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49ers vs. Rams Prediction, Odds & Stats September 10, 2026

Final Score
NFC West
Sep 10th, 8:35 PM EDT
San Francisco
49ers
L.A. Rams
Rams
27
7
San Francisco 49ers
Los Angeles Rams
Scoreboard 1 2 3 4 Odds
San Francisco 49ers 7-1 3 7 7 10 +48.5
Los Angeles Rams 5-4 0 7 0 0 -3.5
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Latest Encounters

Date Result Competition Stats Recap
11/08/26
Las Vegas Raiders LV ( 4-5 )
San Francisco 49ers SF ( 7-1 )
17   -   38
 AFC West
11/08/26
L.A. Rams Rams LAR ( 5-4 )
Washington Commanders WAS ( 3-5 )
20   -   13
 NFC West
11/01/26
L.A. Chargers Chargers LAC ( 0-8 )
L.A. Rams Rams LAR ( 5-4 )
9   -   24
 AFC West

Line History

Matchup Details

San Francisco 49ers SF
L.A. Rams Rams LAR
Stat
0 Games Won 0
0 Games Lost 0
7-1 Last 10 5-4
0-0 W L Streak 0-0
0-0 Against The Spread 0-0
0 Money 0
0-0 Home 0-0
0-0 Away 0-0
0-0 Total 0-0

Recent Meetings

date home-away ats o/u LAR:Total Net Yards LAR:Net Rushing Yards LAR:Passing Yards SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards
09/10/2026 LAR 7 - SF 27 SF +2.5 Under 48.5 290 122 168 379 174 205
11/09/2025 SF 26 - LAR 42 LAR -6 Over 46.5 401 126 275 393 74 319
10/02/2025 LAR 23 - SF 26 SF +8.5 Over 47.5 407 74 333 456 78 378
12/12/2024 SF 6 - LAR 12 LAR +1.5 Under 48.5 302 142 160 191 63 128
09/22/2024 LAR 27 - SF 24 LAR +6.5 Over 45 425 137 288 296 98 198
01/07/2024 SF 20 - LAR 21 LAR +3 Under 43 258 109 149 300 125 175
09/17/2023 LAR 23 - SF 30 SF -7 Over 45 365 159 206 386 89 297
10/30/2022 LAR 14 - SF 31 SF -1 Over 42.5 368 111 257 223 56 167
10/03/2022 SF 24 - LAR 9 SF -1 Under 42 257 57 200 327 88 239
01/30/2022 LAR 20 - SF 17 LAR -3.5 Under 46 282 50 232 396 70 326
01/09/2022 LAR 24 - SF 27 SF +3.5 Over 44.5 449 135 314 265 64 201
11/15/2021 SF 31 - LAR 10 SF +3.5 Under 50 278 52 226 335 156 179
11/29/2020 LAR 20 - SF 23 SF +5 Under 45 345 112 233 308 126 182
10/18/2020 SF 24 - LAR 16 SF +3 Under 49.5 311 113 198 390 122 268
12/21/2019 SF 34 - LAR 31 LAR +6 Over 45.5 395 72 323 334 119 215
10/13/2019 LAR 7 - SF 20 SF +3 Under 49.5 331 99 232 157 109 48
12/30/2018 LAR 48 - SF 32 LAR -10.5 Over 49.5 391 127 264 377 155 222
10/21/2018 SF 10 - LAR 39 LAR -11 Under 52 339 146 193 228 107 121
12/31/2017 LAR 13 - SF 34 SF +6.5 Over 44 461 169 292 251 102 149
09/21/2017 SF 39 - LAR 41 SF +2.5 Over 40.5 418 126 292 421 113 308
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/08/2026 SF 38 - LV 17 W -8.5 Over 52 240 24 216
10/25/2026 ATL 29 - SF 20 L -4.5 Under 49.5 411 123 288
10/19/2026 SF 23 - WAS 17 L -7.5 Under 52 314 53 261
10/11/2026 SEA 29 - SF 32 W +3 Over 47 269 94 175
10/04/2026 SF 24 - DEN 14 W -2.5 Under 46 296 82 214
09/27/2026 SF 36 - ARI 30 L -8.5 Over 48 365 93 272
09/20/2026 SF 35 - MIA 13 W -10.5 Over 46 284 102 182
09/10/2026 LAR 7 - SF 27 W +2.5 Under 48.5 379 174 205
08/27/2026 LV 12 - SF 18 W +1 Under 38.5 281 146 135
08/20/2026 LAC 17 - SF 41 W +1 Over 39.5 321 146 175
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
11/08/2026 WAS 13 - LAR 20 W -6 Under 48 334 60 274
11/01/2026 LAR 24 - LAC 9 W -6.5 Under 45.5 281 129 152
10/25/2026 LV 21 - LAR 35 W -6 Over 50 350 48 302
10/18/2026 LAR 16 - ARI 18 L -12.5 Under 51.5 286 92 194
10/12/2026 LAR 34 - BUF 37 L -2.5 Over 54.5 454 77 377
10/04/2026 PHI 20 - LAR 24 W -2.5 Under 47 172 104 68
09/27/2026 DEN 30 - LAR 26 L -2.5 Over 45.5 257 78 179
09/21/2026 LAR 28 - NYG 6 W -7 Under 47.5 481 163 318
09/10/2026 LAR 7 - SF 27 L -2.5 Under 48.5 290 122 168
08/27/2026 LAC 18 - LAR 20 W +2.5 Under 39.5 394 204 190

Odds Analysis

Team Rankings

San Francisco 49ers SF
Season stats rank
Total Yards 291.9 3
Passing Yards 211 8
Rushing Yards 80.88 2
Points Scored 19.5 6
Field Goal % 0.89 23
L.A. Rams Rams LAR
Season stats rank
Total Yards 302.4 5
Passing Yards 198.67 5
Rushing Yards 103.78 14
Points Scored 20.11 8
Field Goal % 0.88 20
San Francisco 49ers SF
Season stats rank
Total Yards 376.8 6
Passing Yards 241.5 11
Rushing Yards 135.25 7
Points Scored 29.38 3
Field Goal % 0.7 29
L.A. Rams Rams LAR
Season stats rank
Total Yards 379.8 4
Passing Yards 254.44 7
Rushing Yards 125.33 9
Points Scored 23.78 13
Field Goal % 0.69 30

Injuries

San Francisco 49ers SF
L.A. Rams Rams LAR

San Francisco vs. L.A. Rams Betting News

San Francisco Vs L.A. Rams Betting Trends

San Francisco 49ers SF

Over is 6-2 in 49ers last 8 games as a favorite.

Under is 10-2 in 49ers last 12 games in Week 1.

49ers are 2-5 ATS in their last 7 games as an underdog of 0.5-3.0.

Over is 6-1 in 49ers last 7 games as an underdog of 3.5-10.0.

49ers are 2-7 ATS in their last 9 games as an underdog of 3.5-10.0.

L.A. Rams Rams LAR

Over is 4-1 in Rams last 5 Thursday games.

Over is 6-1 in Rams last 7 games as a favorite.

Over is 5-1 in Rams last 6 games on grass.

Under is 4-0 in Rams last 4 games in Week 1.

Over is 8-1 in Rams last 9 vs. NFC.

NFC West Standings

Line Up - Last Game

San Francisco 49ers
Pitchers
POS Player
Hitters
POS Player
Los Angeles Rams
Pitchers
POS Player
Hitters
POS Player
  • SF
  • +3.5 -3.5
  • LAR
NFL Odds