Chicago Fire vs. Inter Miami: MLS Betting Odds, Picks, Predictions

Matchday 24 of the MLS concludes with a highly anticipated Eastern Conference matchup when third-placed Chicago Fire host second-placed Inter Miami.

Robert Lewandowski’s Fire side enters this one with a game in hand, and a victory would move them to within two points of Lionel Messi’s Herons.

Prepare for some epic midweek MLS action, with kickoff between the two sides Wednesday at 8.30 p.m. ET.

Chicago Fire vs. Inter Miami MLS Odds and Betting Trends

This will be the 12th time the two Eastern sides have met, with the Fire leading the head-to-head with five wins to Miami’s four, and only two draws.

Miami won their last meeting in July, their third victory in five clashes, while Chicago has not won at home against these opponents since October 2023. The last two matches ended with five or more goals.

With the Fire’s impressive season, they stand at +115 on the MLS odds to beat these tough opponents, while Miami’s chances of snatching a road win land at +175. Draws have occurred only twice in this fixture, with Wednesday’s odds at +320; over 3.5 goals is highly expected at -148, while the under 3.5 sits at +116.

Inter Miami

While last year’s MLS Cup winners sit second in the Eastern Conference, they have dropped a significant number of points over the last six MLS matchups.

The side also struggled with two losses in three Leagues Cup group-stage matches, partly due to Messi’s absence. The team still showcases exceptional attacking options, though, defeating Montreal 7-1 on August 29, before drawing Atlanta United 2-2.

Javier Mascherano’s side have scored in their last 23 games in all competitions and boast the most goals in MLS (58), which will likely be their strength against another potent attacking side.

MLS top scorer Messi enters the matchup with 18 goals in 20 games and is priced at -135 as an anytime goalscorer. The Argentine’s strike partner, Luis Suarez, who has scored 12 times this season, trails not far behind at +135 to find the net.

Chicago Fire

The Chicago Fire finished August brilliantly and kicked off September undefeated, with no losses in their last six MLS games. With 11 wins this season, they sit in third place behind Miami on 38 points with a game in hand, which means a victory here could be crucial for achieving a top-two finish.

While the Fire failed to win their last three MLS games, they’ve scored seven goals, with their most recent outing against Toronto last Saturday ending in a 4-4 draw, as Maren Haile-Selassie scored a brace, while Lewandowski netted for the fifth time in the MLS.

Lewandowski is no stranger to putting the ball in the back of the net, and he enters the night at -130 odds to score anytime.

Teammate Philip Zinckernagel (five goals) finds himself set up as the team’s next highest probable scorer at +140.

MLS Prediction: Who Will Win Chicago Fire vs. Inter Miami?

If one team were dominant in their current form, this one would be a different story. However, both sides have dropped points since the MLS’ restart following the World Cup, and two main things stand out.

Firstly, Chicago is at home and have not lost there since May, while Miami have won only one of their last three away games, despite racking up 12 total wins this season.

The second is that there will most certainly be goals, with over 3.5 more than likely, seeing as the pitch contains the likes of Messi (18 goals), Lewandowski (five goals), Suarez (12 goals) and Haile-Selassie (seven goals), as both sides enter with seven or more goals scored in their last three MLS matchups.

With both teams securing draws in recent matchups, this one may end in a tie as well. Chicago tends to defend well enough to secure at least a point (only 32 goals allowed), while Miami have unprecedented goal-scoring power (58 goals scored).