NFL Week 6 Odds and Predictions: Best Picks Against the Spread for Every Game

As we enter Week 6, there are only three teams still unbeaten in the NFL: Kansas City, Minnesota and San Francisco. This week features yet another London game, with Cincinnati, Detroit, Miami and Minnesota on byes. Here’s a look at all Week 6 matchups with ATS picks on the NFL odds. Games Sunday unless noted.

Seattle Seahawks at Denver Broncos, Thursday

We nearly saw these teams play in Super Bowl 60 and certainly could in SB 61. Denver played without both starting cornerbacks Sunday, including former Defensive Player of the Year Patrick Surtain II, but escaped at the winless Chargers thanks to yet another fourth-quarter comeback from Bo Nix. Seattle was upset at home by the unbeaten 49ers due largely to four turnovers. Sam Darnold has looked shaky at times in the early going.

Point spread: Seahawks -2

Pick ATS: Denver alt +3.5

Houston Texans “at” Jacksonville Jaguars

Second game in a row in London for the Jaguars, but this time at Wembley Stadium. This past Sunday at Tottenham Hotspur Stadium, Jacksonville got essentially a miracle 19-17 win over Philadelphia thanks to an incredibly bad last-second decision by the Eagles’ head coach. Houston got its first win of the year easily at winless Tennessee on Sunday and also completed a trade for wideout Marvin Harrison Jr., a one-touted former No. 4 overall pick by Arizona.

Point spread: Jaguars -2.5

Pick ATS: Jacksonville

Chicago Bears at Atlanta Falcons

There’s a chance the Bears get starting QB Caleb Williams back this week from injury but most likely it will be backup Tyson Bagent or third-stringer Case Keenum again. Both were pretty bad in Sunday’s blowout loss in Green Bay. Atlanta caught a massive Sunday night break in hosting a Ravens team without superstar QB Lamar Jackson, but the Falcons couldn’t hold a late 8-point lead and lost in OT. Starting QB Michael Penix Jr. got banged up and is in some question this week.

Point spread: Bears -3.5

Pick ATS: Atlanta

Baltimore Ravens at Cleveland Browns

Baltimore has won the past three in this AFC North matchup. There is “some hope” that Ravens QB and former two-time league MVP Lamar Jackson can play after missing Week 5 with an ankle injury. Backup Tyler Huntley led a rally from down eight late in the fourth quarter with an upset victory in Atlanta on Sunday. That snapped a leaguewide 581-game losing streak by teams down at least eight in the final minute of regulation. Cleveland had a three-game winning streak snapped in a 17-12 loss at the Jets. Deshaun Watson had a rough game but will remain the starting QB.

Point spread: Ravens -4.5

Pick ATS: Baltimore

Tennessee Titans at Indianapolis Colts

The Colts have won six straight over their AFC South rivals. Both teams are pretty bad this year, especially the winless Titans. They were clobbered at home Sunday by Houston and are the third club in the past 15 seasons with under 21 points and 300 total yards in each of the first five games. QB Cam Ward perhaps isn’t the answer. Indy had a two-game winning streak snapped in a 34-22 loss in Pittsburgh. The team is now 3-11 in its past 14 games.

Point spread: Colts -6.5

Pick ATS: Indianapolis

New York Jets at New England Patriots

New England has won the past three in the AFC East series. The Jets snapped a three-game skid with a 17-12 home win over Cleveland thanks to eight sacks. The team had nine in the first four games combined. Rookie pass-rusher David Bailey has been stellar, now at five sacks. The Patriots looked off early in the season but everything was clicking in a second straight win Sunday, 45-17 over Las Vegas. Drake Maye threw for four scores and rushed for one. The Pats are hoping top WR AJ Brown can come off injured reserve this week.

Point spread: Patriots -7.5

Pick ATS: New England alt -7

New Orleans Saints at New York Giants

New Orleans lost a third straight game Sunday, 23-13 at home vs. unbeaten Minnesota. It was the Saints’ first loss since 2024 when forcing at least two turnovers as the offence did nothing. The Giants rallied from down 14 in the fourth quarter Sunday at Washington and tied 27-all. Both teams should have won it in OT but made terrible mistakes. New York’s 3-1-1 start is the best in NFL history through five games following consecutive 13-loss seasons all-time.

Point spread: Saints -1.5

Pick ATS: New York

Carolina Panthers at Philadelphia Eagles

Carolina comes out of its bye week having alternated losses and wins over its first four and with QB Bryce Young off to the best start of his career. Canadian running back Chuba Hubbard (from Edmonton) also is having a good season with 61 carries for 306 yards and three scores while adding two receiving TDs. It’s half-surprising that Eagles head coach Nick Sirianni has a job still after his disastrous decision Sunday to kick off in full against Jacksonville in London let to a crushing walk-off 19-17 loss. Offensive stars in tailback Saquon Barkley and wideout DeVonta Smith missed it injured.

Point spread: Eagles -1.5

Pick ATS: Philadelphia

Pittsburgh Steelers at Tampa Bay Buccaneers

Pittsburgh has alternated wins and losses all season and is off a 34-22 home win over Indianapolis. Aaron Rodgers passed Steelers legend Ben Roethlisberger for the fifth-most wins by a QB all-time (166) and tied a team record with at least three passing TDs in three straight games. The Bucs were winless and nearly double-digit dogs on Thursday night in Week 5 in Dallas but stunned the Cowboys, 24-16. Tampa Bay outscored Dallas 17-0 in the third and outgained it 197-59 behind an undrafted rookie QB.

Point spread: Steelers -2.5

Pick ATS: Tampa Bay alt +3

Arizona Cardinals at Los Angeles Rams

The Rams easily swept the Cardinals last season and have taken the past three. Short week for Los Angeles after losing 37-34 in OT to visiting Buffalo on Monday night in a possible Super Bowl preview. Special teams were a disaster, and Coach Sean McVay said after that he would “evaluate everything” with his loaded team at 2-3. Arizona lost its fourth game in a row Sunday, 45-21 at home vs. Detroit. The Cards have surrendered at least 31 points in each of those defeats. Just a barren roster for the most part on defence.

Point spread: Rams -12.5

Pick ATS: Arizona alt +13

Los Angeles Chargers at Kansas City Chiefs

These teams are polar opposites of what they were last season. The Chargers are shockingly 0-5 following Sunday’s 23-17 home loss to Denver, blowing a 17-10 fourth-quarter lead. They might start selling pieces ahead of the trade deadline. The Chiefs regressed massively last year but are out of their bye at 4-0. Patrick Mahomes looks healthy and the addition of tailback Kenneth Walker III has been a revelation as the reigning Super Bowl MVP is a top early Offensive Player of the Year candidate. The Chargers had a rare sweep of the Chiefs last season.

Point spread: Chiefs -8.5

Pick ATS: Los Angeles

Buffalo Bills at Las Vegas Raiders

Short week for Buffalo after a very impressive 37-34 OT win at the Rams on Monday Night Football to conclude Week 5. That despite playing without a few injured starters, including top WR D.J. Moore. Could be a massive trap spot here then. The Raiders were trounced 45-17 at New England on Sunday for a second straight loss. No. 1 overall rookie QB Fernando Mendoza saw his first real NFL regular-season action in mop-up time but is expected to remain on the bench for now.

Point spread: Bills -5.5

Pick ATS: Las Vegas

Dallas Cowboys at Green Bay Packers

It seems like something memorable happens anytime these two rivals meet, and it’s the Sunday night game. The Cowboys just had no right losing at home in Week 5 on Thursday night as a near double-digit favourite vs. Tampa Bay but did, 24-16. It was the team’s third-largest upset loss (9.5 points) in a start by current QB Dak Prescott. Dallas is now 2-9-1 in its past 12 primetime games. Green Bay played easily its best game of the season Sunday in routing the visiting Bears, 31-7. The Packers had five takeaways, their most in a game since 2016.

Point spread: Packers -1.5

Pick ATS: Green Bay

Washington Commanders at San Francisco 49ers, Monday

The Commanders had a massive clock mistake at the end of overtime Sunday. They should have won it on a very makeable field goal but never even got the kicking team on the field. Clearly QB Jayden Daniels goofed, but head coach Dan Quinn tried to take the heat. His seat is very, very hot right now. The Niners look like perhaps the NFL’s best team at 5-0 after an impressive win in Seattle on Sunday. The last four times the 49ers have started 5-0, they reached at least the NFC title game and got to the Super Bowl in three of those. QB Brock Purdy is your MVP favourite at some books.

Point spread: 49ers -7.5

Pick ATS: San Francisco alt -7