Inter Miami vs. Charlotte FC MLS Betting Odds, Picks: Herons heavy favourites in regular season finale

MLS continues to creep towards the looming playoffs as teams rally for game 34 out of 35 this season.

Inter Miami are a top-three favourite to win the MLS Cup, but they’ll have to overcome Dean Smith’s Charlotte FC with haste.

Do not miss out on one of this MLS season’s most exhilarating matchups with Inter Miami taking on Charlotte FC on Saturday.

Inter Miami vs. Charlotte FC MLS Odds and Betting Trends

Since their first confrontation in this fixture in 2023, Inter Miami hold four total wins out of 10 total meetings, while Charlotte FC have won three.

Miami has not beaten or scored against Charlotte since March 9, 2025, with the last result between the two sides on matchday four of this season ending scoreless.

The Herons have also never lost a home game to their Charlotte opponents.

For this weekend’s skirmish, Inter Miami host their opponents as -250 favourites on the MLS odds.

Charlotte are nothing less than challenging opponents, but they will head to Nu Stadium as considerable +500 underdogs, with a draw priced at +450.

Despite some of the low-scoring history, this match has over 3.5 goals favoured at -170, versus the under 3.5 at +132.

Inter Miami

Javier Mascherano’s men have won some silverware this season (Campeones Cup), but the Herons hit a tough road in their last five matches to achieve a 3-1-1 record while still holding second place with 59 points. At this rate, Miami is likely to secure the second seed in the East, especially if they overcome Charlotte here.

After a last-minute 2-2 draw secured by Riquelme Fillipi against FC Cincinnati with some late goal-scoring action to see out October, the side pulled off a notable 2-1 comeback win against the third-place New England Revolution. Of course, it all came down to none other than Lionel Messi to score a left-footed game-winner in the 83rd minute before an 87th-minute Revs strike was ruled out by VAR, giving Miami the win.

Messi added to his now 26-goal tally after 30 games this season, and is unquestionably this matchup’s most likely goalscorer at -300 odds.

Charlotte FC

Charlotte FC are looking mighty dangerous, and have already broken their goal count from last season by eight goals, as they are on 63 with two games left to play in the regular season. A win for Smith’s squad here could allow them to overtake Chicago in fourth place depending on how the Fire fare against Columbus in their matchup.

With playoff seeds on the line, Charlotte FC (+500) will have nothing else on their minds but a win, something they may find very challenging to do given that they have not won an away game since September 19. However, their two most recent matchups at the end of October and beginning of November both resulted in 4-0 wins over Montreal and Orlando City.

Idan Toklomati has been in hot form with eight goals in his last 10 matches, and four in his last five, as he comes in as his team’s highest probable goalscorer at +175 odds. Pep Biel follows his fellow Israeli forward at +220 to knock one in, with 13 to his name heading into the final stages of the regular season.

MLS Prediction: Who Will Win Inter Miami vs. Charlotte FC?

While Charlotte looks a formidable opponent for the 2025 Cup winners, there are two major factors to consider here, Leo Messi aside.

In this fixture, out of five away matches, Charlotte have never beaten Inter Miami on their turf. Combine that with the fact that Charlotte has gone 1-2-2 in their last five away games, and they now face a very dominant home side that has suffered only two home losses this season.

Mascherano’s side runs away with the highest goal count in the MLS (77), as the Herons inch ever closer to beating their regular-season goal count from last season.

Messi will inevitably do something impactful in these types of matches, and with the support of talent like Rodrigo De Paul, Casemiro, Suárez, Segovia, and Berterame, Miami are fancied to outscore Charlotte here, potentially in a 3-1 result.