NFL Spreads Week 6: Best Picks Against the Spread

Ricky Rothstein | Updated Oct 10, 2016


And then there was one. Unbeaten that is. The Minnesota Vikings are the only team with a zero still in the loss column entering Week 6 following an impressive 31-13 win over Houston on Sunday. Who needs starting QB Teddy Bridgewater and No. 1 running back Adrian Peterson? That Minnesota defense is clearly Super Bowl-caliber. The Vikings will stay unbeaten this week as they are on the bye, as is Tampa Bay.

Here’s a quick look at all Week 6 matchups with Sports Interaction NFL odds. Games on Sunday unless noted.

Thursday Night Football:Week 6

Denver Broncos at San Diego Chargers, Thursday

Point spread: Broncos -2.5 Total: TBA I will have an in-depth preview of this AFC West matchup on Tuesday. The Chargers often gave the Broncos trouble when Peyton Manning was Denver’s QB. His final regular-season game in the NFL was Week 17 last year when Manning came off the bench in the second half against the visiting Chargers and led a 27-20 win. Pick ATS: Denver

San Francisco 49ers at Buffalo Bills

Point spread: Buffalo -7.5 > Bills -9 Total: 44 One of those tough 1 p.m. ET start times for a West Coast team. But the Niners are on extra rest after losing last Thursday night at home to Arizona, 33-21. It was San Francisco’s fourth straight defeat and quarterback Blaine Gabbert struggled again. Coach Chip Kelly said he would be evaluating that position. It would be an upset, in my opinion, if Colin Kaepernick doesn’t start this one. Buffalo is on a three-game winning streak — all by double digits — after a victory at the Rams on Sunday. Pick ATS: Bills


Philadelphia Eagles at Washington Redskins

Point spread: Eagles -2 > Eagles -2.5 Total: 44.5 Philadelphia is off its first loss, 24-23 in Detroit. Rookie QB Carson Wentz picked a bad time to throw his first NFL interception as it clinched the win for the Lions. Washington pulled a minor upset in Baltimore, 16-10, for its third consecutive victory. It’s the first NFC East Division game of the year for Philly. It was swept last year by the Redskins. The Week 16 home loss gave the division title to Washington, eliminated the Eagles from the playoffs and would prove to be Chip Kelly’s final game as the team’s head coach. Pick ATS: Redskins

Cleveland Browns at Tennessee Titans

Point spread: TBA > Titans -7 Total: TBA Not much positive to say about this game other than the loser will have the upper hand in potentially earning the potential No. 1 overall pick in the 2017 draft. The Titans and Browns finished with the worst records in the NFL last year and held the top two picks in the draft, but both traded them. Tennessee lost at Cleveland in Week 2 last year, 28-14. That was arguably Johnny Manziel‘s best game as a pro for the Browns. Cleveland is the only winless team in the NFL this year and lost a third starting quarterback — rookie Cody Kessler — to injury in Sunday’s loss to New England. He’s questionable for this one. Pick ATS: Titans

Baltimore Ravens at New York Giants

Point spread: New York -3 > Giants -3.5 Total: TBA Baltimore lost a second straight home game Sunday, 16-10 to Washington. Ravens receiver Breshad Perriman appeared to have caught the potential winning 23-yard touchdown pass in the final minute but it was overturned on replay as one of Perriman’s feet was out of bounds. The Ravens played most of the game without receiver Steve Smith, who sprained an ankle late in the first quarter. New York lost a third in a row Sunday night, 23-16 in Green Bay, but Odell Beckham Jr. did catch his first TD of the season. Pick ATS: Giants

Carolina Panthers at New Orleans Saints

Point spread: TBA > Panthers -1 Total: TBA Short week for Carolina as it hosted Tampa Bay on Monday without QB Cam Newton, who was dealing with a concussion. It seems likely he would return for this NFC South game. The Panthers swept the Saints last year but only by a combined eight points. Drew Brees missed the 27-22 loss in Charlotte, the only game he has missed due to injury in his New Orleans career. The Saints were off in Week 5. Pick ATS: Panthers


Jacksonville Jaguars at Chicago Bears

Point spread: Chicago -2  > Bears -1 Total: 47.5 The Jaguars come off their bye. Chicago lost 29-23 at Indianapolis on Sunday playing a third game in a row without starting quarterback Jay Cutler. It certainly wasn’t backup Brian Hoyer‘s fault that the Bears were beaten as he threw for 397 yards and two scores. Even if Cutler is cleared to return this week from his thumb injury, Coach John Fox has hinted that Hoyer will stay the starter. Pick ATS: Jacksonville

Los Angeles Rams at Detroit Lions

Point spread: Detroit -3 Total: 44 Los Angeles saw its three-game winning streak end in a 30-19 home loss to Buffalo on Sunday. The Rams were gashed on the ground as they were without three starting defensive linemen. The Lions ended a three-game skid with a 24-23 home win over Philadelphia. Matt Prater hit the winning 29-yard field goal with 1:28 to go. Detroit visited the Rams in St. Louis in Week 14 last year and the Rams won 21-14 behind 140 yards rushing and two touchdowns from Todd Gurley. Pick ATS: Lions

Pittsburgh Steelers at Miami Dolphins

Point spread: Pittsburgh -7.5 > Steelers -8.5 Total: 48 Pittsburgh improved to 4-1 with a 31-13 win over the Jets. Ben Roethlisberger threw for 380 yards and four touchdowns. He’s in the early conversation for NFL MVP. Miami looked like perhaps the NFL’s worst team on Sunday in a 30-17 home loss to Tennessee. The Dolphins’ run defense is the worst in the league and allowed 235 on the ground to the Titans. QB Ryan Tannehill also really struggled a second straight week. Pick ATS: Miami

Cincinnati Bengals at New England Patriots

Point spread: New England -8 > Patriots -9 Total: 47.5 Think the Pats fans in Foxboro will be amped up for this game? It’s Tom Brady‘s 2016 home debut due to his suspension. Brady made his season debut Sunday and carved up Cleveland for 406 yards and three touchdowns in a blowout win. All three scoring passes went to tight end Martellus Bennett. Cincinnati lost in Dallas 28-14. Andy Dalton threw for 269 yards and two scores but was sacked four times and hit many others. Pick ATS: Patriots


Kansas City Chiefs at Oakland Raiders

Point spread: Oakland -1.5 > Chiefs -1 Total: 47 Kansas City was off in Week 5. Oakland rallied for a wild 34-31 home win over San Diego. Despite the win, the Raiders allowed more than 400 yards for the fourth time in five games. But they are on their first three-game winning streak in five years. The Chiefs swept the Raiders in 2015 but had to rally in the fourth quarter for the 34-20 victory in Oakland. Pick ATS: Raiders

Atlanta Falcons at Seattle Seahawks

Point spread: Seattle -6 Total: 46 Intriguing matchup here between one of the NFL’s best offenses in the Falcons and one of the league’s top defenses in Seattle, which comes off a bye. It’s the second straight week facing a stellar defense for the Falcons as on Sunday they knocked Denver from the ranks of the unbeaten with a 23-16 upset. Matt Ryan threw for 267 yards and a TD, but it was the Falcons’ defense that was the story of the game. Pick ATS: Seahawks

Dallas Cowboys at Green Bay Packers

Point spread: Green Bay -4.5 Total: TBA Dallas won a fourth in a row Sunday, 28-14 over Cincinnati as Ezekiel Elliott ran for 134 yards and two touchdowns. Dak Prescott extended his NFL rookie record to 155 passes without an interception to start his career. The Cowboys again played without No. 1 receiver Dez Bryant, and he’s questionable this week. The Packers beat the visiting Giants 23-16 as Aaron Rodgers threw for two scores. Green Bay has won five in a row against Dallas including playoffs. In 2015, they played Week 14 at Lambeau Field and the Pack rolled 28-7. Rodgers threw for 218 yards and two scores. The Cowboys’ QB that day was the forgettable Matt Cassel and he was terrible. Pick ATS: Packers

Indianapolis Colts at Houston Texans

Point spread: Houston -3 Total: 46 I will preview this Sunday night game later this week. The Colts and Texans have combined to win the past seven AFC South titles and the winner of this one will have an early key tiebreaker. The teams split last year and the Colts didn’t have an injured Andrew Luck for either. Pick ATS: Texans

New York Jets at Arizona Cardinals, Monday

Point spread: Arizona -6.5 > Cardinals -7 Total: TBA Look for an in-depth preview of this matchup later this week. The story line here surrounds Jets second-year head coach Todd Bowles, who prior to being hired by Gang Green in January 2015 was Arizona’s defensive coordinator for two seasons, and the Cardinals still run many of his schemes. Pick ATS: Cardinals