Toronto Blue Jays vs. St. Louis Cardinals: Odds, Prediction

Payton Matthews | Updated May 23, 2022

Toronto starts a six-game road trip Monday with its first visit of the season to a National League team as the Jays take on the Cardinals in St. Louis, arguably the best baseball town in the USA.

May 23, 2022, 7:45 PM ET
Busch Stadium
St. Louis
Runline +1.5 -206
Moneyline -115
Over / Under o +7.5


Betting Action


Runline -1.5 +171
Moneyline -105
Over / Under u +7.5


Betting Action


The Cards are slight favourites Monday on the MLB odds with a total of 8.0 runs.

Jays vs. Cardinals Betting Analysis

Just a reminder (and our last one in this regard) that in past seasons, the Blue Jays would lose the designated hitter visiting a National League park, but the universal DH is here to stay.

This is the final season in MLB (so they say) for two future Hall of Famers on the Cardinals in designated hitter/first baseman Albert Pujols and catcher Yadier Molina. They will both be first-ballot Hall of Famers, and Pujols should be a unanimous pick. He had two homers in Sunday’s win in Pittsburgh and is fifth on the all-time homer list, 13 behind Alex Rodriguez. Sunday’s game was such a rout that Molina pitched for the first time in his career.

These teams haven’t met since 2017 when the Jays lost two of three in St. Louis. The Cards come to Toronto on July 26-27.

Toronto Blue Jays

The Jays weren’t able to finish a home sweep of Cincinnati on Sunday, losing 3-2 on an eighth-inning homer from Toronto native Joey Votto. The offence continues to underachieve: Toronto’s has scored 147 runs, ahead of only last-place Baltimore in the AL East. The Jays also have a negative overall differential of minus-10. Vladimir Guerrero Jr. didn’t have a hit in the series. Santiago Espinal did extend his career-best hitting streak to 15 games Sunday. That’s the longest active streak in the majors. It’s right-hander Jose Berrios (3-2, 4.83 ERA) on the bump here. He comes off his best start of the season, seven shutout innings last Tuesday vs. Seattle. Berrios has struggled on the road, though, at 1-2 with a 6.43 ERA in four starts. He faced the Cardinals twice in his career while with the Twins, allowing four earned over 12.1 innings. Albert Pujols is 3-for-6 career off him. Toronto is 2-5 in its past seven series openers.

St. Louis Cardinals

Over the weekend, the Cardinals called up highly touted prospect Nolan Gorman, and the infielder went 5-for-10 with two doubles in his first series in the majors. However, the Cards lost starting pitcher and former Blue Jay Steven Matz after just four pitches Sunday with a shoulder injury. Outfielder Dylan Carlson was out of the lineup Sunday with left hamstring tightness and probably will miss this series. He’s batting .247 with two homers and 11 RBIs. Despite being on a 14-game hitting streak, Paul Goldschmidt got Sunday off. Eleven of his last 16 hits have gone for extra bases. It’s veteran right-hander Miles Mikolas (3-2, 1.68 ERA) on the mound. He has allowed two earned or fewer in all eight starts. This will be his first career start against Toronto. He’s 4-2 with a 3.43 ERA (42.0 IP) and 36 strikeouts in nine career interleague games. St. Louis has won 14 of its past 20 series openers.

MLB Prediction: Who Will Win Blue Jays vs. Cardinals?