Steelers vs. Patriots Prediction, Odds & Stats - September 21, 2025

Final Score
Pittsburgh
Steelers
New England
Patriots
21
14
Pittsburgh Steelers
New England Patriots
Scoreboard 1 2 3 4 Odds
Pittsburgh Steelers 9-7 7 7 0 7 +44.5
New England Patriots 13-3 0 7 0 7 +1

Latest Encounters

Date Result Competition Stats Recap
12/28/25
Pittsburgh Steelers PIT ( 9-7 )
Cleveland Browns CLE ( 4-12 )
6   -   13
AFC North
12/28/25
New England Patriots NE ( 13-3 )
N.Y. Jets Jets NYJ ( 3-13 )
42   -   10
AFC East
12/21/25
New England Patriots NE ( 13-3 )
Baltimore Ravens BAL ( 8-8 )
28   -   24
AFC East
12/21/25
Pittsburgh Steelers PIT ( 9-7 )
Detroit Lions DET ( 8-8 )
29   -   24
AFC North
12/15/25
Miami Dolphins MIA ( 7-9 )
Pittsburgh Steelers PIT ( 9-7 )
15   -   28
AFC East
12/14/25
Buffalo Bills BUF ( 11-5 )
New England Patriots NE ( 13-3 )
35   -   31
AFC East
12/07/25
Pittsburgh Steelers PIT ( 9-7 )
Baltimore Ravens BAL ( 8-8 )
27   -   22
AFC North
12/01/25
N.Y. Giants Giants NYG ( 3-13 )
New England Patriots NE ( 13-3 )
15   -   33
NFC East
11/30/25
Buffalo Bills BUF ( 11-5 )
Pittsburgh Steelers PIT ( 9-7 )
26   -   7
AFC East
11/23/25
Pittsburgh Steelers PIT ( 9-7 )
Chicago Bears CHI ( 11-5 )
28   -   31
AFC North
11/23/25
New England Patriots NE ( 13-3 )
Cincinnati Bengals CIN ( 6-10 )
26   -   20
AFC East
11/13/25
N.Y. Jets Jets NYJ ( 3-13 )
New England Patriots NE ( 13-3 )
14   -   27
AFC East

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Pittsburgh Steelers Pittsburgh Steelers
1 1 5-5 1L 0-2 0 0-0 0-0 2-0
New England Patriots New England Patriots
1 1 9-1 2W 1-1 0 0-0 0-0 1-1

Recent Meetings

date home-away ats o/u NE:Total Net Yards NE:Net Rushing Yards NE:Passing Yards PIT:Total Net Yards PIT:Net Rushing Yards PIT:Passing Yards
09/21/2025 NE 14 - PIT 21 PIT -1.5 Under 44.5 369 119 250 203 64 139
12/07/2023 PIT 18 - NE 21 NE +5.5 Over 30.5 303 81 222 264 82 182
09/18/2022 PIT 14 - NE 17 NE -3 Under 40 376 124 252 243 91 152
09/08/2019 NE 33 - PIT 3 NE -5.5 Under 51.5 308 32 276 465 99 366
12/16/2018 PIT 17 - NE 10 PIT +2.5 Under 52 368 96 272 376 158 218
12/17/2017 PIT 24 - NE 27 NE -2 Under 52.5 360 77 283 413 143 270
01/22/2017 NE 36 - PIT 17 NE -5.5 Over 50 368 54 314 431 57 374
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 CLE 13 - PIT 6 L -5.5 Under 34.5 291 131 160
12/21/2025 DET 24 - PIT 29 W +7 Over 51.5 496 230 266
12/15/2025 PIT 28 - MIA 15 W -3.5 Under 43 285 63 222
12/07/2025 BAL 22 - PIT 27 W +8.5 Over 43.5 318 34 284
11/30/2025 PIT 7 - BUF 26 L +3.5 Under 47.5 372 249 123
11/23/2025 CHI 31 - PIT 28 L +2.5 Over 46.5 345 186 159
11/16/2025 PIT 34 - CIN 12 W -5.5 Under 46.5 297 105 192
11/09/2025 LAC 25 - PIT 10 L +2.5 Under 45.5 221 73 148
11/02/2025 PIT 27 - IND 20 W +2.5 Under 51.5 368 55 313
10/26/2025 PIT 25 - GB 35 L +3 Over 46 454 94 360
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/28/2025 NYJ 10 - NE 42 W -12.5 Over 42.5 307 164 143
12/21/2025 BAL 24 - NE 28 W +2.5 Over 48.5 330 171 159
12/14/2025 NE 31 - BUF 35 L +4.5 Over 49.5 385 246 139
12/01/2025 NE 33 - NYG 15 W -7.5 Over 46.5 395 119 276
11/23/2025 CIN 20 - NE 26 L -6.5 Under 50 307 120 187
11/13/2025 NE 27 - NYJ 14 W -5.5 Under 42.5 336 65 271
11/09/2025 TB 23 - NE 28 W +2.5 Over 48 371 113 258
11/02/2025 NE 24 - ATL 23 L -4.5 Over 45.5 331 110 221
10/26/2025 NE 32 - CLE 13 W -7 Over 40.5 422 177 245
10/19/2025 TEN 13 - NE 31 W -6.5 Over 42.5 255 39 216

Matchup Edge - Scoring Stats

avg rank edge in rank avg
23.19 15 Points Per Game 5 28.25
22.69 15 Points Allowed Per Game 5 19.38
4.19 15 1st Quarter Scoring Per Game 2 6.75
3.81 6 1st Quarter Scoring Allowed Per Game 14 4.63
7.81 8 2nd Quarter Scoring Per Game 2 10.69
5.13 5 2nd Quarter Scoring Allowed Per Game 4 4.81
3.75 20 3rd Quarter Scording Per Game 10 5.63
3.75 8 3rd Quarter Scoring Allowed Per Game 6 3.56
7.44 6 4th Quarter Scoring Per Game 24 5.19
10 24 4th Quarter Scoring Allowed Per Game 12 6.38
59.6 12 Red Zone Efficiency 19 55.2
300.38 26 Total Yards Per Game 4 374.5
9.55 19 Total Yards Per Play 3 12.48
4.32 15 Rushing Yards Per Play 18 4.23
31.44 18 Passing Attempts Per Game 21 30
9.43 24 Passing Yards Per Completion 3 11.76
1.56 8 Passing Tds Per Game 5 1.88
20.88 13 Completions Per Game 10 21.5
66.4 9 Completion % 1 71.7
94.18 11 Qb Rating 1 112.54
1.81 19 Defense Sacks Per Game 7 3
0.56 10 Defense Interceptions Per Game 11 0.5
1.19 9 Opponent Fumbles Per Game 2 0.75
0.38 8 Opponent Fumbles Lost Per Game 6 0.5
6 8 Penalties Per Game 7 5.94
47.38 8 Penalty Yards Per Game 17 50.13
15 5 Takeaway / Giveaway Differential 6 16
4 18 Yards Per Punt Return 2 7.56
23.88 29 Yards Per Kickoff Return 18 25.45

Odds Analysis

Team Rankings

offence
Pittsburgh Steelers PIT
Season stats rank
Total Yards 300.4 26
Passing Yards 196.88 22
Rushing Yards 103.5 26
Points Scored 23.19 15
Field Goal % 0.83 22
New England Patriots NE
Season stats rank
Total Yards 374.5 4
Passing Yards 252.75 3
Rushing Yards 121.75 13
Points Scored 28.25 5
Field Goal % 0.87 15
defence
Pittsburgh Steelers PIT
Season stats rank
Total Yards 300.4 26
Passing Yards 196.88 22
Rushing Yards 103.5 26
Points Scored 23.19 15
Field Goal % 0.83 22
New England Patriots NE
Season stats rank
Total Yards 374.5 4
Passing Yards 252.75 3
Rushing Yards 121.75 13
Points Scored 28.25 5
Field Goal % 0.87 15

Injuries

Pittsburgh Steelers PIT
New England Patriots NE

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player