Rams vs. Seahawks Point Spread: NFL Week 5 Odds, Prediction

Payton Matthews | Updated Oct 05, 2021

The NFC West will kick-off Week 5 of the 2021 NFL season, with the Seattle Seahawks hosting the Los Angeles Rams for Thursday Night Football.

L.A. Rams
October 07, 2021, 8:20 PM ET
CenturyLink Field
Pointspread -3 -113
Moneyline -153
Over / Under o +54


Betting Action


Pointspread +3 -107
Moneyline +127
Over / Under u +54


Betting Action


The Seattle Seahawks are on a crazy-good winning streak when it comes to Thursday games, but they are 2-point home underdogs on the NFL odds to kick off Week 5 against the Los Angeles Rams. The total is set at 54.5 points.

NFL Point Spread and Betting Analysis

These rivals probably will be sick of seeing each other as it will be their fourth meeting in less than 12 months – they split last regular season with each winning a low-scoring game at home. Seattle hosted Los Angeles in an NFC wild-card game and the Rams pulled off a 30-20 upset.

Cam Akers (out injured this season) rushed for 131 yards and a touchdown, while Darious Williams returned Russell Wilson‘s interception 42 yards for a score. That top-rated Rams defence allowed just 278 yards. Wilson was an ugly 11-for-27 passing and he was so unhappy about his pass protection (sacked five times, hit many more) that for a while this off-season he was pushing to be traded from Seattle.

With Arizona at 4-0 in the NFC West, neither team can afford a loss here even as early as it is – especially Seattle. Rather amazingly, the Seahawks have won nine straight games on Thursdays. The NFL record for consecutive wins on that day/night is 11 by the Indianapolis Colts from 2004-2015. Under Coach Sean McVay, the Rams have won three of four games played on Thursday.

Los Angeles Rams

Los Angeles had a case as the NFL’s best team through three weeks but was dominated for the most part Sunday in a 37-20 loss to those first-place Arizona Cardinals. It was L.A.’s largest NFC West loss under Coach Sean McVay since a 21-point defeat to the San Francisco 49ers in Week 17 of 2017 when McVay rested starters. The Rams’ defence was gashed for 465 yards by Arizona.

Matthew Stafford completed 26-of-41 passes for 280 yards, two touchdowns and an interception and a lot of his good numbers came in garbage time. Stafford still ranks second in the NFL with 11 touchdown passes and fourth in passing yards (1,222) and passer rating (117.6). Running back Darrell Henderson returned after missing one game injured and had 89 yards on 14 carries. The Rams are 5-1 ATS in their past six after a loss.

Seattle Seahawks

Seattle snapped a two-game skid – Russell Wilson still has yet to lose three in a row in his career – with a 28-21 upset in San Francisco on Sunday. Wilson threw for two scores and rushed for another. It was Wilson’s 100th career regular-season win to join Peyton Manning as the only quarterbacks with 100 regular-season wins in their first 10 seasons. Wilson also has had a passer rating of at least 110.0 every game this year with no picks. He’s just the third QB to do that in his team’s first four games and leads the NFL with a 129.9 rating.

Tight end Gerald Everett missed the game on the COVID list and it’s too early to tell if he will play here. Everett has eight catches for 77 yards and a touchdown. Top defensive end Carlos Dunlap also is in question. Seattle is 2-9 ATS in its past 11 after a win.

NFL Prediction: Who Will Win Rams vs. Seahawks?