running back Isaac Guerendo, the 49ers third-string running back turned starter missed Wednesday’s practice with foot and hamstring issues. If Guerendo can’t go, Patrick Taylor Jr. and Israel Abanikanda would split backfield duties. Defensive end Nick Bosa (hip, oblique) is also on the team’s injury report now, which is the latest in a disastrous 49ers season.
Miami Dolphins
The Dolphins again failed to rise to their competition’s level last week, losing at Houston 20-12 and falling to 1-6 when facing teams with a .500 record or better. With starting tackles starting tackles Terron Armstead (knee) and Kendall Lamm (back) injured, Tua Tagovailoa and the Dolphins offence felt the effects. The result was four Dolphins turnovers at the hands of Tua, 196 passing yards, and just two catches for 36 yards from Tyreek Hill. Armstead, Lamm, and Hill (rest/wrist) all did not practice Wednesday.
The Dolphins can’t function without Tagovailoa, something that’s derailed their two past seasons initially filled with optimism. But when Tagovailoa’s healthy, Miami still can’t seem to get over the hump against the NFL’s best. And despite a 6-8 record, the 49ers still have a ton of weapons that make them a dangerous NFL team and a problem for Miami.
NFL Prediction: Who Will Win 49ers vs. Dolphins?
Line History
Sports Interaction customers are placing their bets on:
time | fav | line | total |
---|---|---|---|
Opening 16 Dec 12:44am | - | - | O +46.5 -105 |
Closing 22 Dec 11:34pm | - | - | O +41.5 -115 |
- Regular Season
49ers Team Leaders
Touchdowns |
6 |
Rushing |
789 |
Passing |
3864 |
Receiving |
77 |
Sacks |
8.5 |
Interceptions |
2 |
Touchdowns |
12 |
Rushing |
907 |
Passing |
2867 |
Receiving |
81 |
Sacks |
10 |
Interceptions |
3 |
- Regular Season
Dolphins Team Leaders
Touchdowns |
6 |
Rushing |
789 |
Passing |
3864 |
Receiving |
77 |
Sacks |
8.5 |
Interceptions |
2 |
Touchdowns |
12 |
Rushing |
907 |
Passing |
2867 |
Receiving |
81 |
Sacks |
10 |
Interceptions |
3 |
Weather

temp | 73 |
condition | partly-cloudy |
wind | Northeast 12mph |
Injuries
Ji'ayir Brown (S)
Deommodore Lenoir (DB)
Colton McKivitz (OL)
Ricky Pearsall (WR)
Deebo Samuel Sr. (WR)
Isaac Yiadom (CB)
Demetrius Flannigan-Fowles (LB)
Leonard Floyd (DL)
Brock Purdy (QB)
Charvarius Ward (CB)
Dee Eskridge (WR)
Jake Bailey (P)
Tyreek Hill (WR)
Jevon Holland (S)
Jordan Poyer (S)
Kendall Fuller (CB)
Tyreek Hill (WR)
Alec Ingold (FB)
Jordan Poyer (S)
Tua Tagovailoa (QB)
Injuries
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Ji'ayir Brown (S) | Questionable | Ankle - 02 / 01 / 25 | 0-1 | 1-0 | + - |
Brown is dealing with an ankle injury, and it is unclear if he will be available against the Cardinals on Sunday, January 5th. |
|||||
Deommodore Lenoir (DB) | Out | Shoulder - 02 / 01 / 25 | 0-1 | 1-0 | + - |
Lenoir is battling with a shoulder injury, and he is unlikely to be active against the Cardinals on Sunday, January 5th. |
|||||
Colton McKivitz (OL) | Questionable | Knee - 02 / 01 / 25 | 0-1 | 1-0 | + - |
McKivitz is is hampered by a knee injury, and it is uncertain if he will play against the Cardinals on Sunday, January 5th. |
|||||
Ricky Pearsall (WR) | Questionable | Illness - 02 / 01 / 25 | 0-1 | 1-0 | + - |
Pearsall is dealing with an illness, and it is unclear if he will be available against the Cardinals on Sunday, January 5th. |
|||||
Deebo Samuel Sr. (WR) | Out | Ribs - 02 / 01 / 25 | 0-1 | 1-0 | + - |
Samuel is nursing a ribs injury, and he is unlikely to be active against the Cardinals on Sunday, January 5th. |
|||||
Isaac Yiadom (CB) | Questionable | Pelvis - 02 / 01 / 25 | 0-1 | 1-0 | + - |
Yiadom is nursing a pelvis injury, and it is unclear if he will play against the Cardinals, on Sunday, January 5th. |
|||||
Demetrius Flannigan-Fowles (LB) | Out indefinitely | Calf - 31 / 12 / 24 | 0-2 | 2-0 | + - |
Flannigan-Fowles has been placed on injured reserve with a calf injury, and it is unknown how long he will be debilitated. |
|||||
Leonard Floyd (DL) | Questionable | Shoulder - 31 / 12 / 24 | 0-2 | 2-0 | + - |
Floyd is battling a shoulder injury, and it is unclear if he will be active against the Cardinals on Sunday, January 5th. |
|||||
Brock Purdy (QB) | Out | Elbow - 31 / 12 / 24 | 0-2 | 2-0 | + - |
Purdy is nursing an elbow injury, and he is not expected to dress against the Cardinals on Sunday, January 5th. |
|||||
Charvarius Ward (CB) | Questionable | Personal - 29 / 12 / 24 | 0-2 | 2-0 | + - |
Ward is dealing with a personal matter, and it is uncertain if he will participate against the Cardinals on Sunday, January 5th. |
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Dee Eskridge (WR) | Questionable | Finger - 04 / 01 / 25 | 1-0 | 0-1 | + - |
Eskridge is managing a finger injury, and it has yet to be established if he will play against the Jets on Sunday, January 5th. |
|||||
Jake Bailey (P) | Questionable | Back - 02 / 01 / 25 | 1-0 | 0-1 | + - |
Bailey is managing a back injury, and it is uncertain if he will suit up against the Jets on Sunday, January 5th. |
|||||
Tyreek Hill (WR) | Questionable | Wrist - 02 / 01 / 25 | 1-0 | 0-1 | + - |
Hill is nursing a wrist injury, and it is unclear if he will suit up against the Jets on Sunday, January 5th. |
|||||
Jevon Holland (S) | Questionable | Wrist - 02 / 01 / 25 | 1-0 | 0-1 | + - |
Holland is nursing a wrist injury, and it is unclear if he will suit up against the Jets on Sunday, January 5th. |
|||||
Jordan Poyer (S) | Questionable | Knee - 02 / 01 / 25 | 1-0 | 0-1 | + - |
Poyer is hobbled by a knee injury, and it remains to be seen if he will return to action against the Jets on Sunday, January 5th. |
|||||
Kendall Fuller (CB) | out for season | Knee - 25 / 12 / 24 | 2-0 | 1-1 | + - |
Fuller is placed on the injured reserve list with a knee injury, and he is projected to miss the remainder of the season. |
|||||
Tyreek Hill (WR) | Questionable | Wrist - 25 / 12 / 24 | 2-0 | 1-1 | + - |
Hill is bothered by a wrist injury, and it is uncertain if he will play against the Browns on Sunday, December 29th. |
|||||
Alec Ingold (FB) | Questionable | Ankle - 25 / 12 / 24 | 2-0 | 1-1 | + - |
Ingold is bothered by an ankle injury, and it is unclear if he will face Jets on Sunday, January 5th. |
|||||
Jordan Poyer (S) | Questionable | Knee - 25 / 12 / 24 | 2-0 | 1-1 | + - |
Poyer is bothered by a knee injury, and it has yet to be established if he will play against the Browns on Sunday, December 29th. |
|||||
Tua Tagovailoa (QB) | Doubtful | Hip - 25 / 12 / 24 | 2-0 | 1-1 | + - |
Tagovailoa is bothered by a hip injury, and he is not expected to face the Jets on Sunday, January 5th. |
-
Line History
Sports Interaction customers are placing their bets on:
time fav line total Opening 16 Dec 12:44am - - O +46.5 -105 Closing 22 Dec 11:34pm - - O +41.5 -115 -
- Regular Season
49ers Team Leaders
Touchdowns 6
Rushing 789
Passing 3864
Receiving 77
Sacks 8.5
Interceptions 2
Touchdowns 12
Rushing 907
Passing 2867
Receiving 81
Sacks 10
Interceptions 3
-
- Regular Season
Dolphins Team Leaders
Touchdowns 6
Rushing 789
Passing 3864
Receiving 77
Sacks 8.5
Interceptions 2
Touchdowns 12
Rushing 907
Passing 2867
Receiving 81
Sacks 10
Interceptions 3
-
Weather
temp 73 condition partly-cloudy wind Northeast 12mph -
Injuries
Ji'ayir Brown (S)
Questionable Ankle - 02 / 01 / 25Deommodore Lenoir (DB)
Out Shoulder - 02 / 01 / 25Colton McKivitz (OL)
Questionable Knee - 02 / 01 / 25Ricky Pearsall (WR)
Questionable Illness - 02 / 01 / 25Deebo Samuel Sr. (WR)
Out Ribs - 02 / 01 / 25Isaac Yiadom (CB)
Questionable Pelvis - 02 / 01 / 25Demetrius Flannigan-Fowles (LB)
Out indefinitely Calf - 31 / 12 / 24Leonard Floyd (DL)
Questionable Shoulder - 31 / 12 / 24Brock Purdy (QB)
Out Elbow - 31 / 12 / 24Charvarius Ward (CB)
Questionable Personal - 29 / 12 / 24Dee Eskridge (WR)
Questionable Finger - 04 / 01 / 25Jake Bailey (P)
Questionable Back - 02 / 01 / 25Tyreek Hill (WR)
Questionable Wrist - 02 / 01 / 25Jevon Holland (S)
Questionable Wrist - 02 / 01 / 25Jordan Poyer (S)
Questionable Knee - 02 / 01 / 25Kendall Fuller (CB)
out for season Knee - 25 / 12 / 24Tyreek Hill (WR)
Questionable Wrist - 25 / 12 / 24Alec Ingold (FB)
Questionable Ankle - 25 / 12 / 24Jordan Poyer (S)
Questionable Knee - 25 / 12 / 24Tua Tagovailoa (QB)
Doubtful Hip - 25 / 12 / 24Injuries
player (position) status ats*current o/u* notes Ji'ayir Brown (S) Questionable Ankle - 02 / 01 / 25 0-1 1-0 + - Brown is dealing with an ankle injury, and it is unclear if he will be available against the Cardinals on Sunday, January 5th.
Deommodore Lenoir (DB) Out Shoulder - 02 / 01 / 25 0-1 1-0 + - Lenoir is battling with a shoulder injury, and he is unlikely to be active against the Cardinals on Sunday, January 5th.
Colton McKivitz (OL) Questionable Knee - 02 / 01 / 25 0-1 1-0 + - McKivitz is is hampered by a knee injury, and it is uncertain if he will play against the Cardinals on Sunday, January 5th.
Ricky Pearsall (WR) Questionable Illness - 02 / 01 / 25 0-1 1-0 + - Pearsall is dealing with an illness, and it is unclear if he will be available against the Cardinals on Sunday, January 5th.
Deebo Samuel Sr. (WR) Out Ribs - 02 / 01 / 25 0-1 1-0 + - Samuel is nursing a ribs injury, and he is unlikely to be active against the Cardinals on Sunday, January 5th.
Isaac Yiadom (CB) Questionable Pelvis - 02 / 01 / 25 0-1 1-0 + - Yiadom is nursing a pelvis injury, and it is unclear if he will play against the Cardinals, on Sunday, January 5th.
Demetrius Flannigan-Fowles (LB) Out indefinitely Calf - 31 / 12 / 24 0-2 2-0 + - Flannigan-Fowles has been placed on injured reserve with a calf injury, and it is unknown how long he will be debilitated.
Leonard Floyd (DL) Questionable Shoulder - 31 / 12 / 24 0-2 2-0 + - Floyd is battling a shoulder injury, and it is unclear if he will be active against the Cardinals on Sunday, January 5th.
Brock Purdy (QB) Out Elbow - 31 / 12 / 24 0-2 2-0 + - Purdy is nursing an elbow injury, and he is not expected to dress against the Cardinals on Sunday, January 5th.
Charvarius Ward (CB) Questionable Personal - 29 / 12 / 24 0-2 2-0 + - Ward is dealing with a personal matter, and it is uncertain if he will participate against the Cardinals on Sunday, January 5th.
player (position) status ats*current o/u* notes Dee Eskridge (WR) Questionable Finger - 04 / 01 / 25 1-0 0-1 + - Eskridge is managing a finger injury, and it has yet to be established if he will play against the Jets on Sunday, January 5th.
Jake Bailey (P) Questionable Back - 02 / 01 / 25 1-0 0-1 + - Bailey is managing a back injury, and it is uncertain if he will suit up against the Jets on Sunday, January 5th.
Tyreek Hill (WR) Questionable Wrist - 02 / 01 / 25 1-0 0-1 + - Hill is nursing a wrist injury, and it is unclear if he will suit up against the Jets on Sunday, January 5th.
Jevon Holland (S) Questionable Wrist - 02 / 01 / 25 1-0 0-1 + - Holland is nursing a wrist injury, and it is unclear if he will suit up against the Jets on Sunday, January 5th.
Jordan Poyer (S) Questionable Knee - 02 / 01 / 25 1-0 0-1 + - Poyer is hobbled by a knee injury, and it remains to be seen if he will return to action against the Jets on Sunday, January 5th.
Kendall Fuller (CB) out for season Knee - 25 / 12 / 24 2-0 1-1 + - Fuller is placed on the injured reserve list with a knee injury, and he is projected to miss the remainder of the season.
Tyreek Hill (WR) Questionable Wrist - 25 / 12 / 24 2-0 1-1 + - Hill is bothered by a wrist injury, and it is uncertain if he will play against the Browns on Sunday, December 29th.
Alec Ingold (FB) Questionable Ankle - 25 / 12 / 24 2-0 1-1 + - Ingold is bothered by an ankle injury, and it is unclear if he will face Jets on Sunday, January 5th.
Jordan Poyer (S) Questionable Knee - 25 / 12 / 24 2-0 1-1 + - Poyer is bothered by a knee injury, and it has yet to be established if he will play against the Browns on Sunday, December 29th.
Tua Tagovailoa (QB) Doubtful Hip - 25 / 12 / 24 2-0 1-1 + - Tagovailoa is bothered by a hip injury, and he is not expected to face the Jets on Sunday, January 5th.