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Broncos vs. Chargers Prediction, Odds & Stats September 21, 2025

Final Score
AFC West
Sep 21st, 4:05 PM EDT
Denver
Broncos
L.A. Chargers
Chargers
20
23
Denver Broncos
Los Angeles Chargers
Scoreboard 1 2 3 4 Odds
Denver Broncos 14-3 0 7 10 3 +46
Los Angeles Chargers 11-6 3 7 3 10 -2.5

Latest Encounters

Date Result Competition Stats Recap
01/25/26
New England Patriots NE ( 14-3 )
Denver Broncos DEN ( 14-3 )
10   -   7
 AFC East
01/17/26
Buffalo Bills BUF ( 12-5 )
Denver Broncos DEN ( 14-3 )
30   -   33
 AFC East
01/11/26
L.A. Chargers Chargers LAC ( 11-6 )
New England Patriots NE ( 14-3 )
3   -   16
 AFC West
01/04/26
L.A. Chargers Chargers LAC ( 11-6 )
Denver Broncos DEN ( 14-3 )
3   -   19
 AFC West
12/27/25
Houston Texans HOU ( 12-5 )
L.A. Chargers Chargers LAC ( 11-6 )
20   -   16
 AFC South
12/25/25
Denver Broncos DEN ( 14-3 )
Kansas City Chiefs KC ( 6-11 )
20   -   13
 AFC West
12/21/25
Jacksonville Jaguars JAC ( 13-4 )
Denver Broncos DEN ( 14-3 )
34   -   20
 AFC South
12/21/25
L.A. Chargers Chargers LAC ( 11-6 )
Dallas Cowboys DAL ( 7-9 )
34   -   17
 AFC West
12/14/25
Green Bay Packers GB ( 9-6 )
Denver Broncos DEN ( 14-3 )
26   -   34
 NFC North
12/14/25
L.A. Chargers Chargers LAC ( 11-6 )
Kansas City Chiefs KC ( 6-11 )
16   -   13
 AFC West
12/08/25
Philadelphia Eagles PHI ( 11-6 )
L.A. Chargers Chargers LAC ( 11-6 )
19   -   22
 NFC East

Line History

Matchup Details

Denver Broncos DEN
L.A. Chargers Chargers LAC
Stat
1 Games Won 2
1 Games Lost 0
9-1 Last 10 7-3
0-0 W L Streak 0-0
1-1 Against The Spread 2-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
1-1 Total 1-1

Recent Meetings

date home-away ats o/u LAC:Total Net Yards LAC:Net Rushing Yards LAC:Passing Yards DEN:Total Net Yards DEN:Net Rushing Yards DEN:Passing Yards
01/04/2026 DEN 19 - LAC 3 DEN -7 Under 37.5 217 113 104 240 116 124
09/21/2025 LAC 23 - DEN 20 LAC -2.5 Under 45.5 376 106 270 265 118 147
12/19/2024 LAC 34 - DEN 27 LAC -2.5 Over 42 355 110 245 380 117 263
10/13/2024 DEN 16 - LAC 23 LAC -2.5 Over 37.5 350 128 222 316 110 206
12/31/2023 DEN 16 - LAC 9 DEN -5.5 Under 39.5 301 86 215 313 101 212
12/10/2023 LAC 7 - DEN 24 DEN +3 Under 44 322 106 216 283 76 207
01/08/2023 DEN 31 - LAC 28 LAC +6 Over 38.5 352 59 293 471 205 266
10/17/2022 LAC 19 - DEN 16 DEN +3.5 Under 45 258 98 160 297 73 224
01/02/2022 LAC 34 - DEN 13 LAC -8.5 Over 45.5 319 83 236 341 104 237
11/28/2021 DEN 28 - LAC 13 DEN +2.5 Under 47 357 72 285 302 147 155
12/27/2020 LAC 19 - DEN 16 LAC -3.5 Under 47.5 396 133 263 316 89 227
11/01/2020 DEN 31 - LAC 30 DEN +1.5 Over 44.5 485 210 275 351 108 243
12/01/2019 DEN 23 - LAC 20 DEN +4.5 Over 38.5 359 115 244 218 84 134
10/06/2019 LAC 13 - DEN 20 DEN +4 Under 44 350 191 159 246 35 211
12/30/2018 DEN 9 - LAC 23 LAC -7 Under 41.5 276 116 160 370 82 288
11/18/2018 LAC 22 - DEN 23 DEN +7.5 Under 46.5 325 108 217 479 95 384
10/22/2017 LAC 21 - DEN 0 LAC -1 Under 41 251 69 182 242 80 162
09/11/2017 DEN 24 - LAC 21 DEN -3 Over 44 249 64 185 321 140 181
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/25/2026 DEN 7 - NE 10 W +5.5 Under 40.5 206 141 65
01/17/2026 DEN 33 - BUF 30 W -1.5 Over 46.5 449 183 266
01/04/2026 DEN 19 - LAC 3 W -7 Under 37.5 217 113 104
12/25/2025 KC 13 - DEN 20 L +4.5 Under 38 303 128 175
12/21/2025 DEN 20 - JAC 34 L -3 Over 47 346 81 265
12/14/2025 DEN 34 - GB 26 W +2.5 Over 42.5 362 115 247
12/07/2025 LV 17 - DEN 24 L -7.5 Over 40.5 356 152 204
11/30/2025 WAS 26 - DEN 27 L -6.5 Over 43.5 402 87 315
11/16/2025 DEN 22 - KC 19 W +1.5 Under 45 311 62 249
11/06/2025 DEN 10 - LV 7 L -6.5 Under 42.5 188 74 114
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/11/2026 NE 16 - LAC 3 L +3.5 Under 45.5 381 146 235
01/04/2026 DEN 19 - LAC 3 L +7 Under 37.5 240 116 124
12/27/2025 LAC 16 - HOU 20 L -1.5 Under 41 275 74 201
12/21/2025 DAL 17 - LAC 34 W +1.5 Over 50.5 340 91 249
12/14/2025 KC 13 - LAC 16 W +5.5 Under 41.5 239 49 190
12/08/2025 LAC 22 - PHI 19 W +2.5 Over 40.5 275 169 106
11/30/2025 LAC 31 - LV 14 W -10 Over 41.5 341 192 149
11/16/2025 JAC 35 - LAC 6 L -3 Under 43.5 345 192 153
11/09/2025 LAC 25 - PIT 10 W -2.5 Under 45.5 314 115 199
11/02/2025 TEN 20 - LAC 27 L -10.5 Over 44 206 88 118

Matchup Edge - Scoring Stats

Denver Broncos DEN
L.A. Chargers Chargers LAC
avg rank edge in rank avg
2.1 1 Qb Rating 1 2.1

Odds Analysis

Team Rankings

Denver Broncos DEN
Season stats rank
Total Yards 278.2 2
Passing Yards 187.18 8
Rushing Yards 91.06 2
Points Scored 18.29 3
Field Goal % 0.95 31
L.A. Chargers Chargers LAC
Season stats rank
Total Yards 285.2 5
Passing Yards 179.88 5
Rushing Yards 105.35 8
Points Scored 20 9
Field Goal % 0.89 23
Denver Broncos DEN
Season stats rank
Total Yards 342.6 10
Passing Yards 223.94 11
Rushing Yards 118.71 16
Points Scored 23.59 14
Field Goal % 0.88 13
L.A. Chargers Chargers LAC
Season stats rank
Total Yards 333.8 12
Passing Yards 212.24 18
Rushing Yards 121.59 12
Points Scored 21.65 20
Field Goal % 0.93 4

Injuries

Denver Broncos DEN
L.A. Chargers Chargers LAC

Denver vs. L.A. Chargers Betting News

Denver Broncos DEN

No posts found.
L.A. Chargers Chargers LAC

No posts found.

Denver Vs L.A. Chargers Betting Trends

Denver Broncos DEN

Broncos are 5-1 ATS in their last 6 games following a straight up loss.

Broncos are 5-0 ATS in their last 5 games as a favorite of 3.5-10.0.

Broncos are 5-1 ATS in their last 6 games following a ATS loss.

Over is 11-4-1 in Broncos last 16 games overall.

Broncos are 6-2 ATS in their last 8 games as a road favorite of 3.5-10.0.

L.A. Chargers Chargers LAC

Chargers are 16-5-1 ATS in their last 22 games as a favorite of 3.5-10.0.

Over is 6-1 in Chargers last 7 games overall.

Chargers are 8-2 ATS in their last 10 games as a favorite.

Under is 6-2 in Chargers last 8 games after allowing less than 15 points in their previous game.

Chargers are 5-2 ATS in their last 7 home games.

AFC West Standings

Line Up - Last Game

Denver Broncos
Pitchers
POS Player
Hitters
POS Player
Los Angeles Chargers
Pitchers
POS Player
Hitters
POS Player
  • DEN
  • +2.5 -2.5
  • LAC
NFL Odds