San Francisco 49ers (5-8) at San Diego Chargers (7-6)
— Gotta love those quick turnarounds. After beating Kansas City 31-0 on Sunday afternoon, the Chargers get all of four days to prepare for the San Francisco 49ers, who are fresh off a 40-21 dismantling of Seattle. If they’re looking for a quality game plan, the Chargers might be best served to run the ball early and often as Mike Tolbert, Ryan Mathews and Darren Sproles were outstanding against the Chiefs. Tolbert and Mathews both averaged 4.1 yards on their 16 carries and the trio piled up 207 yards all told.
— Injury update for San Diego: TE Antonio Gates (foot) missed the K.C. game and told reporters the foot isn’t getting any better. He’s been routinely held out of practice, but even with the extra rest the injury isn’t responding. WR Patrick Crayton (wrist) has been out since the MNF win over Denver and won’t return this week. Fellow WR Legedu Naanee (hamstring) will practice this week and see how it feels for Thursday.
–The 49ers gave up only 84 rushing yards to the Seahawks on Sunday and held starting running back Marshawn Lynch to just 29 rushing yards. All told, San Francisco has not given up a 100-yard rushing game in their last 19 outings, which might prevent the Sproles-Tolbert-Mathews trio from achieving the success it had against the Chiefs.
— G Mike Iupati had not missed a snap all season before Sunday’s game but suffered a shoulder stinger while blocking on an extra point. The rookie was replaced by Adam Snyder, and that could be huge this weekend against San Diego. The Niners run to set up the pass. Running without the services of Iupati won’t be easy.
Kansas City Chiefs (8-5) at St. Louis Rams (6-7)
— QB Matt Cassel‘s status for Sunday’s game against St. Louis remained unknown Monday as they Chiefs got back to work after their shutout loss to the Chargers. Cassel did not make the trip to San Diego after undergoing an appendectomy, and the Chiefs were providing no updates on his recuperation. Obviously, they’re going to need Cassel in the lineup based on what Brodie Croyle did against San Diego. He couldn’t muster any points and finished with just 19 passing yards. Yikes.
— LB David Nixon suffered a fractured hand Sunday against New Orleans and will have surgery Tuesday. Nixon won’t practice Wednesday, but he could be available to work later in the week. He is considered questionable for Sunday’s game against Kansas City.