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49ers vs. Rams Prediction, Odds & Stats September 10, 2026

Final Score
NFC West
Sep 10th, 8:35 PM EDT
San Francisco
49ers
L.A. Rams
Rams
27
7
San Francisco 49ers
Los Angeles Rams
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 3-0 3 7 7 10 +48.5
Los Angeles Rams 1-2 0 7 0 0 -3.5
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Latest Encounters

Date Result Competition Stats Recap
09/27/26
L.A. Rams Rams LAR ( 1-2 )
Denver Broncos DEN ( 2-1 )
26   -   30
 NFC West
09/27/26
Arizona Cardinals ARI ( 1-2 )
San Francisco 49ers SF ( 3-0 )
30   -   36
 NFC West
09/21/26
N.Y. Giants Giants NYG ( 2-1 )
L.A. Rams Rams LAR ( 1-2 )
6   -   28
 NFC East

Line History

Matchup Details

San Francisco 49ers SF
L.A. Rams Rams LAR
Stat
0 Games Won 0
0 Games Lost 0
3-0 Last 10 1-2
0-0 W L Streak 0-0
0-0 Against The Spread 0-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
0-0 Total 0-0

Recent Meetings

date home-away ats o/u LAR:Total Net Yards LAR:Net Rushing Yards LAR:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
09/10/2026 LAR 7 - SF 27 SF +2.5 Under 48.5 290 122 168 379 174 205
11/09/2025 SF 26 - LAR 42 LAR -6 Over 46.5 401 126 275 393 74 319
10/02/2025 LAR 23 - SF 26 SF +8.5 Over 47.5 407 74 333 456 78 378
12/12/2024 SF 6 - LAR 12 LAR +1.5 Under 48.5 302 142 160 191 63 128
09/22/2024 LAR 27 - SF 24 LAR +6.5 Over 45 425 137 288 296 98 198
01/07/2024 SF 20 - LAR 21 LAR +3 Under 43 258 109 149 300 125 175
09/17/2023 LAR 23 - SF 30 SF -7 Over 45 365 159 206 386 89 297
10/30/2022 LAR 14 - SF 31 SF -1 Over 42.5 368 111 257 223 56 167
10/03/2022 SF 24 - LAR 9 SF -1 Under 42 257 57 200 327 88 239
01/30/2022 LAR 20 - SF 17 LAR -3.5 Under 46 282 50 232 396 70 326
01/09/2022 LAR 24 - SF 27 SF +3.5 Over 44.5 449 135 314 265 64 201
11/15/2021 SF 31 - LAR 10 SF +3.5 Under 50 278 52 226 335 156 179
11/29/2020 LAR 20 - SF 23 SF +5 Under 45 345 112 233 308 126 182
10/18/2020 SF 24 - LAR 16 SF +3 Under 49.5 311 113 198 390 122 268
12/21/2019 SF 34 - LAR 31 LAR +6 Over 45.5 395 72 323 334 119 215
10/13/2019 LAR 7 - SF 20 SF +3 Under 49.5 331 99 232 157 109 48
12/30/2018 LAR 48 - SF 32 LAR -10.5 Over 49.5 391 127 264 377 155 222
10/21/2018 SF 10 - LAR 39 LAR -11 Under 52 339 146 193 228 107 121
12/31/2017 LAR 13 - SF 34 SF +6.5 Over 44 461 169 292 251 102 149
09/21/2017 SF 39 - LAR 41 SF +2.5 Over 40.5 418 126 292 421 113 308
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
09/27/2026 SF 36 - ARI 30 L -8.5 Over 48 365 93 272
09/20/2026 SF 35 - MIA 13 W -10.5 Over 46 284 102 182
09/10/2026 LAR 7 - SF 27 W +2.5 Under 48.5 379 174 205
08/27/2026 LV 12 - SF 18 W +1 Under 38.5 281 146 135
08/20/2026 LAC 17 - SF 41 W +1 Over 39.5 321 146 175
08/13/2026 SF 13 - TEN 19 L +2 Under 38.5 279 167 112
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
09/27/2026 DEN 30 - LAR 26 L -2.5 Over 45.5 257 78 179
09/21/2026 LAR 28 - NYG 6 W -7 Under 47.5 481 163 318
09/10/2026 LAR 7 - SF 27 L -2.5 Under 48.5 290 122 168
08/27/2026 LAC 18 - LAR 20 W +2.5 Under 39.5 394 204 190
08/22/2026 LAR 34 - NO 0 W +1 Under 38.5 405 151 254
08/15/2026 KC 12 - LAR 20 W +1.5 Under 36.5 314 125 189

Odds Analysis

Team Rankings

San Francisco 49ers SF
Season stats rank
Total Yards 313 9
Passing Yards 207.33 15
Rushing Yards 105.67 15
Points Scored 16.67 3
Field Goal % 0.83 14
L.A. Rams Rams LAR
Season stats rank
Total Yards 272.7 3
Passing Yards 171.33 4
Rushing Yards 101.33 11
Points Scored 21 13
Field Goal % 0.67 6
San Francisco 49ers SF
Season stats rank
Total Yards 399.3 5
Passing Yards 263 7
Rushing Yards 136.33 6
Points Scored 32.67 2
Field Goal % 0.75 22
L.A. Rams Rams LAR
Season stats rank
Total Yards 417.7 1
Passing Yards 284 2
Rushing Yards 133.67 7
Points Scored 20.33 20
Field Goal % 0.8 20

Injuries

San Francisco 49ers SF
L.A. Rams Rams LAR

San Francisco vs. L.A. Rams Betting News

San Francisco 49ers SF

No posts found.
L.A. Rams Rams LAR

No posts found.

San Francisco Vs L.A. Rams Betting Trends

San Francisco 49ers SF

Over is 6-2 in 49ers last 8 games as a favorite.

Under is 10-2 in 49ers last 12 games in Week 1.

49ers are 2-5 ATS in their last 7 games as an underdog of 0.5-3.0.

Over is 6-1 in 49ers last 7 games as an underdog of 3.5-10.0.

49ers are 2-7 ATS in their last 9 games as an underdog of 3.5-10.0.

L.A. Rams Rams LAR

Over is 4-1 in Rams last 5 Thursday games.

Over is 6-1 in Rams last 7 games as a favorite.

Over is 5-1 in Rams last 6 games on grass.

Under is 4-0 in Rams last 4 games in Week 1.

Over is 8-1 in Rams last 9 vs. NFC.

NFC West Standings

Line Up - Last Game

San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player
Los Angeles Rams
Pitchers
POS Player
Hitters
POS Player
  • SF
  • +3.5 -3.5
  • LAR
NFL Odds