Heading into Week 5 of the NFL regular season, there are six undefeated teams: the New England Patriots, Cincinnati Bengals, Denver Broncos, Green Bay Packers, Atlanta Falcons and the Carolina Panthers. Could one of the unbeatens suffer their first lost of the season?

The undefeated team that faces the biggest challenge this week are the Bengals, who will host the Seattle Seahawks this Sunday. Cincinnati has been winning convincingly, but haven’t faced a stingy defense like the ‘Hawks yet, which will slow the offense down. The Bengals have their own solid defense that could be the difference maker as the Seahawks’ offense has not been particularly good through four weeks of play.

The Falcons are a good pick to remain undefeated against the +7.5 point underdog Redskins at home. While their scedule has afforded them a quick start, their offense has looked unstoppable with Julio Jones gaining more yards than any receiver through four games in the history of the league. Washington has eeked out a few wins against struggling teams, but won’t be able to keep pace with Atlanta on the road.

Before Tony Romo and Dez Bryant were hurt, football fans were salivating at the Patriots vs. Cowboys matchup this week. Without Dallas’ two stars, this game looks like another easy win for the defending Super Bowl champions, who are -8.5 favorites. Despite being on the road, the Cowboys have simply lost too many starters and impact players to injury to stop Tom Brady and Rob Grownkowski from putting up big numbers.

Have a look at your best picks against the spread in Week 5.

NFL Week 5 Schedule